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P-gp

P-gp

P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.

Found 53 products of "P-gp"

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  • Talinolol
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    Talinolol

    CAS:
    <p>(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.</p>
    Formula:C20H33N3O3
    Purity:98.8%
    Color and Shape:Solid
    Molecular weight:363.49

    Ref: TM-T21640

  • Elacridar
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    Elacridar

    CAS:
    <p>Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.</p>
    Formula:C34H33N3O5
    Purity:98.12% - >99.99%
    Color and Shape:Solid
    Molecular weight:563.64

    Ref: TM-T2657

  • Chrysosplenetin
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    Chrysosplenetin

    CAS:
    <p>Chrysosplenetin is a metabolic inhibitor of artemisinin.</p>
    Formula:C19H18O8
    Purity:97.43% - 98.4%
    Color and Shape:Solid
    Molecular weight:374.34

    Ref: TM-TJS1159

  • HTT-D3
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    HTT-D3

    CAS:
    <p>HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.</p>
    Formula:C23H25FN6
    Purity:99.31%
    Color and Shape:Solid
    Molecular weight:404.48

    Ref: TM-T61991

  • Verapamil
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    Verapamil

    CAS:
    <p>Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.</p>
    Formula:C27H38N2O4
    Purity:99.61% - 99.93%
    Color and Shape:Oil
    Molecular weight:454.6

    Ref: TM-T20656

  • ONT-093
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    ONT-093

    CAS:
    <p>ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.</p>
    Formula:C32H38N4O
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:494.67

    Ref: TM-T63338

  • P-gp inhibitor 1
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    P-gp inhibitor 1

    CAS:
    <p>P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).</p>
    Formula:C32H31N5O2
    Purity:98.65%
    Color and Shape:Solid
    Molecular weight:517.62

    Ref: TM-T12341

  • PGP-4008
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    PGP-4008

    CAS:
    <p>PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.</p>
    Formula:C26H23N3O
    Purity:98.07% - 98.95%
    Color and Shape:Solid
    Molecular weight:393.48

    Ref: TM-T28396

  • P-gp inhibitor 17
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    P-gp inhibitor 17

    CAS:
    <p>P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].</p>
    Formula:C36H49N3O3
    Color and Shape:Solid
    Molecular weight:571.79

    Ref: TM-T87138

  • coniferyl ferulate
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    coniferyl ferulate

    CAS:
    <p>Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.</p>
    Formula:C20H20O6
    Purity:99.39%
    Color and Shape:Solid
    Molecular weight:356.37

    Ref: TM-T3S0012

  • MCI826
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    MCI826

    CAS:
    <p>MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model of</p>
    Formula:C22H28N2O3S
    Purity:98.73%
    Color and Shape:Solid
    Molecular weight:400.53

    Ref: TM-T16026

  • 8-Prenylchrysin
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    8-Prenylchrysin

    CAS:
    <p>8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.</p>
    Formula:C20H18O4
    Color and Shape:Solid
    Molecular weight:322.354

    Ref: TM-T204259

  • NSC73306
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    NSC73306

    CAS:
    <p>NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.</p>
    Formula:C16H14N4O2S
    Color and Shape:Solid
    Molecular weight:326.373

    Ref: TM-T204744