P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
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Verapamil
CAS:52-53-9
Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, …
Formula:
C27H38N2O4
Purity:
99.53%
Color and Shape:
Oil
Molecular weight:
454.6
Ref: TM-T20656
| 10mg | 35.00 € | ||
| 25mg | 51.00 € | ||
| 50mg | 72.00 € | ||
| 100mg | 99.00 € | ||
| 200mg | 142.00 € | ||
| 500mg | 226.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
MCI826
CAS:140646-80-6
MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing …
Formula:
C22H28N2O3S
Purity:
98.73%
Color and Shape:
Solid
Molecular weight:
400.53
Ref: TM-T16026
| 1mg | 650.00 € | ||
| 5mg | 1,672.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
P-gp inhibitor 1
CAS:2050747-49-2
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 …
Formula:
C32H31N5O2
Purity:
98.65%
Color and Shape:
Solid
Molecular weight:
517.62
Ref: TM-T12341
| 1mg | 36.00 € | ||
| 5mg | 82.00 € | ||
| 10mg | 122.00 € | ||
| 25mg | 238.00 € | ||
| 50mg | 356.00 € | ||
| 100mg | 496.00 € | ||
| 500mg | 1,012.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
coniferyl ferulate
CAS:63644-62-2
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.
Formula:
C20H20O6
Purity:
97.09%
Color and Shape:
Solid
Molecular weight:
356.37
Ref: TM-T3S0012
| 1mg | 52.00 € | ||
| 5mg | 113.00 € | ||
| 10mg | 193.00 € | ||
| 25mg | 321.00 € | ||
| 50mg | 458.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Dofequidar
CAS:129716-58-1
Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
Formula:
C30H31N3O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
481.59
Ref: TM-TQ0043
| 1mg | 108.00 € | ||
| 5mg | 332.00 € | ||
| 10mg | 610.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
PGP-4008
CAS:365565-02-2
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration …
Formula:
C26H23N3O
Purity:
98% - 98.53%
Color and Shape:
Solid
Molecular weight:
393.48
Ref: TM-T28396
| 1mg | 69.00 € | ||
| 5mg | 158.00 € | ||
| 10mg | 245.00 € | ||
| 25mg | 462.00 € | ||
| 50mg | 737.00 € | ||
| 100mg | 1,095.00 € | ||
| 500mg | 2,218.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
