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Ras

Ras

Ras proteins are small GTPases that act as molecular switches in the MAPK signaling pathway, controlling cell growth, differentiation, and survival. Activated Ras initiates a signaling cascade that includes Raf, MEK, and ERK, leading to various cellular responses. Mutations in Ras genes are common in cancers, making Ras an important focus of cancer research. At CymitQuimica, we offer a range of Ras modulators to support your research in cancer biology, signal transduction, and therapeutic development.

Found 155 products of "Ras"

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  • ESI-08
    Targetmol
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    ESI-08

    CAS:
    <p>ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.</p>
    Formula:C20H23N3OS
    Purity:97.17%
    Color and Shape:Solid
    Molecular weight:353.48

    Ref: TM-T11234

  • KRAS inhibitor-6
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    KRAS inhibitor-6

    CAS:
    <p>KRAS inhibitor-6 is a potent KRAS G12C inhibitor.</p>
    Formula:C27H30ClF2N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:546.01

    Ref: TM-T11773

  • Methylophiopogonanone B
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    Methylophiopogonanone B

    CAS:
    <p>1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.</p>
    Formula:C19H20O5
    Purity:99.24% - 99.83%
    Color and Shape:Solid
    Molecular weight:328.36

    Ref: TM-T5S1261

  • MCP110
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    MCP110

    CAS:
    <p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>
    Formula:C33H36N2O3
    Purity:97.23%
    Color and Shape:Oil
    Molecular weight:508.65

    Ref: TM-T24437

  • BI-2852
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    BI-2852

    CAS:
    <p>BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.</p>
    Formula:C31H28N6O2
    Purity:98.98%
    Color and Shape:Solid
    Molecular weight:516.59

    Ref: TM-T10533

  • PROTAC KRAS G12C degrader-3
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    PROTAC KRAS G12C degrader-3

    CAS:
    <p>PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].</p>
    Formula:C63H75ClN14O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1159.81

    Ref: TM-T79148

  • KRAS G12C inhibitor 58
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    KRAS G12C inhibitor 58

    CAS:
    <p>KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].</p>
    Formula:C51H64ClF4N9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1074.62

    Ref: TM-T79057

  • KRAS G12C inhibitor 5
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    KRAS G12C inhibitor 5

    CAS:
    <p>KRAS G12C inhibitor 5 is a KRas G12C inhibitor.</p>
    Formula:C32H37N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:551.68

    Ref: TM-T11780

  • KRAS G12D modulator-1
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    KRAS G12D modulator-1

    CAS:
    <p>KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is</p>
    Formula:C30H36FN5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:549.64

    Ref: TM-T79072

  • Rac1-IN-3
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    Rac1-IN-3

    CAS:
    <p>Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].</p>
    Formula:C21H23N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:405.45

    Ref: TM-T79869

  • TH-Z827
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    TH-Z827

    CAS:
    <p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>
    Formula:C30H38N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.66

    Ref: TM-T79092

  • KRAS G12C inhibitor 32
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    KRAS G12C inhibitor 32

    CAS:
    <p>KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].</p>
    Formula:C29H30Cl3FN6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:635.94

    Ref: TM-T72335

  • SOS1/KRAS-IN-1
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    SOS1/KRAS-IN-1

    CAS:
    <p>SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].</p>
    Formula:C24H26F3N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:457.49

    Ref: TM-T79162

  • pan-KRAS-IN-2
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    pan-KRAS-IN-2

    CAS:
    <p>Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D</p>
    Formula:C34H34F2N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:584.66

    Ref: TM-T79800

  • pan-KRAS-IN-3
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    pan-KRAS-IN-3

    CAS:
    <p>Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].</p>
    Formula:C33H32F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:587.63

    Ref: TM-T79814

  • KRas G12C inhibitor 1
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    KRas G12C inhibitor 1

    CAS:
    <p>KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.</p>
    Formula:C31H38N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:542.67

    Ref: TM-T11776

  • XRP44X
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    XRP44X

    CAS:
    <p>XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.</p>
    Formula:C21H21ClN4O
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:380.87

    Ref: TM-T20759

  • KRAS G12C inhibitor 59
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    KRAS G12C inhibitor 59

    CAS:
    <p>KRAS G12C Inhibitor 59 is a compound with anticancer properties.</p>
    Formula:C32H39F6N7O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:715.69

    Ref: TM-T79150

  • RBC10
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    RBC10

    CAS:
    <p>RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-</p>
    Formula:C24H25ClN2O2
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:408.92

    Ref: TM-T24706

  • KRAS G12C inhibitor 14
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    KRAS G12C inhibitor 14

    CAS:
    <p>KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].</p>
    Formula:C24H19ClF2N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.88

    Ref: TM-T11768

  • KRAS G12C inhibitor 17
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    KRAS G12C inhibitor 17

    CAS:
    <p>KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.</p>
    Formula:C24H20ClF2N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:471.88

    Ref: TM-T11771

  • CCG-232964
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    CCG-232964

    CAS:
    <p>CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].</p>
    Formula:C15H15ClN2O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.81

    Ref: TM-T82766

  • ML-099
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    ML-099

    CAS:
    <p>ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.</p>
    Formula:C14H13NO2S
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:259.32

    Ref: TM-T22991

  • KRAS G12C inhibitor 13
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    KRAS G12C inhibitor 13

    CAS:
    <p>KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .</p>
    Formula:C40H46F3N7O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:745.83

    Ref: TM-T11767

  • ARS-1323
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    ARS-1323

    CAS:
    <p>ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.</p>
    Formula:C21H17ClF2N4O2
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:430.84

    Ref: TM-T10375

  • pan-KRAS-IN-4
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    pan-KRAS-IN-4

    CAS:
    <p>Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].</p>
    Formula:C36H34F2N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:636.69

    Ref: TM-T79799

  • BDP9066
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    BDP9066

    CAS:
    <p>BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.</p>
    Formula:C20H24N6
    Purity:98.18%
    Color and Shape:Solid
    Molecular weight:348.44

    Ref: TM-T14521

  • Pan-RAS-IN-1
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    Pan-RAS-IN-1

    CAS:
    <p>Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.</p>
    Formula:C36H41Cl2F3N6O2
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:717.65

    Ref: TM-T16432

  • Rho GTPase inhibitor 1
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    Rho GTPase inhibitor 1

    CAS:
    <p>Rho GTPase inhibitor 1 (compound 7) is a potent inhibitor of Rho GTPase. It exhibits high affinity for Cdc42, Rac1, and RhoA, with dissociation constants (KDs) of 151 μM, 352 μM, and 232 μM, respectively. Additionally, Rho GTPase inhibitor 1 reduces cell migration in glioblastoma cell lines.</p>
    Formula:C18H16N2O
    Color and Shape:Solid
    Molecular weight:276.33

    Ref: TM-T207196

  • SOS2 ligand 1
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    SOS2 ligand 1

    CAS:
    <p>SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.</p>
    Formula:C19H21N5O
    Color and Shape:Solid
    Molecular weight:335.403

    Ref: TM-T204872

  • (+)-Perillyl alcohol
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    (+)-Perillyl alcohol

    CAS:
    <p>(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.</p>
    Formula:C10H16O
    Color and Shape:Solid
    Molecular weight:152.23

    Ref: TM-T88792

  • PAT-IN-1
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    PAT-IN-1

    CAS:
    <p>PAT-IN-1, a protein acyl transferases (PAT) inhibitor, competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) [1].</p>
    Formula:C45H68N4O
    Color and Shape:Solid
    Molecular weight:681.05

    Ref: TM-T87110

  • KRAS G12C inhibitor 15
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    KRAS G12C inhibitor 15

    CAS:
    <p>KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .</p>
    Formula:C25H21ClF2N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.91

    Ref: TM-T11769

  • KRAS inhibitor-8
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    KRAS inhibitor-8

    CAS:
    <p>KRAS inhibitor-8 is a potent KRAS G12C inhibitor.</p>
    Formula:C26H24ClF4N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:565.95

    Ref: TM-T11775

  • KRAS G12D inhibitor 26
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    KRAS G12D inhibitor 26

    CAS:
    <p>KRAS G12D inhibitor 26 (Compound 64B) is an inhibitor of KRAS G12D with an IC50 ≤ 100 nM.</p>
    Formula:C35H44ClFN8O2
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:663.23

    Ref: TM-T205666

  • INCB159020
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    INCB159020

    CAS:
    <p>INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.</p>
    Formula:C37H35ClFN7O2
    Color and Shape:Solid
    Molecular weight:664.171

    Ref: TM-T204240

  • pan-KRAS-IN-17
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    pan-KRAS-IN-17

    CAS:
    <p>pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.</p>
    Formula:C34H33F3N5O8P
    Color and Shape:Solid
    Molecular weight:727.623

    Ref: TM-T205570

  • KRAS inhibitor-34
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    KRAS inhibitor-34

    CAS:
    <p>KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.</p>
    Formula:C43H41F3N6O3
    Color and Shape:Solid
    Molecular weight:746.82

    Ref: TM-T200670

  • SOF-436
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    SOF-436

    CAS:
    <p>SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.</p>
    Formula:C15H13F2NO4S2
    Color and Shape:Solid
    Molecular weight:373.395

    Ref: TM-T206673

  • J-104871
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    J-104871

    CAS:
    <p>J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.</p>
    Formula:C38H32N2O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:708.67

    Ref: TM-T24188

  • RGT-018
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    RGT-018

    CAS:
    <p>RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.</p>
    Formula:C27H24F3N7O2
    Color and Shape:Solid
    Molecular weight:535.52

    Ref: TM-T89897

  • KRAS inhibitor-32
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    KRAS inhibitor-32

    CAS:
    <p>KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.</p>
    Formula:C29H35FN10OS2
    Color and Shape:Solid
    Molecular weight:622.78

    Ref: TM-T200688

  • BMS-214662
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    BMS-214662

    CAS:
    <p>BMS-214662 is a selective farnesyl transferase inhibitor with anti-tumor activity, used in research on pancreatic cancer, head and neck cancer, and lung cancer.</p>
    Formula:C25H23N5O2S2
    Purity:99.58% - 99.58%
    Color and Shape:Solid
    Molecular weight:489.61

    Ref: TM-T10567

  • pan-KRAS degrader 1
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    pan-KRAS degrader 1

    CAS:
    <p>Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.</p>
    Formula:C22H26N8OS
    Color and Shape:Solid
    Molecular weight:450.56

    Ref: TM-T200566

  • KRAS inhibitor-37
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    KRAS inhibitor-37

    CAS:
    <p>KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from &lt;2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.</p>
    Formula:C32H33ClFN7O3
    Color and Shape:Solid
    Molecular weight:618.10

    Ref: TM-T201259

  • KRas G12C inhibitor 2
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    KRas G12C inhibitor 2

    CAS:
    <p>KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.</p>
    Formula:C32H37N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:567.68

    Ref: TM-T11777

  • Dorrigocin A
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    Dorrigocin A

    CAS:
    <p>Dorrigocin A, an analog of Migrastatin, inhibits the carboxymethyltransferase involved in Ras processing, reversing the morphology of Ras-transformed NIH/3T3 cells. Dorrigocin A holds potential for research as an anticancer and anti-arthritis agent.</p>
    Formula:C27H41NO8
    Color and Shape:Solid
    Molecular weight:507.616

    Ref: TM-T206492

  • ZCL279
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    ZCL279

    CAS:
    <p>ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (&lt;10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (&lt;10 μM) it significantly inhibits it.</p>
    Formula:C24H18N2O7S2
    Color and Shape:Solid
    Molecular weight:510.539

    Ref: TM-T204446

  • KRAS inhibitor-31
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    KRAS inhibitor-31

    CAS:
    <p>KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.</p>
    Formula:C33H30F3N5O4
    Color and Shape:Solid
    Molecular weight:617.62

    Ref: TM-T200064

  • XMU-MP-9
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    XMU-MP-9

    CAS:
    <p>XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.</p>
    Formula:C19H13ClFN3OS
    Color and Shape:Solid
    Molecular weight:385.84

    Ref: TM-T200189

  • AM-001
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    AM-001

    CAS:
    <p>AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.</p>
    Formula:C24H16FN3OS2
    Color and Shape:Solid
    Molecular weight:445.53

    Ref: TM-T201281

  • KRAS inhibitor-35
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    KRAS inhibitor-35

    CAS:
    <p>KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.</p>
    Formula:C38H32F4N6O3S
    Color and Shape:Solid
    Molecular weight:728.76

    Ref: TM-T200557

  • KRAS inhibitor-41
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    KRAS inhibitor-41

    CAS:
    <p>KRAS inhibitor-41 is a KRAS inhibitor with an IC50 value of less than 0.01 μM for both KRAS G12D and KRAS G12V mutations. It effectively inhibits RAS mutant cell lines GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS inhibitor-41 is applicable for cancer research.</p>
    Formula:C30H37FN10OS
    Color and Shape:Solid
    Molecular weight:604.745

    Ref: TM-T206791

  • Sosimerasib
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    Sosimerasib

    CAS:
    <p>Sosimerasib is an inhibitor of the kirsten rat sarcoma viral oncogene homolog (KRAS) and exhibits antitumor activity.</p>
    Formula:C36H39ClFN7O4
    Color and Shape:Solid
    Molecular weight:688.191

    Ref: TM-T206171

  • KRAS G12D inhibitor 28
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    KRAS G12D inhibitor 28

    CAS:
    <p>KRAS G12D inhibitor 28 (Compound 1) is an inhibitor of KRAS G12D and can be utilized in cancer research.</p>
    Formula:C35H32Cl2FN5O
    Color and Shape:Solid
    Molecular weight:628.57

    Ref: TM-T207473