Potassium Channel
Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.
Found 304 products of "Potassium Channel"
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Phe-Met-Arg-Phe, amide
CAS:Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Formula:C29H42N8O4SPurity:98%Color and Shape:SolidMolecular weight:598.76Potassium Channel Targeted Library
A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;Color and Shape:Odour SolidRef: TM-L7300
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireGuanfu base A
CAS:Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.Formula:C24H31NO6Purity:99.71% - 99.85%Color and Shape:SolidMolecular weight:429.5BeKm-1
CAS:Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Formula:C174H261N51O52S6Purity:98%Color and Shape:SolidMolecular weight:4091.65Guangxitoxin 1E
CAS:Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.Formula:C178H248N44O45S7Purity:98%Color and Shape:SolidMolecular weight:3948.61Slotoxin
Slotoxin, a peptide extracted from the venom of the Centruroides noxius Hoffmann scorpion, inhibits high-conductance calcium-activated potassium channels with aFormula:C177H275N47O50S7Purity:98%Color and Shape:SolidMolecular weight:4085.82Lei-Dab7
CAS:Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formula:C141H236N46O39S6Purity:98%Color and Shape:SolidMolecular weight:3392.06GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodiumFormula:C176H261N47O45S7Purity:98%Color and Shape:SolidMolecular weight:3979.7Jingzhaotoxin-XII TFA
Jingzhaotoxin-XII (JzTx-XII) TFA is a specific inhibitor of the Kv4.1 channel, exhibiting an IC50 of 0.363 μM. It interacts with the channel by altering gating behavior.Color and Shape:Odour SolidκM-Conotoxin RIIIJ
κM-Conotoxin RIIIJ (κM-RIIIJ) selectively inhibits Kv1.2 channels, exhibiting an IC50 value of 33 nM [1].Formula:C117H184N32O36S6Purity:98%Color and Shape:SolidMolecular weight:2807.3KTX-Sp2
KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3Formula:C155H244N58O49S7Purity:98%Color and Shape:SolidMolecular weight:3928.41Tertiapin-Q acetate
Tertiapin-Q acetate is a bee toxin derivative that inhibits BK-type K(+) channels in a concentration-dependent manner.Formula:C108H179N35O26S4Purity:96.44%Color and Shape:SolidMolecular weight:2512.06Iberiotoxin TFA
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet itFormula:C179H274N50O55S7·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:4230.85 (free base)Dendrotoxin-I
CAS:Dendrotoxin-I, a neurotoxin from Dendroaspis snake venom, potently blocks K⁺ channels, specifically targeting voltage-gated potassium channel subunits KV1.1 andFormula:C312H491N99O83S6Purity:98%Color and Shape:SolidMolecular weight:7149.24Heteropodatoxin-1
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9Formula:C168H238N46O51S6Purity:98%Color and Shape:SolidMolecular weight:3910.35ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Formula:C166H268N54O48S7Purity:98%Color and Shape:SolidMolecular weight:4012.7Tertiapin-RQ
Tertiapin-RQ, an inward rectifier potassium (K+) channel-blocking peptide, exhibits antidepressant effects [1].Formula:C106H175N37O25S4Purity:98%Color and Shape:SolidMolecular weight:2496.02Maurotoxin
CAS:Maurotoxin, a 34-residue peptide featuring four disulfide bridges, is extracted from the chactoid scorpion (Scorpio maurus) and known to impede Shaker potassiumFormula:C145H232N46O46S8Purity:98%Color and Shape:SolidMolecular weight:3612.19Phrixotoxin 2
CAS:Phrixotoxin 2 selectively blocks the KV 4.2 and KV 4.3 channels, demonstrating high specificity in its interaction with these voltage-gated ion channels [1].Formula:C169H259N49O43S8Purity:98%Color and Shape:SolidMolecular weight:3921.69Vm24-toxin
CAS:Vm24-toxin, a peptide toxin isolated from the Mexican scorpion Vaejovis mexicanus smithi, serves as an inhibitor of the Kv1.3 potassium channel [1].Formula:C157H253N51O45S9Purity:98%Color and Shape:SolidMolecular weight:3863.59Charybdotoxin
CAS:Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formula:C176H277N57O55S7Purity:98%Color and Shape:SolidMolecular weight:4295.95Hongotoxin-1
Hongotoxin-1, a chemical compound isolated from the venom of Centruroides limbatus, functions as a potassium channel inhibitor.Formula:C181H299N53O49S7Purity:98%Color and Shape:SolidMolecular weight:4226.13Tamapin
Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated KFormula:C146H238N44O41S6Purity:98%Color and Shape:SolidMolecular weight:3458.11BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Formula:C22H23F7N2O3Color and Shape:SolidMolecular weight:496.418Stromatoxin 1
CAS:Stromatoxin 1, a peptide isolated from tarantulas, acts as an inhibitor of various potassium channels, including K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3.Formula:C156H237N49O48S7Purity:98%Color and Shape:SolidMolecular weight:3791.31Apamin
CAS:Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.Formula:C79H131N31O24S4Purity:98%Color and Shape:SolidMolecular weight:2027.34Aam-KTX
Aam-KTX, a toxic peptide sourced from Mesobuthus eupeus scorpion venom, acts as a selective K_v channel inhibitor, exhibiting IC_50 values of 1.1 nM for K_v1.3Formula:C174H288N58O48S7Purity:98%Color and Shape:SolidMolecular weight:4184.96Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Formula:C169H278N54O48S8Purity:98%Color and Shape:SolidMolecular weight:4090.87HG1 Toxin
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.Formula:C337H503N103O97S6Molecular weight:7736.59176ShK toxin
CAS:ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel).Formula:C169H274N54O48S7Purity:98%Color and Shape:SolidMolecular weight:4054.8RU-TRAAK-2
CAS:RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.
Formula:C19H17N3OSPurity:99.81%Color and Shape:SolidMolecular weight:335.42BmP02
BmP02, a compound isolated from Chinese scorpion (Buthus martensi Karsch) venom, acts as a selective Kv1.3 channel blocker and a highly-selective Kv4.2Formula:C115H182N36O41S7Purity:98%Color and Shape:SolidMolecular weight:2949.35Ssm spooky toxin
Ssm Spooky Toxin, derived from Scolopendra mutilans, exhibits potent lethality affecting both hematological and respiratory systems primarily through theFormula:C270H413N69O79S4Purity:98%Color and Shape:SolidMolecular weight:6017.84Foslevcromakalim
CAS:Foslevcromakalim (QLS-101) is an KATP opener, converted to its active form by alkaline phosphatase in vivo, reduces intraocular pressure in normotensive mice.Formula:C16H19N2O6PPurity:99.73%Color and Shape:SolidMolecular weight:366.31Hemitoxin
Hemitoxin, a scorpion-venom peptide, functions as a K+ channel blocker and selectively inhibits rat Kv1.1, Kv1.2, and Kv1.3 channels expressed in XenopusFormula:C159H259N49O49S8Purity:98%Color and Shape:SolidMolecular weight:3897.58Spinoxin
CAS:Spinoxin, a 34-residue peptide neurotoxin extracted from the venom of Heterometrus spinifer, is characterized by four disulfide bridges.Formula:C147H236N48O46S9Purity:98%Color and Shape:SolidMolecular weight:3700.33Tamapin TFA
Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated KFormula:C146H238N44O41S6·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:3458.11 (free base)Aa1 toxin
Aa1 toxin, sourced from Androctonus australis Garzoni venom, is a neurotoxic peptide that specifically blocks potassium channels and has applications inFormula:C156H260N54O49S6Purity:98%Color and Shape:SolidMolecular weight:3868.46Cromakalim
CAS:Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.Formula:C16H18N2O3Purity:99.39%Color and Shape:SolidMolecular weight:286.33Neosolaniol
CAS:Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.Formula:C19H26O8Purity:98%Color and Shape:SolidMolecular weight:382.4Endoxifen Z-isomer hydrochloride
CAS:Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.Formula:C25H28ClNO2Color and Shape:SolidMolecular weight:409.95KCNQ1 activator-1
CAS:N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.Formula:C22H23N3O4S2Purity:99.71%Color and Shape:SolidMolecular weight:457.57Ref: TM-T9778
1mg40.00€5mg89.00€10mg130.00€25mg219.00€50mg324.00€100mg462.00€200mg655.00€1mL*10mM (DMSO)96.00€Nateglinide D5
CAS:Nateglinide D5 is a deuterium labeled Nateglinide.Formula:C19H27NO3Purity:98%Color and Shape:SolidMolecular weight:322.45QO-58
CAS:QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory painFormula:C18H8Cl2F4N4OPurity:99.17%Color and Shape:SolidMolecular weight:443.18Flecainide
CAS:Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.Formula:C17H20F6N2O3Purity:99.896%Color and Shape:SolidMolecular weight:414.34Ref: TM-T21391
5mg46.00€10mg66.00€25mg111.00€50mg177.00€100mg268.00€200mg335.00€1mL*10mM (DMSO)49.00€Clamikalant sodium
CAS:Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.Formula:C19H21ClN3NaO5S2Purity:99.95%Color and Shape:SolidMolecular weight:493.96Ref: TM-T63330
1mg48.00€5mg90.00€10mg172.00€25mg346.00€50mg546.00€100mg855.00€200mg1,170.00€1mL*10mM (DMSO)99.00€ICA-069673
CAS:ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).Formula:C11H6ClF2N3OPurity:99.04% - 99.68%Color and Shape:SolidMolecular weight:269.63A2793
CAS:A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM.Formula:C13H12ClNO3Purity:98.54%Color and Shape:SolidMolecular weight:265.69Mitiglinide calcium hydrate
CAS:Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes.Formula:C38H52CaN2O8Purity:98.97% - 99.96%Color and Shape:White SolidMolecular weight:704.91Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purity:99.33% - 99.86%Color and Shape:SolidMolecular weight:316.35
