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Raf

Raf

Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.

Found 83 products of "Raf"

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  • AZ 628
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    AZ 628

    CAS:
    <p>AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.</p>
    Formula:C27H25N5O2
    Purity:99.50%
    Color and Shape:Solid
    Molecular weight:451.52

    Ref: TM-T6318

  • Raf inhibitor 1 dihydrochloride
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    Raf inhibitor 1 dihydrochloride

    CAS:
    <p>Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.</p>
    Formula:C26H19ClN8HCl
    Purity:98.19% - 99.54%
    Color and Shape:Solid
    Molecular weight:551.86

    Ref: TM-T4167

  • Raf inhibitor 1
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    Raf inhibitor 1

    CAS:
    <p>B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.</p>
    Formula:C26H19ClN8
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:478.94

    Ref: TM-T2074

  • TBAP-001
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    TBAP-001

    CAS:
    <p>TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.</p>
    Formula:C27H23F2N7O3
    Purity:99.58%
    Color and Shape:Solid
    Molecular weight:531.51

    Ref: TM-T9693

  • PLX7904
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    PLX7904

    CAS:
    <p>PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.</p>
    Formula:C24H22F2N6O3S
    Purity:99.51% - 99.66%
    Color and Shape:Solid
    Molecular weight:512.53

    Ref: TM-T6949

  • B-Raf IN 13
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    B-Raf IN 13

    CAS:
    <p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>
    Formula:C19H19ClFN3O4S
    Purity:99.41% - >99.99%
    Color and Shape:Soild
    Molecular weight:439.89

    Ref: TM-T67862

  • GDC-0879
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    GDC-0879

    CAS:
    <p>GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.</p>
    Formula:C19H18N4O2
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:334.37

    Ref: TM-T6320

  • MCP110
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    MCP110

    CAS:
    <p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>
    Formula:C33H36N2O3
    Purity:97.23%
    Color and Shape:Oil
    Molecular weight:508.65

    Ref: TM-T24437

  • BRAF inhibitor
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    BRAF inhibitor

    CAS:
    <p>BRAF inhibitor is an inhibitor of B-Raf.</p>
    Formula:C22H18F2N4O3S
    Purity:98.2% - 98.41%
    Color and Shape:Solid
    Molecular weight:456.47

    Ref: TM-T10599

  • SOS1-IN-15
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    SOS1-IN-15

    CAS:
    <p>SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.</p>
    Formula:C28H27F3N6O2
    Purity:98.32%
    Color and Shape:Solid
    Molecular weight:536.548

    Ref: TM-T73164

  • GSK2008607
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    GSK2008607

    CAS:
    <p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>
    Formula:C31H28F3N7O3S2
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:667.72

    Ref: TM-T27454

  • Raf inhibitor 3
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    Raf inhibitor 3

    CAS:
    <p>Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].</p>
    Formula:C18H19FN8O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.46

    Ref: TM-T79813

  • Uplarafenib
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    Uplarafenib

    CAS:
    <p>Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.</p>
    Formula:C22H21F3N4O4S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:494.49

    Ref: TM-T63333

  • Lifirafenib
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    Lifirafenib

    CAS:
    <p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>
    Formula:C25H17F3N4O3
    Purity:98% - 98.25%
    Color and Shape:Solid
    Molecular weight:478.42

    Ref: TM-T22272

  • B-Raf IN 15
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    B-Raf IN 15

    CAS:
    <p>B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.</p>
    Formula:C19H15N3OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:333.41

    Ref: TM-T78183

  • B-Raf IN 16
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    B-Raf IN 16

    CAS:
    <p>B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.</p>
    Formula:C20H19N5O3S
    Purity:99.31% - 99.78%
    Color and Shape:Solid
    Molecular weight:409.46

    Ref: TM-T79830

  • Exarafenib
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    Exarafenib

    CAS:
    <p>Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer research.</p>
    Formula:C26H34F3N5O3
    Purity:98.36% - 99.84%
    Color and Shape:Solid
    Molecular weight:521.58

    Ref: TM-T63644

  • HG6-64-1
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    HG6-64-1

    CAS:
    <p>HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.</p>
    Formula:C32H34F3N5O2
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:577.64

    Ref: TM-T15480

  • pan-Raf/RTK inhibitor 1
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    pan-Raf/RTK inhibitor 1

    CAS:
    <p>Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). It exhibits antiproliferative activity against various cancer cell lines and can be utilized in cancer research.</p>
    Formula:C29H28F3N7O3
    Color and Shape:Solid
    Molecular weight:579.573

    Ref: TM-T204155

  • Brimarafenib
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    Brimarafenib

    CAS:
    <p>Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.</p>
    Formula:C24H17F3N4O4
    Purity:98.32%
    Color and Shape:Solid
    Molecular weight:482.41

    Ref: TM-T89116