PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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PDE5-IN-2
CAS:2244517-61-9
PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
Formula:
C25H21N3O6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
491.52
Ref: TM-T12394
| 25mg | 1,827.00 € | ||
| 50mg | 2,404.00 € | ||
| 100mg | 3,168.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Adibendan
CAS:100510-33-6
Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.
Formula:
C16H14N4O
Purity:
100% - 99.61%
Color and Shape:
Solid
Molecular weight:
278.31
Ref: TM-T23638
| 1mg | 113.00 € | ||
| 2mg | 169.00 € | ||
| 5mg | 251.00 € | ||
| 10mg | 368.00 € | ||
| 25mg | 551.00 € | ||
| 50mg | 776.00 € | ||
| 100mg | 1,043.00 € | ||
| 500mg | To inquire | ||
| 1mL*10mM (DMSO) | 239.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Difamilast
CAS:937782-05-3
Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B …
Formula:
C23H24F2N2O5
Purity:
99.04%
Color and Shape:
Solid
Molecular weight:
446.44
Ref: TM-T27172
| 1mg | 67.00 € | ||
| 5mg | 144.00 € | ||
| 10mg | 226.00 € | ||
| 25mg | 451.00 € | ||
| 50mg | 725.00 € | ||
| 100mg | 1,171.00 € | ||
| 1mL*10mM (DMSO) | 158.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
BIO-32546
CAS:1548743-66-3
BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of …
Formula:
C28H31F6NO3
Purity:
98.03%
Color and Shape:
Solid
Molecular weight:
543.54
Ref: TM-T10545
| 1mg | 214.00 € | ||
| 5mg | 530.00 € | ||
| 10mg | 873.00 € | ||
| 25mg | 1,822.00 € | ||
| 50mg | 2,920.00 € | ||
| 100mg | 4,696.00 € | ||
| 1mL*10mM (DMSO) | 36.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Siguazodan
CAS:115344-47-3
Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an …
Formula:
C14H16N6O
Purity:
99.63% - 99.77%
Color and Shape:
Solid
Molecular weight:
284.32
Ref: TM-T12913
| 1mg | 42.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 126.00 € | ||
| 25mg | 261.00 € | ||
| 50mg | 419.00 € | ||
| 100mg | 647.00 € | ||
| 200mg | 913.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
TPN171
CAS:1229018-87-4
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, …
Formula:
C24H35N5O3
Purity:
100%
Color and Shape:
Solid
Molecular weight:
441.57
Ref: TM-T13193
| 1mg | 128.00 € | ||
| 5mg | 313.00 € | ||
| 10mg | 453.00 € | ||
| 25mg | 686.00 € | ||
| 50mg | 911.00 € | ||
| 100mg | 1,254.00 € | ||
| 500mg | 2,516.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Autotaxin-IN-5
CAS:2156655-99-9
Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
Formula:
C30H29N9O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
547.61
Ref: TM-T10417
| 25mg | 1,967.00 € | ||
| 50mg | 2,600.00 € | ||
| 100mg | 3,460.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
GSK356278
CAS:720704-34-7
GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.
Formula:
C21H25N7O2S
Purity:
90% - 99.43%
Color and Shape:
Solid
Molecular weight:
439.53
Ref: TM-T27475
| 2mg | 40.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 167.00 € | ||
| 50mg | 301.00 € | ||
| 100mg | 478.00 € | ||
| 200mg | 648.00 € | ||
| 500mg | 1,012.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
AMG 579
CAS:1227067-61-9
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
Formula:
C25H23N5O3
Purity:
99.35%
Color and Shape:
Solid
Molecular weight:
441.48
Ref: TM-T14217
| 1mg | 35.00 € | ||
| 2mg | 46.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 103.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
PF-04957325
CAS:1305115-80-3
PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can …
Formula:
C14H15F3N8OS
Purity:
99.02%
Color and Shape:
Solid
Molecular weight:
400.38
Ref: TM-T12422
| 1mg | 136.00 € | ||
| 5mg | 229.00 € | ||
| 10mg | 345.00 € | ||
| 25mg | 596.00 € | ||
| 50mg | 864.00 € | ||
| 100mg | 1,289.00 € | ||
| 1mL*10mM (DMSO) | 205.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
TP-10
CAS:898563-00-3
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
Formula:
C26H19F3N4O
Purity:
98.48%
Color and Shape:
Solid
Molecular weight:
460.45
Ref: TM-T13189
| 1mg | 92.00 € | ||
| 2mg | 120.00 € | ||
| 5mg | 185.00 € | ||
| 10mg | 274.00 € | ||
| 25mg | 476.00 € | ||
| 50mg | 695.00 € | ||
| 100mg | 976.00 € | ||
| 500mg | 1,867.00 € | ||
| 1mL*10mM (DMSO) | 187.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Cudetaxestat
CAS:1782070-21-6
Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.
Formula:
C21H15Cl2F2N3O2S
Purity:
98.84%
Color and Shape:
Liquid
Molecular weight:
482.33
Ref: TM-T63190
| 1mg | 75.00 € | ||
| 5mg | 166.00 € | ||
| 10mg | 241.00 € | ||
| 25mg | 432.00 € | ||
| 50mg | 643.00 € | ||
| 100mg | 904.00 € | ||
| 200mg | 1,192.00 € | ||
| 1mL*10mM (DMSO) | 171.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
PDE9-IN-(S)-C33
CAS:2066488-39-7
PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.
Formula:
C18H20ClN5O
Purity:
98.75%
Color and Shape:
Solid
Molecular weight:
357.84
Ref: TM-T28352
| 1mg | 60.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 155.00 € | ||
| 25mg | 243.00 € | ||
| 50mg | 360.00 € | ||
| 100mg | 536.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Autotaxin-IN-4
CAS:2156655-86-4
Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
Formula:
C22H21N9O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
443.46
Ref: TM-T10416
| 25mg | 1,688.00 € | ||
| 50mg | 2,217.00 € | ||
| 100mg | 2,888.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Tovinontrine
CAS:2062661-53-2
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target …
Formula:
C21H26N6O2
Purity:
98.14%
Color and Shape:
Liquid
Molecular weight:
394.47
Ref: TM-T61833
| 1mg | 102.00 € | ||
| 5mg | 244.00 € | ||
| 10mg | 351.00 € | ||
| 25mg | 568.00 € | ||
| 50mg | 759.00 € | ||
| 1mL*10mM (DMSO) | 268.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
Thioquinapiperifil dihydrochloride
CAS:204077-66-7
Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.
Formula:
C24H29ClN6OS
Purity:
98.73%
Color and Shape:
Solid
Molecular weight:
485.05
Ref: TM-T9773
| 1mg | 121.00 € | ||
| 5mg | 291.00 € | ||
| 10mg | 436.00 € | ||
| 25mg | 707.00 € | ||
| 50mg | 916.00 € | ||
| 100mg | 1,281.00 € | ||
| 1mL*10mM (DMSO) | 333.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
PF-00489791
CAS:853003-48-2
PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic …
Formula:
C20H28N8O4S
Purity:
100%
Color and Shape:
Solid
Molecular weight:
476.55
Ref: TM-T28360
| 1mg | 102.00 € | ||
| 5mg | 213.00 € | ||
| 10mg | 323.00 € | ||
| 25mg | 537.00 € | ||
| 50mg | 767.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
