Potassium Channel
Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.
Found 276 products of "Potassium Channel"
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Dendrotoxin K TFA
<p>Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].</p>Formula:C294H462N84O75S6·XC2HF3OC2Purity:98%Color and Shape:SolidMolecular weight:6559.66 (free base)BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formula:C22H23F7N2O3Color and Shape:SolidMolecular weight:496.418Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formula:C19H23F2N3O2Color and Shape:SolidMolecular weight:363.4KNa1.1-IN-2
CAS:<p>KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.</p>Formula:C24H27NOColor and Shape:SolidMolecular weight:345.48Vesnarinone HCl
<p>Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.</p>Formula:C22H26ClN3O4Purity:99.17%Color and Shape:SoildMolecular weight:431.91Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Formula:C17H19F2N3O2Color and Shape:SolidMolecular weight:335.349Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Formula:C179H274N50O55S7Purity:98%Color and Shape:SolidMolecular weight:4230Cromakalim
CAS:<p>Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.</p>Formula:C16H18N2O3Purity:99.39%Color and Shape:SolidMolecular weight:286.33Nateglinide D5
CAS:<p>Nateglinide D5 is a deuterium labeled Nateglinide.</p>Formula:C19H27NO3Purity:98%Color and Shape:SolidMolecular weight:322.45QO-58
CAS:<p>QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory pain</p>Formula:C18H8Cl2F4N4OPurity:99.17%Color and Shape:SolidMolecular weight:443.18Flecainide
CAS:<p>Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.</p>Formula:C17H20F6N2O3Purity:99.896%Color and Shape:SolidMolecular weight:414.34Neosolaniol
CAS:<p>Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.</p>Formula:C19H26O8Purity:98%Color and Shape:SolidMolecular weight:382.4KCNQ1 activator-1
CAS:<p>N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.</p>Formula:C22H23N3O4S2Purity:99.71%Color and Shape:SolidMolecular weight:457.57Endoxifen Z-isomer hydrochloride
CAS:<p>Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.</p>Formula:C25H28ClNO2Color and Shape:SolidMolecular weight:409.95Clamikalant sodium
CAS:<p>Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.</p>Formula:C19H21ClN3NaO5S2Purity:99.95%Color and Shape:SolidMolecular weight:493.96Oxypeucedanin
CAS:<p>1.</p>Formula:C16H14O5Purity:98.66% - 98.85%Color and Shape:SolidMolecular weight:286.28Ibutilide Fumarate
CAS:<p>Ibutilide Fumarate is a class III antiarrhythmic, prolonging action potentials by enhancing sodium influx, and can extend QT interval.</p>Formula:(C20H36N2O3S)2·C4H4O4Purity:99.68% - 99.74%Color and Shape:SolidMolecular weight:885.23Guanosine 5'-diphosphate disodium salt
CAS:<p>5'-GDP-Na2: a nucleoside diphosphate, iron mobilizer, blocks hepcidin-ferroportin, affects IL-6/stat-3.</p>Formula:C10H13N5Na2O11P2Purity:99.40%Color and Shape:White PowderMolecular weight:487.16XE 991 dihydrochloride
CAS:<p>XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker.</p>Formula:C26H22Cl2N2OPurity:98.68%Color and Shape:SolidMolecular weight:449.37SKA-31
CAS:<p>SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).</p>Formula:C11H8N2SPurity:99.38%Color and Shape:SolidMolecular weight:200.26Ropivacaine hydrochloride monohydrate
CAS:<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Formula:C17H29ClN2O2Purity:99.94% - 99.95%Color and Shape:White SolidMolecular weight:328.88Cholesterol myristate
CAS:<p>Cholesterol myristate, a natural steroid in Chinese medicine, affects GABAA, nicotinic receptors, and potassium channels.</p>Formula:C41H72O2Purity:99.65%Color and Shape:SolidMolecular weight:597.01Quinidine sulfate dihydrate
CAS:<p>Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor</p>Formula:C40H54N4O10SPurity:99.85%Color and Shape:White To Light Yellow Crystal PowdeMolecular weight:782.9ML277
CAS:<p>ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).</p>Formula:C23H25N3O4S2Purity:99.35%Color and Shape:SolidMolecular weight:471.59APD668
CAS:<p>APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.</p>Formula:C21H24FN5O5SPurity:99.74% - 99.97%Color and Shape:SolidMolecular weight:477.51Amifampridine
CAS:<p>Amifampridine blocks nerve potassium channels, extends action potentials, boosts acetylcholine release, and treats rare muscle diseases.</p>Formula:C5H7N3Purity:99.82%Color and Shape:Slightly Beige PowderMolecular weight:109.13TKIM
CAS:<p>TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.</p>Formula:C18H14ClN3O2SPurity:99.47%Color and Shape:SolidMolecular weight:371.84ICA-069673
CAS:<p>ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).</p>Formula:C11H6ClF2N3OPurity:99.04% - 99.68%Color and Shape:SolidMolecular weight:269.63NS309
CAS:<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Formula:C8H4Cl2N2O2Purity:97.55%Color and Shape:SolidMolecular weight:231.04BAPTA-AM
CAS:<p>BAPTA-AM is a calcium chelator that is cell-permeable and selective, blocking hERG, hKv1.3, and hKv1.5 channels (IC50=1.3/1.45/1.23 μM).</p>Formula:C34H40N2O18Purity:98% - 99.47%Color and Shape:White Powder Or Crystalline PowderMolecular weight:764.68Quinidine
CAS:<p>Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.</p>Formula:C20H24N2O2Purity:97.03% - 99.99%Color and Shape:Crystals With 2 5 Mol Water Of Crystallization; Crystals From Dilute Alcohol Physical Description Crystals Or White Powder (Ntp 1992)Molecular weight:324.42Talatisamine
CAS:<p>Talatisamine and TEA mitigate Aβ oligomer effects on I(K), bolstering cell survival and reducing K(+) loss-induced apoptosis; promising for further study.</p>Formula:C24H39NO5Purity:98.62% - 99.44%Color and Shape:SolidMolecular weight:421.57VU0134992
CAS:<p>VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM</p>Formula:C20H31BrN2O2Purity:99.86%Color and Shape:SolidMolecular weight:411.38Endoxifen (Z-isomer)
CAS:<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Formula:C25H27NO2Purity:99.19% - 99.81%Color and Shape:SolidMolecular weight:373.49Paederosidic acid methyl ester
CAS:<p>Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.</p>Formula:C19H26O12SPurity:99.67% - 99.91%Color and Shape:SolidMolecular weight:478.4720(S)-Ginsenoside Rg3
CAS:<p>20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.</p>Formula:C42H72O13Purity:98.11% - 99.93%Color and Shape:SolidMolecular weight:785.01KCNQ2/3 activator-1
CAS:<p>KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator.</p>Formula:C23H29FN2OPurity:99.16% - 99.47%Color and Shape:SolidMolecular weight:368.492,2,2-Trichloroethanol
CAS:<p>2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.</p>Formula:C2H3Cl3OPurity:99.74%Color and Shape:LiquidMolecular weight:149.4Yoda 1
CAS:<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Formula:C13H8Cl2N4S2Purity:98% - 99.98%Color and Shape:SolidMolecular weight:355.27Quinine hydrochloride dihydrate
CAS:<p>Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.</p>Formula:C20H24N2O2·HCl·2H2OPurity:99.91%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:396.91Kv2-IN-A1
CAS:<p>Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.</p>Formula:C20H17ClN4OSPurity:98.83%Color and Shape:SolidMolecular weight:396.89Almitrine mesylate
CAS:<p>Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.</p>Formula:C28H37F2N7O6S2Purity:99.96%Color and Shape:CoaMolecular weight:669.76Azimilide Dihydrochloride
CAS:<p>Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the IKs and IKr with antiarrhythmic activity.</p>Formula:C23H30Cl3N5O3Purity:97.59% - ≥95%Color and Shape:SolidMolecular weight:530.88ML365
CAS:<p>ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).</p>Formula:C22H20N2O3Purity:98.78%Color and Shape:SolidMolecular weight:360.41VU0071063
CAS:<p>VU0071063 is a Kir6.2/SUR1 activator.</p>Formula:C18H22N4O2Purity:99.33%Color and Shape:SolidMolecular weight:326.39Quinine dihydrochloride
CAS:<p>Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae).</p>Formula:C20H26Cl2N2O2Purity:99.79% - 99.97%Color and Shape:White SolidMolecular weight:397.34Sematilide hydrochloride
CAS:<p>Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.</p>Formula:C14H24ClN3O3SPurity:99.14%Color and Shape:SolidMolecular weight:349.87Dofetilide
CAS:<p>Dofetilide (UK 68789), a class III antiarrhythmic sulfonamide, blocks Ikr cardiac channels, prolongs action potential, and treats atrial fibrillation/flutter.</p>Formula:C19H27N3O5S2Purity:97.85% - 99.06%Color and Shape:Off-White Or Yellowish Crystalline PowderMolecular weight:441.56AUT1
CAS:<p>AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).</p>Formula:C18H19N3O4Purity:99.8% - 99.95%Color and Shape:SolidMolecular weight:341.36Iptakalim Hydrochloride
CAS:<p>Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine</p>Formula:C9H22ClNPurity:98%Color and Shape:SolidMolecular weight:179.731
