P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Found 54 products of "P-gp"
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Piperine
CAS:<p>Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.</p>Formula:C17H19NO3Purity:98.41% - 98.51%Color and Shape:SolidMolecular weight:285.34Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494.00Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formula:C27H39ClN2O4Purity:98.7% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:491.06Atazanavir
CAS:<p>Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.</p>Formula:C38H52N6O7Purity:98% - 99.95%Color and Shape:Crystalline SolidMolecular weight:704.86(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormula:C30H52O3Purity:97.07% - 98.91%Color and Shape:SolidMolecular weight:460.73Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formula:C26H37ClN2O4Purity:99.47%Color and Shape:SolidMolecular weight:477.04Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formula:C38H52N6O7·H2SO4Purity:99.31% - 99.40%Color and Shape:SolidMolecular weight:802.93Encequidar mesylate
CAS:<p>Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.</p>Formula:C39H40N6O10SPurity:99.84%Color and Shape:SolidMolecular weight:784.83Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formula:C21H21F2N3OSPurity:99.58%Color and Shape:SolidMolecular weight:401.47Dofequidar fumarate
CAS:<p>Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the</p>Formula:C34H35N3O7Purity:99.93%Color and Shape:SolidMolecular weight:597.66Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formula:C23H27FN4O2Purity:99.73%Color and Shape:Crystalline SolidMolecular weight:410.48Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurity:99.57% - 99.96%Color and Shape:Cream Fine PowderMolecular weight:480.43Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formula:C40H58N4O18S2Purity:98.13%Color and Shape:SolidMolecular weight:947.04YS-370
CAS:<p>YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.</p>Formula:C37H35BrN4O3Purity:98.055%Color and Shape:SolidMolecular weight:663.6WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Molecular weight:355.44P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Formula:C41H36N4O8Molecular weight:712.75CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Formula:C111H131N23O30SColor and Shape:SolidMolecular weight:2299.43Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purity:95% - >99.99%Color and Shape:SolidMolecular weight:1214.62P-gp inhibitor 14
CAS:Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Formula:C37H38N2O8Color and Shape:SolidMolecular weight:638.71P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formula:C30H28N2O6Purity:99.85%Color and Shape:SoildMolecular weight:512.55
