MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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EM127
CAS:1886879-71-5
EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, …
Formula:
C14H18ClN3O3
Purity:
97.61%
Color and Shape:
Liquid
Molecular weight:
311.76
Ref: TM-T60777
| 5mg | 102.00 € | ||
| 10mg | 166.00 € | ||
| 25mg | 347.00 € | ||
| 50mg | 557.00 € | ||
| 100mg | 887.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Lupalbigenin
CAS:76754-24-0
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
Formula:
C25H26O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
406.47
Ref: TM-TN1889
| 1mg | 800.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
RAS GTPase inhibitor 1
CAS:2252242-32-1
RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.
Formula:
C27H28ClF4N5O2
Purity:
99.66%
Color and Shape:
Solid
Molecular weight:
565.99
Ref: TM-T12692
| 1mg | 353.00 € | ||
| 5mg | 845.00 € | ||
| 10mg | 1,154.00 € | ||
| 25mg | 1,688.00 € | ||
| 50mg | 2,217.00 € | ||
| 100mg | 2,888.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Raf inhibitor 1
CAS:1093100-40-3
B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.
Formula:
C26H19ClN8
Purity:
98.05%
Color and Shape:
Solid
Molecular weight:
478.94
Ref: TM-T2074
| 1mg | 38.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 195.00 € | ||
| 50mg | 315.00 € | ||
| 100mg | 459.00 € | ||
| 1mL*10mM (DMSO) | 84.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
ERK-IN-4
CAS:1049738-54-6
ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases …
Formula:
C14H17ClN2O3S
Purity:
98.92% - 99.84%
Color and Shape:
Liquid
Molecular weight:
328.814
Ref: TM-T36675
| 1mg | 47.00 € | ||
| 2mg | 60.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 226.00 € | ||
| 50mg | 334.00 € | ||
| 100mg | 499.00 € | ||
| 1mL*10mM (DMSO) | 104.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
PERK-IN-2
CAS:1337531-83-5
PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).
Formula:
C23H18F3N5O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
437.42
Ref: TM-T12409
| 2mg | 88.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Hydroxycitric acid
CAS:6205-14-7
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of …
Formula:
C6H8O8
Color and Shape:
Solid
Molecular weight:
208.12
Ref: TM-TN1751
| 20mg | 65.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
R1487 Hydrochloride
CAS:449808-64-4
R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.
Formula:
C19H19ClF2N4O3
Purity:
99.42%
Color and Shape:
Solid
Molecular weight:
424.83
Ref: TM-T7162
| 2mg | 71.00 € | ||
| 5mg | 104.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
ERα degrader-2
CAS:2235396-63-9
ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for …
Formula:
C29H27F3N2O2
Purity:
99.71%
Color and Shape:
Solid
Molecular weight:
492.53
Ref: TM-T39727
| 1mg | 247.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
TAK1-IN-3
CAS:494772-87-1
TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.
Formula:
C16H19N3O2S
Purity:
98.88%
Color and Shape:
Solid
Molecular weight:
317.41
Ref: TM-T40577
| 1mg | 50.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Losmapimod
CAS:585543-15-3
Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor …
Formula:
C22H26FN3O2
Purity:
98.56% - 99.05%
Color and Shape:
Solid
Molecular weight:
383.46
Ref: TM-T2277
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 77.00 € | ||
| 25mg | 137.00 € | ||
| 50mg | 222.00 € | ||
| 100mg | 398.00 € | ||
| 500mg | 906.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
CC-401 Hydrochloride
CAS:1438391-30-0
CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) …
Formula:
C22H25ClN6O
Purity:
99.53% - ≥95%
Color and Shape:
Solid
Molecular weight:
424.93
Ref: TM-T5833
| 1mg | 37.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 107.00 € | ||
| 25mg | 209.00 € | ||
| 50mg | 325.00 € | ||
| 100mg | 470.00 € | ||
| 1mL*10mM (DMSO) | 85.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
JNK-IN-8
CAS:1410880-22-6
JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).
Formula:
C29H29N7O2
Purity:
100% - 99.24%
Color and Shape:
Solid
Molecular weight:
507.59
Ref: TM-T2668
| 2mg | 46.00 € | ||
| 5mg | 75.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 204.00 € | ||
| 50mg | 340.00 € | ||
| 100mg | 498.00 € | ||
| 200mg | 707.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
JNK-IN-7
CAS:1408064-71-0
JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).
Formula:
C28H27N7O2
Purity:
99.53% - 99.58%
Color and Shape:
Solid
Molecular weight:
493.56
Ref: TM-T3598
| 1mg | 96.00 € | ||
| 2mg | 155.00 € | ||
| 5mg | 221.00 € | ||
| 10mg | 285.00 € | ||
| 25mg | 514.00 € | ||
| 50mg | 736.00 € | ||
| 100mg | 1,003.00 € | ||
| 1mL*10mM (DMSO) | 244.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BMS582949
CAS:623152-17-0
BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.
Formula:
C22H26N6O2
Purity:
98.43%
Color and Shape:
Solid
Molecular weight:
406.48
Ref: TM-T6789
| 1mg | 86.00 € | ||
| 2mg | 119.00 € | ||
| 5mg | 209.00 € | ||
| 10mg | 296.00 € | ||
| 25mg | 497.00 € | ||
| 50mg | 721.00 € | ||
| 100mg | 1,013.00 € | ||
| 1mL*10mM (DMSO) | 209.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BMS-582949 hydrochloride
CAS:912806-16-7
The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).
Formula:
C22H27ClN6O2
Purity:
97.57% - 98.75%
Color and Shape:
Solid
Molecular weight:
442.95
Ref: TM-T3462
| 1mg | 51.00 € | ||
| 2mg | 73.00 € | ||
| 5mg | 105.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 271.00 € | ||
| 50mg | 435.00 € | ||
| 100mg | 647.00 € | ||
| 500mg | 1,348.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Acumapimod
CAS:836683-15-9
Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).
Formula:
C22H19N5O2
Purity:
≥95%
Color and Shape:
Solid
Molecular weight:
385.42
Ref: TM-T7367
| 1mg | 35.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 157.00 € | ||
| 50mg | 276.00 € | ||
| 100mg | 422.00 € | ||
| 1mL*10mM (DMSO) | 78.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
TAK-632
CAS:1228591-30-7
TAK-632 is a potent pan-Raf inhibitor.
Formula:
C27H18F4N4O3S
Purity:
98% - 98.92%
Color and Shape:
Solid
Molecular weight:
554.52
Ref: TM-T1886
| 5mg | 41.00 € | ||
| 10mg | 49.00 € | ||
| 25mg | 84.00 € | ||
| 50mg | 121.00 € | ||
| 100mg | 208.00 € | ||
| 200mg | 270.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS:1197834-98-2
Pro-neurotropic drug boosts brain acetylcholine synthesis and release, inhibits breakdown.
Formula:
C17H16O5
Purity:
98.68%
Color and Shape:
Solid
Molecular weight:
300.31
Ref: TM-T50064
| 1mg | 86.00 € | ||
| 2mg | 112.00 € | ||
| 5mg | 171.00 € | ||
| 10mg | 255.00 € | ||
| 25mg | 437.00 € | ||
| 50mg | 641.00 € | ||
| 100mg | 912.00 € | ||
| 500mg | 1,798.00 € | ||
| 1mL*10mM (DMSO) | 170.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
A-443654
CAS:552325-16-3
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within …
Formula:
C24H23N5O
Purity:
97.73% - 98.04%
Color and Shape:
Solid
Molecular weight:
397.47
Ref: TM-T14072
| 1mg | 90.00 € | ||
| 5mg | 185.00 € | ||
| 10mg | 301.00 € | ||
| 25mg | 558.00 € | ||
| 50mg | 853.00 € | ||
| 100mg | 1,277.00 € | ||
| 200mg | 1,729.00 € | ||
| 500mg | 2,535.00 € | ||
| 1mL*10mM (DMSO) | 214.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
