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PDE

PDE

Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.

Found 165 products of "PDE"

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  • Tovinontrine
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    Tovinontrine

    CAS:
    <p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>
    Formula:C21H26N6O2
    Purity:98.14%
    Color and Shape:Solid
    Molecular weight:394.47

    Ref: TM-T61833

  • BMS-341400 mesylate
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    BMS-341400 mesylate

    CAS:
    <p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>
    Formula:C24H26ClN9O5S
    Color and Shape:Solid
    Molecular weight:588.039

    Ref: TM-T204188

  • TAK-915
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    TAK-915

    CAS:
    <p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>
    Formula:C19H18F4N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:458.36

    Ref: TM-T16976

  • Z21090
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    Z21090

    CAS:
    <p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>
    Formula:C12H14ClN3O3
    Color and Shape:Solid
    Molecular weight:283.71

    Ref: TM-T87655

  • NHTD
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    NHTD

    CAS:
    <p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>
    Formula:C24H26N2O5
    Color and Shape:Solid
    Molecular weight:422.47

    Ref: TM-T200095