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Potassium Channel

Potassium Channel

Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.

Found 280 products of "Potassium Channel"

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  • ZM 226600
    Targetmol
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    ZM 226600

    CAS:
    ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.
    Formula:C16H14F3NO4S
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:373.35

    Ref: TM-T23563

  • PD-118057
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    PD-118057

    CAS:
    <p>PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.</p>
    Formula:C21H17Cl2NO2
    Purity:99.16% - 99.97%
    Color and Shape:Solid
    Molecular weight:386.27

    Ref: TM-T16444

  • UK 66914
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    UK 66914

    CAS:
    <p>UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.</p>
    Formula:C18H24N4O3S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:376.47

    Ref: TM-T29050

  • DMP-543
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    DMP-543

    CAS:
    <p>DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.</p>
    Formula:C26H18F2N2O
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:412.43

    Ref: TM-T15143

  • (+)-KCC2 blocker 1
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    (+)-KCC2 blocker 1

    CAS:
    (+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).
    Formula:C22H25NO5S
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:415.5

    Ref: TM-T12504

  • KT-362 fumarate
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    KT-362 fumarate

    CAS:
    <p>KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.</p>
    Formula:C26H32N2O7S
    Purity:99.75% - 99.98%
    Color and Shape:Solid
    Molecular weight:516.61

    Ref: TM-T27753

  • TWIK-1/TREK-1-IN-3
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    TWIK-1/TREK-1-IN-3

    CAS:
    <p>TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.</p>
    Formula:C19H27F3N2O2
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:372.43

    Ref: TM-T78870

  • IKs124
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    IKs124

    CAS:
    <p>IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.</p>
    Formula:C18H26N2O3S
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:350.48

    Ref: TM-T27593

  • TASK-1-IN-1
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    TASK-1-IN-1

    CAS:
    <p>TASK-1-IN-1: Potent, selective TASK-1 blocker (IC50: 148 nM), weaker on TASK-3 (IC50: 1750 nM), anticancer properties.</p>
    Formula:C22H20N2O2
    Purity:99.57%
    Color and Shape:Soild
    Molecular weight:344.41

    Ref: TM-T72064

  • Glibornuride
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    Glibornuride

    CAS:
    Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).
    Formula:C18H26N2O4S
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:366.48

    Ref: TM-T15385

  • Sigma-1 receptor antagonist 3
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    Sigma-1 receptor antagonist 3

    CAS:
    <p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>
    Formula:C19H23ClFN3O
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:363.86

    Ref: TM-T12912

  • P-1075
    Targetmol
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    P-1075

    CAS:
    P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.
    Formula:C12H17N5
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:231.3

    Ref: TM-T16420

  • CLP257
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    CLP257

    CAS:
    <p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>
    Formula:C14H14FN3O2S
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:307.34

    Ref: TM-T14984

  • 11-deoxy-PGF2a
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    11-deoxy-PGF2a

    CAS:
    <p>11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contraction</p>
    Formula:C20H34O4
    Color and Shape:Solid
    Molecular weight:338.48

    Ref: TM-T26376

  • Linaprazan
    Targetmol
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    Linaprazan

    CAS:
    <p>Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.</p>
    Formula:C21H26N4O2
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:366.46

    Ref: TM-T10435

  • MCHR1 antagonist 2
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    MCHR1 antagonist 2

    CAS:
    MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.
    Formula:C23H21FN2O5
    Purity:98.29%
    Color and Shape:Solid
    Molecular weight:424.42

    Ref: TM-T11966

  • DPO-1
    Targetmol
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    DPO-1

    CAS:
    <p>DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。</p>
    Formula:C22H29OP
    Purity:99.78%
    Color and Shape:Solid
    Molecular weight:340.44

    Ref: TM-T22745

  • VU0463271
    Targetmol
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    VU0463271

    CAS:
    <p>VU0463271: KCC2 antagonist, IC50 61 nM, &gt;100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>
    Formula:C19H18N4OS2
    Purity:97.84% - 99.55%
    Color and Shape:Solid
    Molecular weight:382.5

    Ref: TM-T17243

  • Clobutinol hydrochloride
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    Clobutinol hydrochloride

    CAS:
    <p>Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].</p>
    Formula:C14H23Cl2NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:292.25

    Ref: TM-T78523

  • C 101248
    Targetmol
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    C 101248

    CAS:
    C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.
    Formula:C15H12N6O
    Purity:99.14% - 99.31%
    Color and Shape:Solid
    Molecular weight:292.3

    Ref: TM-T83962

  • Kv3 modulator 1
    Targetmol
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    Kv3 modulator 1

    CAS:
    <p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>
    Formula:C20H20N4O4
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:380.4

    Ref: TM-T11787

  • Kv7.2/Kv7.3 agonist 1
    Targetmol
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    Kv7.2/Kv7.3 agonist 1

    CAS:
    <p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>
    Formula:C14H14FN3O2
    Color and Shape:Solid
    Molecular weight:275.28

    Ref: TM-T201063

  • Kv7.2/Kv7.3 activator-1
    Targetmol
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    Kv7.2/Kv7.3 activator-1

    CAS:
    <p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>
    Formula:C19H22F2N4O
    Color and Shape:Solid
    Molecular weight:360.40

    Ref: TM-T89880

  • Kv3 modulator 5
    Targetmol
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    Kv3 modulator 5

    CAS:
    Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].
    Formula:C20H20N4O4
    Color and Shape:Solid
    Molecular weight:380.4

    Ref: TM-T86792

  • KCC2 Modulator-2
    Targetmol
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    KCC2 Modulator-2

    CAS:
    <p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>
    Formula:C35H45N5O3
    Color and Shape:Solid
    Molecular weight:583.76

    Ref: TM-T201666

  • cis-KV1.3-IN-1
    Targetmol
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    cis-KV1.3-IN-1

    CAS:
    cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.
    Formula:C23H30N2O4S
    Color and Shape:Solid
    Molecular weight:430.56

    Ref: TM-T201783

  • KV1.3-IN-2
    Targetmol
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    KV1.3-IN-2

    CAS:
    <p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>
    Formula:C16H23ClN2O4
    Color and Shape:Solid
    Molecular weight:342.818

    Ref: TM-T205655

  • Opakalim
    Targetmol
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    Opakalim

    CAS:
    <p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>
    Formula:C18H22F2N4O
    Color and Shape:Solid
    Molecular weight:348.39

    Ref: TM-T206117

  • Kv7.2/Kv7.3 modulator-1
    Targetmol
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    Kv7.2/Kv7.3 modulator-1

    CAS:
    Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.
    Formula:C20H21F4N3O3
    Color and Shape:Solid
    Molecular weight:427.393

    Ref: TM-T206950

  • Indapamide
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    Indapamide

    CAS:
    <p>Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.</p>
    Formula:C16H16ClN3O3S
    Purity:98.97% - 99.83%
    Color and Shape:Solid
    Molecular weight:365.83

    Ref: TM-T1498

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