P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Found 55 products of "P-gp"
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Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formula:C39H37F3N4O5Purity:99.85%Color and Shape:SoildMolecular weight:698.73WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Color and Shape:SolidMolecular weight:355.44Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purity:95% - >99.99%Color and Shape:SolidMolecular weight:1214.62P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Formula:C41H36N4O8Molecular weight:712.75Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formula:C45H73NO15Purity:99.17% - 99.96%Color and Shape:SolidMolecular weight:868.06Ref: TM-T4034
1mg56.00€2mg78.00€5mg109.00€10mg165.00€25mg289.00€50mg434.00€100mg655.00€200mg883.00€1mL*10mM (DMSO)158.00€Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Formula:C11H10N4S3Purity:99.15%Color and Shape:SolidMolecular weight:294.42Ref: TM-T8596
1mg43.00€5mg88.00€10mg119.00€25mg250.00€50mg389.00€100mg550.00€200mg785.00€1mL*10mM (DMSO)87.00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formula:C20H40O3Purity:n~9-10Color and Shape:Light Amber SemisolidMolecular weight:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formula:C20H20O7Purity:99.98% - ≥95%Color and Shape:SolidMolecular weight:372.37Ref: TM-T2S0223
1mg63.00€5mg135.00€10mg195.00€25mg326.00€50mg485.00€100mg700.00€1mL*10mM (DMSO)165.00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.
Formula:C43H52N4O5Purity:98.54% - 99.82%Color and Shape:SolidMolecular weight:704.9Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formula:C38H38N4O6Purity:98.07% - 99.45%Color and Shape:SolidMolecular weight:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purity:99.84%Color and Shape:SolidMolecular weight:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formula:C26H30O11Purity:97.91%Color and Shape:SolidMolecular weight:518.51Ref: TM-TN4761
1mg155.00€5mg304.00€10mg447.00€25mg713.00€50mg1,018.00€100mg1,369.00€1mL*10mM (DMSO)389.00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formula:C16H24NO5Purity:98% - 99.68%Color and Shape:White Or Light-Tan SolidMolecular weight:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27% - 99.53%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formula:C32H31F2N3O2·3HClPurity:99.49% - >99.99%Color and Shape:SolidMolecular weight:636.99Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Formula:C24H30O7Purity:98.39%Color and Shape:SolidMolecular weight:430.49Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formula:C32H31F2N3O2Purity:99.99%Color and Shape:SolidMolecular weight:527.6Ref: TM-T6018L
1mg73.00€5mg152.00€10mg220.00€25mg358.00€50mg537.00€100mg782.00€200mg1,071.00€1mL*10mM (DMSO)170.00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formula:C39H42N6O11SPurity:99.37%Color and Shape:SolidMolecular weight:802.85Ref: TM-T9173
1mg65.00€2mg94.00€5mg119.00€10mg185.00€25mg309.00€50mg442.00€100mg643.00€200mg835.00€500mg1,251.00€1mL*10mM (DMSO)177.00€Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Formula:C38H36N6O7Purity:99.93%Color and Shape:SolidMolecular weight:688.73Ref: TM-T8426
1mg46.00€2mg62.00€5mg90.00€10mg137.00€25mg234.00€50mg360.00€100mg528.00€1mL*10mM (DMSO)127.00€
