PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Found 165 products of "PDE"
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MR-L2
CAS:<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>Formula:C19H16Cl3FN4OPurity:98.09% - 98.94%Color and Shape:SolidMolecular weight:441.71T-0156
CAS:<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>Formula:C31H29N5O7Purity:98.53% - 98.76%Color and Shape:SoildMolecular weight:583.59Milrinone
CAS:<p>Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.</p>Formula:C12H9N3OPurity:99.22% - 99.92%Color and Shape:SolidMolecular weight:211.22Cilostazol
CAS:<p>Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.</p>Formula:C20H27N5O2Purity:99.58% - 99.90%Color and Shape:Off-White SolidMolecular weight:369.46Pumafentrine
CAS:<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>Formula:C29H39N3O3Purity:>99.99%Color and Shape:SolidMolecular weight:477.64N-Methylbenzamide
CAS:<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>Formula:C8H9NOPurity:99.83%Color and Shape:Physical Description Off-White Crystalline Solid (Ntp 1992)Molecular weight:135.16Trapidil
CAS:<p>Trapidil (Avantrin) is a coronary vasodilator agent.</p>Formula:C10H15N5Purity:99.42%Color and Shape:SolidMolecular weight:205.26Pimobendan
CAS:<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Formula:C19H18N4O2Purity:99.91%Color and Shape:SolidMolecular weight:334.37Zatolmilast
CAS:<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>Formula:C21H15ClF3NO2Purity:98.20%Color and Shape:SolidMolecular weight:405.8EMD57439
CAS:<p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>Formula:C22H23N3O4SPurity:99.38% - 99.57%Color and Shape:SolidMolecular weight:425.5NSP-805
CAS:<p>NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.</p>Formula:C17H19N3O2Purity:99.85%Color and Shape:SolidMolecular weight:297.35ATX inhibitor 1
CAS:<p>ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).</p>Formula:C21H23Cl2N2O6PPurity:99.52%Color and Shape:SolidMolecular weight:501.3Roflumilast
CAS:<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>Formula:C17H14Cl2F2N2O3Purity:99.76% - 99.86%Color and Shape:SolidMolecular weight:403.21ITI-214
CAS:<p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>Formula:C29H29FN7O5PPurity:98.21%Color and Shape:SolidMolecular weight:605.56Amrinone
CAS:<p>Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.</p>Formula:C10H9N3OPurity:98.88% - 99.45%Color and Shape:SolidMolecular weight:187.2Carbodenafil
CAS:<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>Formula:C24H32N6O3Purity:98.96% - 99.89%Color and Shape:SolidMolecular weight:452.55OPC18750 HCl
CAS:<p>OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.</p>Formula:C20H23ClN2O4Purity:98.92%Color and Shape:SoildMolecular weight:390.86cis-Tadalafil
CAS:<p>Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.</p>Formula:C22H19N3O4Purity:99.89%Color and Shape:SolidMolecular weight:389.4Acetildenafil
CAS:<p>Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.</p>Formula:C25H34N6O3Color and Shape:Off-White To Pale Yelow SolidMolecular weight:466.58FCPR03
CAS:<p>FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.</p>Formula:C15H19F2NO3Purity:99.94%Color and Shape:SolidMolecular weight:299.31BC 11-38
CAS:<p>BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).</p>Formula:C15H16N2OS2Purity:98.95% - 99.28%Color and Shape:SolidMolecular weight:304.43BI 1015550
CAS:<p>Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.</p>Formula:C20H25ClN6O2SPurity:98.06% - 99.71%Color and Shape:SoildMolecular weight:448.97Arofylline
CAS:<p>Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.</p>Formula:C14H13ClN4O2Purity:98.19%Color and Shape:SolidMolecular weight:304.73Theodrenaline hydrochloride
CAS:<p>Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.</p>Formula:C17H22ClN5O5Purity:98% - 98.18%Color and Shape:SoildMolecular weight:411.84UK 227786
CAS:<p>UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.</p>Formula:C22H22Cl2N4O4Purity:99.9%Color and Shape:SoildMolecular weight:477.34(1R,2R)-MK-8189
CAS:<p>(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.</p>Formula:C19H22N6OSPurity:>99.99% - >99.99%Color and Shape:SoildMolecular weight:382.48PDE4B-IN-4
<p>PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.</p>Formula:C26H27N5O5Color and Shape:SolidMolecular weight:489.52PDE10A-IN-5
<p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>Color and Shape:Odour SolidOglemilast
CAS:<p>Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.</p>Formula:C20H13Cl2F2N3O5SPurity:99.82%Color and Shape:SolidMolecular weight:516.3ONO-8430506
CAS:<p>ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.</p>Formula:C27H28FN3O3Purity:98.34%Color and Shape:SolidMolecular weight:461.53Enpp-1-IN-14
CAS:<p>Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.</p>Formula:C15H22ClN5O4SPurity:99.83%Color and Shape:SoildMolecular weight:403.88WAY-313170
CAS:<p>WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.</p>Formula:C19H17ClN2O2S2Purity:99.3%Color and Shape:SolidMolecular weight:404.93PDE5-IN-9
CAS:<p>WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.</p>Formula:C18H14N4SPurity:99.98%Color and Shape:SolidMolecular weight:318.4Dazonone
CAS:<p>Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.</p>Formula:C11H10ClN3OPurity:99.54% - 99.73%Color and Shape:SolidMolecular weight:235.67BAY 2666605
CAS:<p>BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.</p>Formula:C17H12F4N2O2Purity:99.81%Color and Shape:SolidMolecular weight:352.28ALDH7A1 Protein, Human, Recombinant (His)
<p>ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.</p>Color and Shape:Lyophilized PowderMolecular weight:56 kDa (predicted); 56 kDa (reducing conditions)PF-05085727
CAS:<p>PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.</p>Formula:C20H18F3N7Purity:98%Color and Shape:SolidMolecular weight:413.4Autotaxin modulator 1
CAS:<p>Autotaxin modulator 1 is a new modulator of Autotaxin.</p>Formula:C28H31F6NO3Purity:99.46%Color and Shape:SolidMolecular weight:543.54N-Ethyl tadalafil
CAS:<p>N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.</p>Formula:C23H21N3O4Purity:99.58%Color and Shape:SolidMolecular weight:403.43Anti-ALDH7A1 Antibody (1G435)
<p>Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.</p>Color and Shape:Odour LiquidBay 60-7550
CAS:<p>Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.</p>Formula:C27H32N4O4Purity:98.14%Color and Shape:SolidMolecular weight:476.57PF-05180999
CAS:<p>α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.</p>Formula:C19H17F3N8Purity:99.43% - 99.82%Color and Shape:SolidMolecular weight:414.39Anti-ALDH7A1 Antibody (6G475)
<p>Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.</p>Color and Shape:Odour LiquidAnti-ALDH7A1 Antibody-FITC (5P692)
<p>Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-ALDH7A1 Antibody (3P955)
<p>Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.</p>Color and Shape:Odour LiquidAnti-ALDH7A1 Antibody (5P692)
<p>Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.</p>Color and Shape:Odour LiquidENPP1 Inhibitor C
CAS:<p>ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.</p>Formula:C15H18N6Purity:99.28%Color and Shape:SolidMolecular weight:282.34BAY 73-6691 racemate
CAS:<p>BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.</p>Formula:C15H12ClF3N4OColor and Shape:SolidMolecular weight:356.73D159687
CAS:<p>D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.</p>Formula:C21H19ClN2O2Purity:97.57%Color and Shape:SolidMolecular weight:366.84HA 155
CAS:<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Formula:C24H19BFNO5SPurity:99.88%Color and Shape:SolidMolecular weight:463.29
