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CFTR

CFTR

CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.

Found 67 products for "CFTR".

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  • GLPG1837
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    GLPG1837

    CAS:
    GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
    Formula:C16H20N4O3S
    Purity:99.64% - 99.91%
    Color and Shape:Solid
    Molecular weight:348.42

    Ref: TM-T7083

  • Glibenclamide potassium
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    Glibenclamide potassium

    CAS:
    Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.
    Formula:C23H27ClKN3O5S
    Color and Shape:Solid
    Molecular weight:532.09

    Ref: TM-T72272

  • KM11060
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    KM11060

    CAS:
    KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma
    Formula:C19H17Cl2N3O2S
    Purity:99.08%
    Color and Shape:Solid
    Molecular weight:422.328

    Ref: TM-T3135

  • Icenticaftor
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    Icenticaftor

    CAS:
    Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.
    Formula:C12H13F6N3O3
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:361.2403

    Ref: TM-T9499

  • Ataluren
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    Ataluren

    CAS:
    Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.
    Formula:C15H9FN2O3
    Purity:99.16% - 99.84%
    Color and Shape:Solid
    Molecular weight:284.24

    Ref: TM-T1805

  • Lumacaftor
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    Lumacaftor

    CAS:
    Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
    Formula:C24H18F2N2O5
    Purity:99.48% - 99.68%
    Color and Shape:Solid
    Molecular weight:452.4069

    Ref: TM-T2595

  • IOWH-032
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    IOWH-032

    CAS:
    IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
    Formula:C22H15Br2N3O4
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:545.18

    Ref: TM-T2486

  • CFTR(inh)-172
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    CFTR(inh)-172

    CAS:
    CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.
    Formula:C18H10F3NO3S2
    Purity:98% - 99.72%
    Color and Shape:Solid
    Molecular weight:409.402

    Ref: TM-T2355

  • Tezacaftor
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    Tezacaftor

    CAS:
    Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
    Formula:C26H27F3N2O6
    Purity:98.84% - >99.99%
    Color and Shape:Solid
    Molecular weight:520.4976

    Ref: TM-T2263

  • CFTR corrector 2
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    CFTR corrector 2

    CAS:
    CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.
    Formula:C27H23FN4O4
    Purity:99.66%
    Color and Shape:White Solid
    Molecular weight:486.4943

    Ref: TM-T5312

  • GlyH-101
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    GlyH-101

    CAS:
    GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
    Formula:C19H15Br2N3O3
    Purity:98.71% - 98.78%
    Color and Shape:White Solid
    Molecular weight:493.149

    Ref: TM-T2451

  • SRI-41315
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    SRI-41315

    CAS:
    SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.
    Formula:C22H19N3O2
    Purity:99.93%
    Color and Shape:White Solid
    Molecular weight:357.41

    Ref: TM-T61306

  • Steviol
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    Steviol

    CAS:
    1.
    Formula:C20H30O3
    Purity:98% - 99.92%
    Color and Shape:White Solid
    Molecular weight:318.4504

    Ref: TM-T2S1837

  • AF-2785
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    AF-2785

    CAS:
    In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.
    Formula:C17H12Cl2N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:347.2

    Ref: TM-T23648

  • CFTR corrector 9
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    CFTR corrector 9

    CAS:
    CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.
    Formula:C16H14N2O4
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:298.2934

    Ref: TM-T60653

  • Posenacaftor
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    Posenacaftor

    CAS:
    Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.
    Formula:C27H27NO5
    Color and Shape:Solid
    Molecular weight:445.51

    Ref: TM-T62630

  • Posenacaftor sodium
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    Posenacaftor sodium

    CAS:
    Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.
    Formula:C27H27NNaO5
    Color and Shape:Solid
    Molecular weight:468.505

    Ref: TM-T36519

  • Corrector C4
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    Corrector C4

    CAS:
    Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and
    Formula:C21H17ClN4O2S2
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:456.97

    Ref: TM-T31014

  • Galicaftor
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    Galicaftor

    CAS:
    ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).
    Formula:C28H21F4NO7
    Purity:98.84%
    Color and Shape:Yellow Solid
    Molecular weight:559.4625

    Ref: TM-T22252

  • (R)-Posenacaftor sodium
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    (R)-Posenacaftor sodium

    CAS:
    (R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.
    Formula:C27H27NNaO5
    Color and Shape:Solid
    Molecular weight:468.505

    Ref: TM-T35925