ERK
ERK is a key protein in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which is involved in transmitting signals from cell surface receptors to the DNA in the cell nucleus. ERK plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and survival. Dysregulation of ERK signaling is associated with the development of cancer and other diseases, making it an important target for therapeutic intervention. At CymitQuimica, we offer a selection of high-quality ERK inhibitors and modulators to support your research in cell signaling, oncology, and therapeutic development.
Found 217 products of "ERK"
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MEK/PI3K-IN-1
CAS:MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.Formula:C36H37F5IN9O6Color and Shape:SolidMolecular weight:913.63Anti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Formula:C27H29NO8Purity:99.98%Color and Shape:SoildMolecular weight:495.52VSLRGDTRG
CAS:VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.Formula:C38H69N15O14Color and Shape:SolidMolecular weight:960.047PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purity:99.66%Color and Shape:SolidMolecular weight:476.23Ref: TM-T21980
1mg64.00€5mg138.00€1mL*10mM (DMSO)160.00€10mg188.00€25mg330.00€50mg472.00€100mg655.00€500mg1,293.00€Astragaloside
CAS:Astragaloside, one of the main active ingredients in Astragalus membranaceus.Formula:C28H32O17Purity:99.9%Color and Shape:Odour SolidMolecular weight:640.54KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.Formula:C29H29ClF3N5O3Color and Shape:SolidMolecular weight:588.02MEK/PI3K-IN-2
CAS:MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.Formula:C38H41F5IN9O7Color and Shape:SolidMolecular weight:957.68BTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Formula:C50H57F4N9O5Color and Shape:SolidMolecular weight:940.044-P-PDOT
CAS:4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.Formula:C19H21NOPurity:99.91%Color and Shape:SolidMolecular weight:279.38PROTAC HPK1 Degrader-5
PROTACHPK1 Degrader-5 is a potent, orally active HPK1 PROTAC degrader with a DC50 of 5.0 nM and a Dmax of at least 99%. It significantly inhibits HPK1 by degrading it, reducing SLP76 phosphorylation, and enhancing ERK pathway activation, which in turn stimulates the release of IL-2 and IFN-γ. This compound effectively counteracts immune suppression induced by PGE2, NECA, or TGF-β. Alone, PROTACHPK1 Degrader-5 is capable of suppressing tumor growth in MC38 syngeneic mouse models. It is used in research for immunotherapy applications in cancers such as colorectal cancer.Color and Shape:Odour SolidPamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Formula:C23H16NaO6Purity:99.73%Color and Shape:Yellow PowderMolecular weight:411.36ERK2 Protein, Mouse, Recombinant (His & GST)
ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Color and Shape:Lyophilized PowderMolecular weight:69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His & hFc)
EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.Color and Shape:Lyophilized PowderMolecular weight:86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Color and Shape:Lyophilized PowderMolecular weight:84.6 kDa (predicted); 96.6 kDa (reducing conditions)EPHB2 Protein, Cynomolgus, Recombinant (His)
EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.Color and Shape:Lyophilized PowderMolecular weight:59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.Color and Shape:Lyophilized PowderMolecular weight:75.2 kDa (predicted); 65 kDa (reducing conditions)GPR34 receptor antagonist 3
Compound 5e, a GPR34 receptor antagonist, exhibits selective inhibition of lysophosphatidylserine-induced ERK1/2 phosphorylation in a dose-dependent manner,Color and Shape:Odour SolidERK2 Protein, Human, Recombinant (GST)
ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Color and Shape:Lyophilized PowderMolecular weight:67 kDa (predicted); 67 kDa (reducing conditions)SBI-810 hydrochloride
CAS:SBI-810 hydrochloride is a β-arrestin-2 (βarr2)-biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects.Formula:C27H35ClN4O2Purity:99.42%Color and Shape:SolidMolecular weight:483.05EphB2 Protein, Mouse, Recombinant (His)
EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:59.3 kDa (predicted); 65 kDa (reducing conditions)ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFormula:C29H27F3N2O2Purity:99.71%Color and Shape:SolidMolecular weight:492.53EM127
CAS:EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Formula:C14H18ClN3O3Purity:97.55%Color and Shape:SolidMolecular weight:311.76PERK-IN-2
CAS:PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Formula:C23H18F3N5OPurity:98%Color and Shape:SolidMolecular weight:437.42EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)TRPM4 inhibitor 8
CAS:TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Formula:C11H17BrN2Purity:99.84%Color and Shape:SolidMolecular weight:257.17Ref: TM-T9776
5mg44.00€1mL*10mM (DMSO)48.00€10mg62.00€25mg90.00€50mg170.00€100mg268.00€200mg403.00€500mg660.00€(E/Z)-BIX 02189
CAS:(E/Z)-BIX 02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.Formula:C27H28N4O2Purity:98% - 99.89%Color and Shape:SolidMolecular weight:440.54Ref: TM-T2416
1mg38.00€5mg82.00€1mL*10mM (DMSO)92.00€10mg116.00€25mg210.00€50mg358.00€100mg550.00€200mg780.00€SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurity:99.56%Color and Shape:SolidMolecular weight:336.15Ref: TM-T8719
1mg43.00€5mg87.00€1mL*10mM (DMSO)94.00€10mg133.00€25mg227.00€50mg344.00€100mg429.00€200mg597.00€Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purity:99.97%Color and Shape:SolidMolecular weight:335.33N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formula:C11H15NOPurity:99.46% - 99.84%Color and Shape:SolidMolecular weight:177.24Corynoxeine
CAS:Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.Formula:C22H26N2O4Purity:98.61% - 99.94%Color and Shape:SolidMolecular weight:382.45Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purity:99.66% - 99.74%Color and Shape:SolidMolecular weight:696.82Ref: TM-T5S1982
1mg35.00€5mg77.00€10mg106.00€1mL*10mM (DMSO)107.00€25mg170.00€50mg253.00€100mg375.00€500mg892.00€Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purity:99.36%Color and Shape:SolidMolecular weight:451.6Pachymic acid
CAS:Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.Formula:C33H52O5Purity:99.39% - >99.99%Color and Shape:White PowderMolecular weight:528.76VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formula:C24H20Cl2FN5O2Purity:98.92% - ≥98%Color and Shape:SolidMolecular weight:500.35Theliatinib
CAS:Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formula:C25H26N6O2Purity:99.67%Color and Shape:SolidMolecular weight:442.51DCLK1-IN-1
CAS:DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.
Formula:C26H28F3N7O2Purity:98.55% - 99.28%Color and Shape:SolidMolecular weight:527.54Ref: TM-T8418
2mg139.00€5mg207.00€1mL*10mM (DMSO)265.00€10mg354.00€25mg587.00€50mg835.00€100mg1,149.00€200mg1,549.00€SCH772984
CAS:SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.
Formula:C33H33N9O2Purity:97.565% - 98.75%Color and Shape:SolidMolecular weight:587.67Ref: TM-T6066
1mg52.00€2mg77.00€5mg99.00€10mg148.00€25mg291.00€50mg437.00€100mg642.00€200mg914.00€500mg1,359.00€AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purity:98.72%Color and Shape:SolidMolecular weight:461.23ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Formula:C25H29N7O2Purity:97.70%Color and Shape:SolidMolecular weight:459.54Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Formula:C21H22Cl2N4O2Purity:99.31% - 99.95%Color and Shape:SolidMolecular weight:433.33GPR34 receptor antagonist 2
CAS:GPR34 receptor antagonist 2 (Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-) is an anti-inflammatory agent.Formula:C31H26ClNO4Purity:97.26%Color and Shape:SolidMolecular weight:512Ref: TM-T8848
1mg110.00€5mg259.00€1mL*10mM (DMSO)288.00€10mg425.00€25mg700.00€50mg982.00€100mg1,314.00€500mg2,637.00€Peramivir Trihydrate
CAS:Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are
Formula:C15H28N4O4·3H2OPurity:99.52% - ≥95%Color and Shape:SolidMolecular weight:382.45Ref: TM-T2522
2mg47.00€5mg70.00€10mg103.00€25mg188.00€50mg311.00€100mg439.00€200mg635.00€500mg938.00€magnolin
CAS:Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
Formula:C23H28O7Purity:98% - 99.77%Color and Shape:SolidMolecular weight:416.46Temuterkib
CAS:LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.
Formula:C22H27N7O2SPurity:99.57% - >99.99%Color and Shape:SolidMolecular weight:453.56UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Formula:C22H29FN6Purity:98.91% - 99.67%Color and Shape:SolidMolecular weight:396.5Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purity:99.85% - 99.90%Color and Shape:SolidMolecular weight:476.73Triptonide
CAS:Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.Formula:C20H22O6Purity:99.11% - 99.64%Color and Shape:White Crystalline PowderMolecular weight:358.39Ref: TM-T5S1058
1mg52.00€2mg74.00€5mg108.00€1mL*10mM (DMSO)133.00€10mg158.00€25mg268.00€50mg409.00€100mg595.00€200mg833.00€TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purity:99.17% - 99.53%Color and Shape:White Solid PowderMolecular weight:166.22DEL-22379
CAS:DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.Formula:C26H28N4O3Purity:99.3% - 99.53%Color and Shape:SolidMolecular weight:444.53
