PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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Propentofylline
CAS:55242-55-2
Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study …
Formula:
C15H22N4O3
Purity:
99.11% - 99.42%
Color and Shape:
Off-White Solid
Molecular weight:
306.36
Ref: TM-T19812
| 1mg | 69.00 € | ||
| 5mg | 145.00 € | ||
| 10mg | 212.00 € | ||
| 25mg | 358.00 € | ||
| 50mg | 527.00 € | ||
| 100mg | 750.00 € | ||
| 1mL*10mM (DMSO) | 157.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Autotaxin-IN-3
CAS:2156655-68-2
Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the …
Formula:
C22H21N9O2
Purity:
98.49% - 99.21%
Color and Shape:
Solid
Molecular weight:
443.46
Ref: TM-T10415
| 2mg | 46.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 101.00 € | ||
| 25mg | 183.00 € | ||
| 50mg | 284.00 € | ||
| 100mg | 455.00 € | ||
| 200mg | 625.00 € | ||
| 1mL*10mM (DMSO) | 78.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Filaminast
CAS:141184-34-1
Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which …
Formula:
C15H20N2O4
Purity:
98.44% - 99.64%
Color and Shape:
Solid
Molecular weight:
292.33
Ref: TM-T31792
| 1mg | 226.00 € | ||
| 5mg | 552.00 € | ||
| 10mg | 735.00 € | ||
| 25mg | 1,111.00 € | ||
| 50mg | 1,491.00 € | ||
| 100mg | 2,005.00 € | ||
| 200mg | 2,707.00 € | ||
| 1mL*10mM (DMSO) | 500.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
AWD 12-281
CAS:257892-33-4
AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study …
Formula:
C22H14Cl2FN3O3
Purity:
99.55% - 99.95%
Color and Shape:
Solid
Molecular weight:
458.27
Ref: TM-T30232
| 1mg | 279.00 € | ||
| 5mg | 685.00 € | ||
| 10mg | 938.00 € | ||
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Mopidamol
CAS:13665-88-8
Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents …
Formula:
C19H31N7O4
Purity:
99.42% - 99.51%
Color and Shape:
Solid
Molecular weight:
421.49
Ref: TM-T25829
| 1mg | 361.00 € | ||
| 5mg | 845.00 € | ||
| 10mg | 1,169.00 € | ||
| 25mg | 1,738.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
MK-0873
CAS:500355-52-2
MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.
Formula:
C25H18N4O3
Purity:
99.29%
Color and Shape:
Solid
Molecular weight:
422.44
Ref: TM-T33422
| 1mg | 96.00 € | ||
| 5mg | 200.00 € | ||
| 10mg | 303.00 € | ||
| 25mg | 490.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
PDE9-IN-1
CAS:2305087-92-5
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).
Formula:
C17H23FN6O2
Purity:
100%
Color and Shape:
Solid
Molecular weight:
362.4
Ref: TM-T12395
| 1mg | 57.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 188.00 € | ||
| 25mg | 335.00 € | ||
| 50mg | 490.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
PF-04822163
CAS:1798334-07-2
PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.
Formula:
C19H17ClN2O2
Purity:
100%
Color and Shape:
Solid
Molecular weight:
340.8
Ref: TM-T28367
| 1mg | 333.00 € | ||
| 5mg | 787.00 € | ||
| 50mg | 1,882.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Dasantafil
CAS:569351-91-3
Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and …
Formula:
C22H28BrN5O5
Purity:
98.64% - 99.16%
Color and Shape:
Solid
Molecular weight:
522.39
Ref: TM-T27122
| 2mg | 34.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
TyK2-IN-2
CAS:2098466-94-3
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM …
Formula:
C16H18N6O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
310.35
Ref: TM-T13232
| 5mg | 424.00 € | ||
| 25mg | 1,415.00 € | ||
| 50mg | 1,843.00 € | ||
| 100mg | 2,642.00 € | ||
| 1mL*10mM (DMSO) | 306.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Tofimilast
CAS:185954-27-2
Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic …
Formula:
C18H21N5S
Purity:
99.94%
Color and Shape:
Solid
Molecular weight:
339.46
Ref: TM-T28991
| 1mg | 96.00 € | ||
| 5mg | 200.00 € | ||
| 10mg | 303.00 € | ||
| 25mg | 490.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Naproxen etemesil
CAS:385800-16-8
Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic …
Formula:
C17H20O5S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
336.4
Ref: TM-T16272
| 25mg | 812.00 € | ||
| 50mg | 1,054.00 € | ||
| 100mg | 1,529.00 € | ||
| 1mL*10mM (DMSO) | 246.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
AN3199
CAS:1187187-10-5
AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
Formula:
C17H18BNO5
Purity:
100%
Color and Shape:
Solid
Molecular weight:
327.14
Ref: TM-T10316
| 10mg | 46.00 € | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 27 Jun 2025
Senazodan hydrochloride
CAS:98326-33-1
Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in …
Formula:
C15H15ClN4O
Purity:
99.93%
Color and Shape:
Solid
Molecular weight:
302.76
Ref: TM-T28752
| 1mg | 99.00 € | ||
| 5mg | 235.00 € | ||
| 10mg | 376.00 € | ||
| 25mg | 747.00 € | ||
| 50mg | 1,121.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Autotaxin-IN-1
CAS:1619971-30-0
Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.
Formula:
C21H23N7O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
405.45
Ref: TM-T14352
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
BAY 73-6691
CAS:794568-92-6
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
Formula:
C15H12ClF3N4O
Color and Shape:
Solid
Molecular weight:
356.73
Ref: TM-T10481L
| 25mg | 655.00 € | ||
| 50mg | 852.00 € | ||
| 100mg | 1,415.00 € | ||
| 1mL*10mM (DMSO) | 187.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Deltasonamide 2 (TFA)
CAS:2235358-74-2
Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
Formula:
C32H40ClF3N6O6S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
761.28
Ref: TM-T10994L2
| 25mg | 938.00 € | ||
| 50mg | 1,293.00 € | ||
| 100mg | 2,080.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
Tanimilast
CAS:1239278-59-1
Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for …
Formula:
C30H30Cl2F2N2O8S
Purity:
98.3%
Color and Shape:
Solid
Molecular weight:
687.54
Ref: TM-T38625
| 1mg | 221.00 € | ||
| 5mg | 550.00 € | ||
| 10mg | 825.00 € | ||
| 25mg | 1,388.00 € | ||
| 50mg | 1,872.00 € | ||
| 100mg | 2,517.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
uk-50001
CAS:857900-47-1
UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.
Formula:
C26H24F3N3O4
Purity:
99.90%
Color and Shape:
Liquid
Molecular weight:
499.48
Ref: TM-T67815
| 1mg | 159.00 € | ||
| 5mg | 380.00 € | ||
| 10mg | 570.00 € | ||
| 25mg | 912.00 € | ||
| 50mg | 1,216.00 € | ||
| 100mg | 1,663.00 € | ||
| 500mg | 3,315.00 € | ||
| 1mL*10mM (DMSO) | 470.00 € |
Estimated delivery in United States, on Friday 27 Jun 2025
AMG 579
CAS:1227067-61-9
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
Formula:
C25H23N5O3
Purity:
99.35%
Color and Shape:
Solid
Molecular weight:
441.48
Ref: TM-T14217
| 1mg | 35.00 € | ||
| 2mg | 47.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 105.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
