Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Found 257 products of "Sodium Channel"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formula:C23H20ClN3O3Color and Shape:SolidMolecular weight:421.11932Ceratotoxin-2
CAS:Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel inhibitor, demonstrating half maximal inhibitory concentrations (IC50) of 8 nM for Na v 1.2/β 1 and 88Formula:C177H260N52O49S6Purity:98%Color and Shape:SolidMolecular weight:4092.67Zoniporide
CAS:Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Formula:C17H16N6OPurity:99.74%Color and Shape:SolidMolecular weight:320.35δ-Buthitoxin-Hj1a
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, functions as a potent agonist for the NaV1.1 channel, exhibiting an EC50 value of 17 nM.Formula:C326H482N92O96S8Purity:98%Color and Shape:SolidMolecular weight:7482.39Jingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neuronsFormula:C154H219N39O45S7Purity:98%Color and Shape:SolidMolecular weight:3561.08m3-Huwentoxin IV
m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6Formula:C170H271N53O46S6Purity:98%Color and Shape:SolidMolecular weight:3985.69ω-Conotoxin CVIB
CAS:ω-Conotoxin CVIB is an antagonist of non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs).Formula:C102H173N41O32S7Purity:98%Color and Shape:SolidMolecular weight:2710.18Jingzhaotoxin-II
Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodiumFormula:C154H219N39O45S7Purity:98%Color and Shape:SolidMolecular weight:3561.081-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.Formula:C6H8N2OPurity:99.92%Color and Shape:SolidMolecular weight:124.14µ-Conotoxin KIIIA
CAS:μ-Conotoxin KIIIA, an analgesic compound derived from Conus kinoshitai, selectively inhibits mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2),Formula:C70H106N28O22S6Purity:98%Color and Shape:SolidMolecular weight:1884.16Hainantoxin-III
CAS:Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting bothFormula:C154H228N44O45S6Purity:98%Color and Shape:SolidMolecular weight:3608.125-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Formula:C13H28OPurity:97.87%Color and Shape:SolidMolecular weight:200.36APETx2
CAS:ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.Formula:C196H280N54O61S6Purity:98%Color and Shape:SolidMolecular weight:4561.06Mambalgin 1
CAS:ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Formula:C272H429N85O84S10Purity:98%Color and Shape:SolidMolecular weight:6554.51π-TRTX-Hm3a
π-TRTX-Hm3a, a 37-amino acid peptide derived from the venom of the Togo starburst tarantula (Heteroscodra maculata), selectively inhibits the acid-sensing ionFormula:C186H290N56O49S6Purity:98%Color and Shape:SolidMolecular weight:4287.03µ-Conotoxin BuIIIB
CAS:μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB), a selective blocker of mammalian neuronal voltage-gated sodium channels (VGSC), is derived from Cone snail venom andFormula:C106H172N46O30S6Purity:98%Color and Shape:SolidMolecular weight:2763.18Hm1a
Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1Formula:C170H239N47O54S6Purity:98%Color and Shape:SolidMolecular weight:3997.39ProTx II
CAS:Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.
Formula:C168H250N46O41S8Purity:98%Color and Shape:SolidMolecular weight:3826.59µ-Conotoxin-CnIIIC acetate
µ-Conotoxin-CnIIIC acetate is a NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.Formula:C92H139N35O28S6·xC2H4O2Purity:99.94%Color and Shape:SolidMolecular weight:2375.70 (free base)Dc1a
Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).Formula:C276H414N76O84S8Purity:98%Color and Shape:SolidMolecular weight:6397.22
