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PDE

PDE

Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.

Found 165 products of "PDE"

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  • Gisadenafil
    Targetmol
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    Gisadenafil

    CAS:
    <p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>
    Formula:C23H33N7O5S
    Purity:98.82% - 99.50%
    Color and Shape:Solid
    Molecular weight:519.62

    Ref: TM-T15381

  • PDE5-IN-2
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    PDE5-IN-2

    CAS:
    <p>PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)</p>
    Formula:C25H21N3O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:491.52

    Ref: TM-T12394

  • CI-1044
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    CI-1044

    CAS:
    <p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>
    Formula:C23H19N5O2
    Color and Shape:Solid
    Molecular weight:397.43

    Ref: TM-T14962

  • BIO-32546
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    BIO-32546

    CAS:
    <p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>
    Formula:C28H31F6NO3
    Purity:98.03%
    Color and Shape:Solid
    Molecular weight:543.54

    Ref: TM-T10545

  • Gisadenafil besylate
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    Gisadenafil besylate

    CAS:
    <p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>
    Formula:C29H39N7O8S2
    Color and Shape:Solid
    Molecular weight:677.79

    Ref: TM-T11400

  • Difamilast
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    Difamilast

    CAS:
    <p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>
    Formula:C23H24F2N2O5
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:446.44

    Ref: TM-T27172

  • Siguazodan
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    Siguazodan

    CAS:
    <p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>
    Formula:C14H16N6O
    Purity:99.62% - 99.87%
    Color and Shape:Solid
    Molecular weight:284.32

    Ref: TM-T12913

  • Adibendan
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    Adibendan

    CAS:
    <p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>
    Formula:C16H14N4O
    Purity:99.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:278.31

    Ref: TM-T23638

  • Autotaxin-IN-4
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    Autotaxin-IN-4

    CAS:
    <p>Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>
    Formula:C22H21N9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:443.46

    Ref: TM-T10416

  • PF-04957325
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    PF-04957325

    CAS:
    <p>PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.</p>
    Formula:C14H15F3N8OS
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:400.38

    Ref: TM-T12422

  • PDE9-IN-(S)-C33
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    PDE9-IN-(S)-C33

    CAS:
    <p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>
    Formula:C18H20ClN5O
    Purity:98.75%
    Color and Shape:Solid
    Molecular weight:357.84

    Ref: TM-T28352

  • Enpp-1-IN-16
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    Enpp-1-IN-16

    CAS:
    <p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>
    Formula:C23H32N4O4
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:428.52

    Ref: TM-T78169

  • TPN171
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    TPN171

    CAS:
    <p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>
    Formula:C24H35N5O3
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:441.57

    Ref: TM-T13193

  • AMG 579
    Targetmol
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    AMG 579

    CAS:
    <p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>
    Formula:C25H23N5O3
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:441.48

    Ref: TM-T14217

  • Cudetaxestat
    Targetmol
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    Cudetaxestat

    CAS:
    <p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>
    Formula:C21H15Cl2F2N3O2S
    Purity:99.9%
    Color and Shape:Solid
    Molecular weight:482.33

    Ref: TM-T63190

  • TP-10
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    TP-10

    CAS:
    <p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>
    Formula:C26H19F3N4O
    Purity:99.21%
    Color and Shape:Solid
    Molecular weight:460.45

    Ref: TM-T13189

  • Thioquinapiperifil dihydrochloride
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    Thioquinapiperifil dihydrochloride

    CAS:
    <p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>
    Formula:C24H29ClN6OS
    Purity:98.73%
    Color and Shape:Solid
    Molecular weight:485.05

    Ref: TM-T9773

  • PF-00489791
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    PF-00489791

    CAS:
    <p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>
    Formula:C20H28N8O4S
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:476.55

    Ref: TM-T28360

  • Deltasonamide 2 hydrochloride
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    Deltasonamide 2 hydrochloride

    <p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>
    Formula:C30H40Cl2N6O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:683.71

    Ref: TM-T10994L

  • ASP9831
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    ASP9831

    CAS:
    <p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>
    Formula:C20H23N3O3
    Color and Shape:Solid
    Molecular weight:353.42

    Ref: TM-T207494