P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Found 64 products for "P-gp".
Filter by
Purity percentage
0
100
|
0
|
50
|
90
|
95
|
100
- Lower prices
- Higher prices
- Lower purities
- Higher purities
- Faster estimated delivery
WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Color and Shape:SolidMolecular weight:355.44P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Formula:C41H36N4O8Color and Shape:SolidMolecular weight:712.75Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formula:C40H52N4O15S2Purity:98.13%Color and Shape:Yellow SolidMolecular weight:892.989P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Formula:C19H16N2O5Color and Shape:SolidMolecular weight:352.34P-gp-IN-33
P-gp-IN-33 (Compound 17a) functions as a P-gp inhibitor. This compound binds to the Verapamil binding pocket of P-gp. P-gp-IN-33 exhibits higher cytotoxicity against resistant non-small cell lung cancer cells compared to non-resistant ones.Antitrypanosomal agent 24
Antitrypanosomal agent 24 is a benzothiazole amidoxime compound with potent and selective activity against trypanosomes (IC50 = 0.92 μM). It serves as a substrate for the P-glycoprotein efflux pump and exhibits high membrane permeability and good metabolic stability. Antitrypanosomal agent 24 binds to DNA/RNA via intercalation.Evodine
CAS:1. Evodine has antinociceptive activity.Formula:C18H19NO5Purity:98%Color and Shape:SolidMolecular weight:329.3472YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formula:C37H35BrN4O3Purity:98.05%Color and Shape:SolidMolecular weight:663.603Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formula:C39H37F3N4O5Purity:99.85%Color and Shape:SoildMolecular weight:698.73Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Formula:C43H52N4O5Purity:98.54% - 99.97%Color and Shape:White SolidMolecular weight:704.8968Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Formula:C11H10N4S3Purity:99.15%Color and Shape:SolidMolecular weight:294.419Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.57% - 99.63%Color and Shape:SolidMolecular weight:1031.1842Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formula:C20H40O3Purity:n~9-10Color and Shape:SolidMolecular weight:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formula:C20H20O7Purity:99.98% - ≥95%Color and Shape:SolidMolecular weight:372.3686Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formula:C38H38N4O6Purity:98.07% - 99.45%Color and Shape:Yellow SolidMolecular weight:646.7315Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purity:99.84%Color and Shape:Yellow SolidMolecular weight:769.9604Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formula:C26H30O11Purity:97.91%Color and Shape:White SolidMolecular weight:518.5098Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formula:C16H24NO5Purity:98% - 99.96%Color and Shape:White Or Light-Tan SolidMolecular weight:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27% - 99.53%Color and Shape:SolidMolecular weight:550.6378Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formula:C32H31F2N3O2·3HClPurity:99.49% - >99.99%Color and Shape:Yellow SolidMolecular weight:636.99
