P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Found 55 products of "P-gp"
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Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formula:C26H37ClN2O4Purity:99.47%Color and Shape:SolidMolecular weight:477.04Ref: TM-T16339
1mg34.00€5mg105.00€10mg177.00€25mg299.00€50mg447.00€100mg602.00€200mg842.00€1mL*10mM (DMSO)110.00€Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formula:C21H21F2N3OSPurity:99.58%Color and Shape:SolidMolecular weight:401.47Ref: TM-T13383
1mg92.00€5mg193.00€10mg293.00€25mg528.00€50mg795.00€100mg1,153.00€1mL*10mM (DMSO)210.00€Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formula:C23H27FN4O2Purity:99.73%Color and Shape:Crystalline SolidMolecular weight:410.48Ref: TM-T0351
10mg48.00€25mg56.00€50mg88.00€100mg122.00€200mg192.00€500mg323.00€1mL*10mM (DMSO)50.00€Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494.00Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurity:99.57% - 99.96%Color and Shape:Cream Fine PowderMolecular weight:480.43Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Formula:C17H19NO3Purity:98.41% - 98.51%Color and Shape:SolidMolecular weight:285.34Dofequidar fumarate
CAS:Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the
Formula:C34H35N3O7Purity:99.93%Color and Shape:SolidMolecular weight:597.66Ref: TM-T11071
1mg39.00€2mg50.00€5mg85.00€10mg125.00€25mg245.00€50mg472.00€100mg687.00€500mg1,444.00€Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
Formula:C39H40N6O10SPurity:99.84%Color and Shape:SolidMolecular weight:784.83Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formula:C38H52N6O7·H2SO4Purity:99.31% - 99.40%Color and Shape:SolidMolecular weight:802.93Ref: TM-T0100
5mg44.00€10mg58.00€25mg90.00€50mg114.00€100mg170.00€200mg250.00€500mg425.00€1mL*10mM (DMSO)50.00€(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormula:C30H52O3Purity:97.07% - 98.91%Color and Shape:SolidMolecular weight:460.73Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Formula:C38H52N6O7Purity:98% - 99.95%Color and Shape:Crystalline SolidMolecular weight:704.86Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formula:C27H39ClN2O4Purity:98.7% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:491.06P-gp inhibitor 14
CAS:Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Formula:C37H38N2O8Color and Shape:SolidMolecular weight:638.71P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Formula:C19H16N2O5Color and Shape:SolidMolecular weight:352.34Evodine
CAS:1. Evodine has antinociceptive activity.Formula:C18H19NO5Purity:98%Color and Shape:SolidMolecular weight:329.35CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Formula:C111H131N23O30SColor and Shape:SolidMolecular weight:2299.43FM04
CAS:FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Formula:C26H25NO4Purity:99.87%Color and Shape:SolidMolecular weight:415.48P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formula:C30H28N2O6Purity:99.85%Color and Shape:SoildMolecular weight:512.55Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formula:C40H58N4O18S2Purity:98.13%Color and Shape:SolidMolecular weight:947.04YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formula:C37H35BrN4O3Purity:98.055%Color and Shape:SolidMolecular weight:663.6Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formula:C39H37F3N4O5Purity:99.85%Color and Shape:SoildMolecular weight:698.73WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Color and Shape:SolidMolecular weight:355.44Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purity:95% - >99.99%Color and Shape:SolidMolecular weight:1214.62P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Formula:C41H36N4O8Molecular weight:712.75Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formula:C45H73NO15Purity:99.17% - 99.96%Color and Shape:SolidMolecular weight:868.06Ref: TM-T4034
1mg56.00€2mg78.00€5mg109.00€10mg165.00€25mg289.00€50mg434.00€100mg655.00€200mg883.00€1mL*10mM (DMSO)158.00€Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Formula:C11H10N4S3Purity:99.15%Color and Shape:SolidMolecular weight:294.42Ref: TM-T8596
1mg43.00€5mg88.00€10mg119.00€25mg250.00€50mg389.00€100mg550.00€200mg785.00€1mL*10mM (DMSO)87.00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formula:C20H40O3Purity:n~9-10Color and Shape:Light Amber SemisolidMolecular weight:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formula:C20H20O7Purity:99.98% - ≥95%Color and Shape:SolidMolecular weight:372.37Ref: TM-T2S0223
1mg63.00€5mg135.00€10mg195.00€25mg326.00€50mg485.00€100mg700.00€1mL*10mM (DMSO)165.00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.
Formula:C43H52N4O5Purity:98.54% - 99.82%Color and Shape:SolidMolecular weight:704.9Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formula:C38H38N4O6Purity:98.07% - 99.45%Color and Shape:SolidMolecular weight:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purity:99.84%Color and Shape:SolidMolecular weight:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formula:C26H30O11Purity:97.91%Color and Shape:SolidMolecular weight:518.51Ref: TM-TN4761
1mg155.00€5mg304.00€10mg447.00€25mg713.00€50mg1,018.00€100mg1,369.00€1mL*10mM (DMSO)389.00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formula:C16H24NO5Purity:98% - 99.68%Color and Shape:White Or Light-Tan SolidMolecular weight:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27% - 99.53%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formula:C32H31F2N3O2·3HClPurity:99.49% - >99.99%Color and Shape:SolidMolecular weight:636.99Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Formula:C24H30O7Purity:98.39%Color and Shape:SolidMolecular weight:430.49Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formula:C32H31F2N3O2Purity:99.99%Color and Shape:SolidMolecular weight:527.6Ref: TM-T6018L
1mg73.00€5mg152.00€10mg220.00€25mg358.00€50mg537.00€100mg782.00€200mg1,071.00€1mL*10mM (DMSO)170.00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formula:C39H42N6O11SPurity:99.37%Color and Shape:SolidMolecular weight:802.85Ref: TM-T9173
1mg65.00€2mg94.00€5mg119.00€10mg185.00€25mg309.00€50mg442.00€100mg643.00€200mg835.00€500mg1,251.00€1mL*10mM (DMSO)177.00€Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Formula:C38H36N6O7Purity:99.93%Color and Shape:SolidMolecular weight:688.73Ref: TM-T8426
1mg46.00€2mg62.00€5mg90.00€10mg137.00€25mg234.00€50mg360.00€100mg528.00€1mL*10mM (DMSO)127.00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurity:98.3% - 99.46%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:407.5γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formula:C28H42O2Purity:97.27% - 98.13%Color and Shape:SolidMolecular weight:410.63Ref: TM-T19768
1mg44.00€2mg58.00€5mg96.00€10mg137.00€25mg224.00€50mg333.00€100mg489.00€200mg705.00€1mL*10mM (DMSO)92.00€Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formula:C16H24NO5·CNSPurity:99.79% - ≥95%Color and Shape:SolidMolecular weight:368.45Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formula:C20H33N3O3Purity:98.8%Color and Shape:SolidMolecular weight:363.49Ref: TM-T21640
2mg34.00€5mg52.00€10mg92.00€25mg178.00€50mg313.00€100mg535.00€200mg775.00€1mL*10mM (DMSO)52.00€Elacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Formula:C34H33N3O5Purity:98.12% - >99.99%Color and Shape:SolidMolecular weight:563.64Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Formula:C19H18O8Purity:97.43% - 98.4%Color and Shape:SolidMolecular weight:374.34Ref: TM-TJS1159
1mg57.00€5mg120.00€10mg178.00€25mg329.00€50mg485.00€100mg692.00€500mg1,404.00€1mL*10mM (DMSO)215.00€HTT-D3
CAS:HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.
Formula:C23H25FN6Purity:99.31%Color and Shape:SolidMolecular weight:404.48Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formula:C27H38N2O4Purity:99.61% - 99.93%Color and Shape:OilMolecular weight:454.6Ref: TM-T20656
10mg35.00€25mg51.00€50mg73.00€100mg96.00€200mg143.00€500mg230.00€1mL*10mM (DMSO)55.00€P-gp inhibitor 1
CAS:P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Formula:C32H31N5O2Purity:98.65%Color and Shape:SolidMolecular weight:517.62Ref: TM-T12341
5mg50.00€10mg84.00€25mg150.00€50mg219.00€100mg304.00€200mg419.00€1mL*10mM (DMSO)58.00€P-gp inhibitor 17
CAS:P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Formula:C36H49N3O3Color and Shape:SolidMolecular weight:571.79ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Formula:C32H38N4OPurity:98.86%Color and Shape:SolidMolecular weight:494.67coniferyl ferulate
CAS:Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Formula:C20H20O6Purity:99.39%Color and Shape:SolidMolecular weight:356.37PGP-4008
CAS:PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Formula:C26H23N3OPurity:97.41% - 97.99%Color and Shape:SolidMolecular weight:393.488-Prenylchrysin
CAS:8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.Formula:C20H18O4Color and Shape:SolidMolecular weight:322.354NSC73306
CAS:NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.Formula:C16H14N4O2SColor and Shape:SolidMolecular weight:326.373
