P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Found 53 products of "P-gp"
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FM04
CAS:<p>FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.</p>Formula:C26H25NO4Purity:99.77%Color and Shape:SolidMolecular weight:415.48Solamargine
CAS:<p>Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.</p>Formula:C45H73NO15Purity:99.17% - 99.96%Color and Shape:SolidMolecular weight:868.06Ceefourin 1
CAS:<p>Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.</p>Formula:C11H10N4S3Purity:99.15%Color and Shape:SolidMolecular weight:294.42Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Polyoxyethylene stearate
CAS:<p>Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.</p>Formula:C20H40O3Purity:n~9-10Color and Shape:Light Amber SemisolidMolecular weight:328.29775Isosinensetin
CAS:<p>1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.</p>Formula:C20H20O7Purity:99.05% - ≥95%Color and Shape:SolidMolecular weight:372.37Voacamine
CAS:<p>Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.</p>Formula:C43H52N4O5Purity:98.54% - 99.82%Color and Shape:SolidMolecular weight:704.9Tariquidar
CAS:<p>Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.</p>Formula:C38H38N4O6Purity:98.07% - 99.45%Color and Shape:SolidMolecular weight:646.73Selamectin
CAS:<p>Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in</p>Formula:C43H63NO11Purity:99.84%Color and Shape:SolidMolecular weight:769.96Phellamurin
CAS:<p>Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.</p>Formula:C26H30O11Purity:97.91%Color and Shape:SolidMolecular weight:518.51Sinapine
CAS:<p>Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.</p>Formula:C16H24NO5Purity:98% - 99.68%Color and Shape:White Or Light-Tan SolidMolecular weight:310.37Convallatoxin
CAS:<p>Convallatoxin is a natural product.</p>Formula:C29H42O10Purity:99.27% - 99.53%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64Zosuquidar trihydrochloride
CAS:<p>Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.</p>Formula:C32H31F2N3O2·3HClPurity:99.49% - >99.99%Color and Shape:SolidMolecular weight:636.99Hypophyllanthin
CAS:<p>Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.</p>Formula:C24H30O7Purity:98.39%Color and Shape:SolidMolecular weight:430.49Zosuquidar
CAS:<p>Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.</p>Formula:C32H31F2N3O2Color and Shape:SolidMolecular weight:527.6HM-30181 mesylate monohydrate
CAS:<p>HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.</p>Formula:C39H42N6O11SPurity:99.37%Color and Shape:SolidMolecular weight:802.85Encequidar
CAS:<p>Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.</p>Formula:C38H36N6O7Purity:99.93%Color and Shape:SolidMolecular weight:688.73Trifluoperazine
CAS:<p>Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.</p>Formula:C21H24F3N3SPurity:98.3% - 99.46%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:407.5γ-Tocotrienol
CAS:<p>γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.</p>Formula:C28H42O2Purity:97.27% - 98.13%Color and Shape:SolidMolecular weight:410.63Sinapine thiocyanate
CAS:<p>Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.</p>Formula:C16H24NO5·CNSPurity:99.79% - ≥95%Color and Shape:SolidMolecular weight:368.45
