MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 897 products of "MAPK"
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Setidegrasib
CAS:KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.Formula:C60H65FN12O7SColor and Shape:SolidMolecular weight:1117.3KRAS inhibitor-24
CAS:KRAS inhibitor-24 (compound 115c), a pyrido-pyridine class KRAS inhibitor, exhibits potent activity against KRas G12V, KRas WT, and KRas G12R, with IC50 values all below 100 nM.Formula:C33H39ClF2N6O3Color and Shape:SolidMolecular weight:641.15KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFormula:C31H30F5N7O2Purity:98%Color and Shape:SolidMolecular weight:627.61MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formula:C28H29F3N6O5SColor and Shape:SolidMolecular weight:618.63MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Color and Shape:SolidMolecular weight:649.4Tagarafdeg
CAS:Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Formula:C45H49F2N11O9SPurity:>99.99% - ＞99.99%Color and Shape:SolidMolecular weight:958KRAS G12D inhibitor 6
CAS:KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.Formula:C32H37ClN8O2Color and Shape:SolidMolecular weight:601.15(S)-BAY-293
CAS:(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.Formula:C25H28N4O2SPurity:98%Color and Shape:SolidMolecular weight:448.58PROTAC K-Ras Degrader-4
CAS:PROTAC K-Ras Degrader-4 is a molecule designed to selectively degrade oncogenic K-Ras mutants, a novel strategy for cancer research.Formula:C50H60N12O6S2Purity:99.30%Color and Shape:SoildMolecular weight:989.22RP03707
CAS:RP03707 is a PROTAC degrader of KRASG12D.Formula:C55H58F3N11O4Color and Shape:SolidMolecular weight:994.12pan-KRAS ligand 1
CAS:Pan-KRAS Ligand 1 serves as a ligand for the target protein of PROTAC (Ligand for Target Protein for PROTAC). This compound facilitates the synthesis of PROTAC Pan-KRAS Degrader 4.Formula:C32H29F2N5O5Color and Shape:SolidMolecular weight:601.6PROTAC SOS1 degrader-1
CAS:PROTAC SOS1 degrader-1: potent, DC50 98.4 nM, inhibits KRAS mutant cancer cells, low-toxic antitumor.Formula:C57H76O4ClFN10SColor and Shape:SoildMolecular weight:1050.54443R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formula:C101H157N27O29S3Purity:98%Color and Shape:SolidMolecular weight:2309.69IPS-06061
IPS-06061 is an orally active molecular glue that forms a ternary complex with CRBN and KRASG12D, capable of degrading KRAS G12D, with a DC50 of less than 500 nM.Formula:C22H26O3Color and Shape:SolidMolecular weight:338.44JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formula:C120H213F3N48O28Purity:98%Color and Shape:SolidMolecular weight:2833.28PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.Formula:C46H55F2N9O9SColor and Shape:SolidMolecular weight:948.05KP-14
KP-14 is a PROTAC specifically designed to target KRAS.Formula:C41H41Cl3N6O8Color and Shape:SolidMolecular weight:852.16TAK1-IN-2
TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM[1].Color and Shape:SolidSAH-SOS1A
CAS:KRas/SOS1 inhibitor; binds KRas pocket, Kd 106-176 nM; blocks nucleotide binding; cytotoxic to KRas-driven cancers; disrupts ERK-MAPK pathway; cell-permeable.Formula:C100H159N27O28Purity:98%Color and Shape:SolidMolecular weight:2187.53KRAS G12C inhibitor 18
CAS:KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Formula:C25H20ClFN4O3SColor and Shape:SolidMolecular weight:510.97
