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PDE

PDE

Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.

Found 165 products of "PDE"

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  • PDE IV-IN-1
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    PDE IV-IN-1

    CAS:
    <p>PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease</p>
    Formula:C20H23ClN4O2
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:386.88

    Ref: TM-T10201

  • Tanimilast
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    Tanimilast

    CAS:
    <p>Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.</p>
    Formula:C30H30Cl2F2N2O8S
    Purity:98.34%
    Color and Shape:Solid
    Molecular weight:687.54

    Ref: TM-T38625

  • uk-50001
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    uk-50001

    CAS:
    <p>UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.</p>
    Formula:C26H24F3N3O4
    Purity:99.90%
    Color and Shape:Solid
    Molecular weight:499.48

    Ref: TM-T67815

  • PDE4B-IN-2
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    PDE4B-IN-2

    CAS:
    <p>PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.</p>
    Formula:C19H18ClN3O2S
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:387.88

    Ref: TM-T36832

  • Nanterinone
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    Nanterinone

    CAS:
    <p>Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.</p>
    Formula:C15H15N3O
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:253.3

    Ref: TM-T33589

  • Dovramilast
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    Dovramilast

    CAS:
    <p>Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.</p>
    Formula:C24H28N2O6S
    Purity:98.75% - 99.62%
    Color and Shape:Solid
    Molecular weight:472.55

    Ref: TM-T63056

  • Verofylline
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    Verofylline

    CAS:
    <p>Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the</p>
    Formula:C12H18N4O2
    Purity:98.33% - 98.83%
    Color and Shape:Solid
    Molecular weight:250.3

    Ref: TM-T35048

  • Carbazeran
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    Carbazeran

    CAS:
    <p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>
    Formula:C18H24N4O4
    Purity:99.3%
    Color and Shape:Solid
    Molecular weight:360.41

    Ref: TM-T21457

  • AWD 12-281
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    AWD 12-281

    CAS:
    <p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>
    Formula:C22H14Cl2FN3O3
    Purity:99.25% - 99.85%
    Color and Shape:Solid
    Molecular weight:458.27

    Ref: TM-T30232

  • Autotaxin-IN-3
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    Autotaxin-IN-3

    CAS:
    <p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>
    Formula:C22H21N9O2
    Purity:99.54% - 99.79%
    Color and Shape:Solid
    Molecular weight:443.46

    Ref: TM-T10415

  • Filaminast
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    Filaminast

    CAS:
    <p>Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.</p>
    Formula:C15H20N2O4
    Purity:98.53% - 98.93%
    Color and Shape:Solid
    Molecular weight:292.33

    Ref: TM-T31792

  • MK-0873
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    MK-0873

    CAS:
    <p>MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.</p>
    Formula:C25H18N4O3
    Purity:98.40%
    Color and Shape:Solid
    Molecular weight:422.44

    Ref: TM-T33422

  • Mopidamol
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    Mopidamol

    CAS:
    <p>Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental</p>
    Formula:C19H31N7O4
    Purity:99.05% - 99.78%
    Color and Shape:Solid
    Molecular weight:421.49

    Ref: TM-T25829

  • Isomazole
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    Isomazole

    CAS:
    <p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>
    Formula:C14H13N3O2S
    Purity:98.66%
    Color and Shape:Solid
    Molecular weight:287.34

    Ref: TM-T27632

  • Tofimilast
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    Tofimilast

    CAS:
    <p>Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.</p>
    Formula:C18H21N5S
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:339.46

    Ref: TM-T28991

  • Dasantafil
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    Dasantafil

    CAS:
    <p>Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.</p>
    Formula:C22H28BrN5O5
    Purity:99.4% - 99.50%
    Color and Shape:Solid
    Molecular weight:522.39

    Ref: TM-T27122

  • PF-04447943
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    PF-04447943

    CAS:
    <p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>
    Formula:C20H25N7O2
    Purity:99.36% - 99.59%
    Color and Shape:Solid
    Molecular weight:395.46

    Ref: TM-T16478

  • GSK356278
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    GSK356278

    CAS:
    <p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>
    Formula:C21H25N7O2S
    Purity:99.90% - 99.97%
    Color and Shape:Solid
    Molecular weight:439.53

    Ref: TM-T27475

  • MK-8189
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    MK-8189

    CAS:
    <p>MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.</p>
    Formula:C19H22N6OS
    Purity:99.38% - 99.67%
    Color and Shape:Solid
    Molecular weight:382.48

    Ref: TM-T73462

  • Autotaxin-IN-5
    Targetmol
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    Autotaxin-IN-5

    CAS:
    <p>Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>
    Formula:C30H29N9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:547.61

    Ref: TM-T10417