Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Found 257 products of "Sodium Channel"
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δ-Buthitoxin-Hj1a
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, functions as a potent agonist for the NaV1.1 channel, exhibiting an EC50 value of 17 nM.Formula:C326H482N92O96S8Purity:98%Color and Shape:SolidMolecular weight:7482.39NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formula:C23H20ClN3O3Color and Shape:SolidMolecular weight:421.11932Crotamine
Crotamine, a 42 amino acid toxin featuring three disulfide bridges, functions as a Na+ channel modulator with analgesic properties.Formula:C214H326N64O54S7Purity:98%Color and Shape:SolidMolecular weight:4883.735-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Formula:C13H28OPurity:97.87%Color and Shape:SolidMolecular weight:200.36Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
Color and Shape:Odour SolidJingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neuronsFormula:C154H219N39O45S7Purity:98%Color and Shape:SolidMolecular weight:3561.08Huwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Formula:C174H278N52O51S6Purity:98%Color and Shape:SolidMolecular weight:4106.79Batrachotoxin
CAS:Batrachotoxin (BTX), a potent neurotoxin and cardiotoxin, is found in the skin of the Colombian dart frog (Phyllobates aurotaenia). As an activator of sodium channels (sodium channel), it interferes with normal sodium channel closure by binding to voltage-gated sodium channels (sodium channel) on the cell membrane. This interaction causes a continuous influx of sodium ions into the cells, leading to persistent depolarization.Formula:C31H42N2O6Color and Shape:SolidMolecular weight:538.67δ-Buthitoxin-Hj2a
δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].Formula:C304H458N90O93S8Purity:98%Color and Shape:SolidMolecular weight:7117.96Trapencaine
CAS:Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.Formula:C22H34N2O3Purity:97.68%Color and Shape:SolidMolecular weight:374.52OD1
Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.Formula:C308H466N90O95S8Purity:98%Color and Shape:SolidMolecular weight:7206.1Zoniporide
CAS:Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Formula:C17H16N6OPurity:99.74%Color and Shape:SolidMolecular weight:320.35δ-Theraphotoxin-Hm1a toxin
δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [Formula:C170H240N48O53S6Purity:98%Color and Shape:SolidMolecular weight:3996.4Jingzhaotoxin-V
Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodiumFormula:C157H243N47O37S7Purity:98%Color and Shape:SolidMolecular weight:3605.36Phrixotoxin 3
CAS:Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.Formula:C176H269N51O48S6Purity:98%Color and Shape:SolidMolecular weight:4059.74Hainantoxin-III
CAS:Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting bothFormula:C154H228N44O45S6Purity:98%Color and Shape:SolidMolecular weight:3608.12Dc1a
Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).Formula:C276H414N76O84S8Purity:98%Color and Shape:SolidMolecular weight:6397.22Tap1a
Theraphotoxin-Tap1a (Tap1a) is a spider venom-derived peptide that acts as an inhibitor of sodium channels, displaying IC50 values of 80 nM for Na v 1.7 and 301Formula:C174H258N52O55S7Purity:98%Color and Shape:SolidMolecular weight:4182.68SLC26A3-IN-2
CAS:Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.Formula:C19H13ClN2O2SPurity:99.86%Color and Shape:SolidMolecular weight:368.84Jingzhaotoxin-II
Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodiumFormula:C154H219N39O45S7Purity:98%Color and Shape:SolidMolecular weight:3561.08
