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Sodium Channel

Sodium Channel

Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.

Found 202 products of "Sodium Channel"

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  • Sodium Channel inhibitor 4
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    Sodium Channel inhibitor 4

    CAS:
    <p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>
    Formula:C19H18ClN3O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:451.95

    Ref: TM-T81134

  • Co 102862
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    Co 102862

    CAS:
    <p>Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.</p>
    Formula:C14H12FN3O2
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:273.26

    Ref: TM-T22675

  • GDC-0310
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    GDC-0310

    CAS:
    <p>GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.</p>
    Formula:C25H29Cl2FN2O4S
    Purity:99.877%
    Color and Shape:Solid
    Molecular weight:543.48

    Ref: TM-T39208

  • 6-Iodoamiloride
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    6-Iodoamiloride

    CAS:
    <p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>
    Formula:C6H8IN7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:321.08

    Ref: TM-T79246

  • Aneratrigine hydrochloride
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    Aneratrigine hydrochloride

    CAS:
    <p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>
    Formula:C19H21Cl2F2N5O2S2
    Purity:98.37% - 99.16%
    Color and Shape:Solid
    Molecular weight:524.43

    Ref: TM-T79835

  • VGSCs-IN-1
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    VGSCs-IN-1

    CAS:
    <p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>
    Formula:C12H12F3N3OS
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:303.3

    Ref: TM-T80626

  • Funapide
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    Funapide

    CAS:
    <p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>
    Formula:C22H14F3NO5
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:429.35

    Ref: TM-T15358

  • PF-05661014
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    PF-05661014

    CAS:
    <p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>
    Formula:C17H16N4O3S2
    Color and Shape:Solid
    Molecular weight:388.46

    Ref: TM-T89885

  • Olisutrigine bromide
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    Olisutrigine bromide

    CAS:
    <p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>
    Formula:C25H35BrN2
    Color and Shape:Solid
    Molecular weight:443.463

    Ref: TM-T205479

  • N-Depropylpropafenone
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    N-Depropylpropafenone

    CAS:
    <p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>
    Formula:C18H21NO3
    Color and Shape:Solid
    Molecular weight:299.36

    Ref: TM-T201563

  • Vormatrigine
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    Vormatrigine

    CAS:
    <p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>
    Formula:C16H12F6N4O2
    Color and Shape:Solid
    Molecular weight:406.28

    Ref: TM-T201328

  • Tizolemide
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    Tizolemide

    CAS:
    <p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>
    Formula:C11H14ClN3O3S2
    Color and Shape:Solid
    Molecular weight:335.83

    Ref: TM-T201590

  • Lubeluzole dihydrochloride
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    Lubeluzole dihydrochloride

    CAS:
    <p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>
    Formula:C22H27Cl2F2N3O2S
    Color and Shape:Solid
    Molecular weight:506.44

    Ref: TM-T200178

  • Quinacainol dihydrochloride
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    Quinacainol dihydrochloride

    CAS:
    <p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>
    Formula:C21H32Cl2N2O
    Color and Shape:Solid
    Molecular weight:399.398

    Ref: TM-T204878

  • Zilvetrigine
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    Zilvetrigine

    CAS:
    <p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>
    Formula:C20H20ClN3O2
    Color and Shape:Solid
    Molecular weight:369.845

    Ref: TM-T205304

  • (R)-Duloxetine
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    (R)-Duloxetine

    CAS:
    <p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>
    Formula:C18H19NOS
    Color and Shape:Solid
    Molecular weight:297.42

    Ref: TM-T200895

  • Olorigliflozin
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    Olorigliflozin

    CAS:
    <p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>
    Formula:C23H27ClO7
    Color and Shape:Solid
    Molecular weight:450.909

    Ref: TM-T205428

  • ErSO-TFPy
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    ErSO-TFPy

    CAS:
    <p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>
    Formula:C19H13F7N2O2
    Color and Shape:Solid
    Molecular weight:434.307

    Ref: TM-T205320

  • Suzetrigine
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    Suzetrigine

    CAS:
    <p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>
    Formula:C21H20F5N3O4
    Purity:98.08% - 99.27%
    Color and Shape:Solid
    Molecular weight:473.39

    Ref: TM-T69552

  • SYM2206
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    SYM2206

    CAS:
    <p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>
    Formula:C20H22N4O3
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:366.41

    Ref: TM-T16964