PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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BAY 2666605
CAS:2275774-60-0
BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 …
Formula:
C17H12F4N2O2
Purity:
99.98%
Color and Shape:
Liquid
Molecular weight:
352.28
Ref: TM-T9805
| 1mg | 97.00 € | ||
| 5mg | 235.00 € | ||
| 10mg | 376.00 € | ||
| 25mg | 827.00 € | ||
| 50mg | 1,319.00 € | ||
| 100mg | 2,115.00 € | ||
| 1mL*10mM (DMSO) | 258.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Dazonone
CAS:105622-85-3
Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.
Formula:
C11H10ClN3O
Purity:
99.21% - 99.67%
Color and Shape:
Liquid
Molecular weight:
235.67
Ref: TM-T9871
| 1mg | 113.00 € | ||
| 2mg | 169.00 € | ||
| 5mg | 250.00 € | ||
| 10mg | 367.00 € | ||
| 25mg | 550.00 € | ||
| 50mg | 775.00 € | ||
| 100mg | 1,040.00 € | ||
| 500mg | 2,098.00 € | ||
| 1mL*10mM (DMSO) | 221.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Nauclefine
CAS:57103-51-2
Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.
Formula:
C18H13N3O
Purity:
99.92%
Color and Shape:
Solid
Molecular weight:
287.32
Ref: TM-TN6120
| 1mg | 114.00 € | ||
| 2mg | 172.00 € | ||
| 5mg | 250.00 € | ||
| 10mg | 368.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
Vardenafil dihydrochloride
CAS:224789-15-5
Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 …
Formula:
C23H34Cl2N6O4S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
561.52
Ref: TM-T4480
| 25mg | 51.00 € | ||
| 50mg | 92.00 € | ||
| 100mg | 150.00 € | ||
| 200mg | 255.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
WAY-313170
CAS:314041-83-3
WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.
Formula:
C19H17ClN2O2S2
Purity:
99.3%
Color and Shape:
Solid
Molecular weight:
404.93
Ref: TM-T77603
| 1mg | 73.00 € | ||
| 5mg | 158.00 € | ||
| 10mg | 241.00 € | ||
| 25mg | 486.00 € | ||
| 50mg | 705.00 € | ||
| 100mg | 984.00 € | ||
| 500mg | 1,990.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Oglemilast
CAS:778576-62-8
Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in …
Formula:
C20H13Cl2F2N3O5S
Purity:
98.11%
Color and Shape:
Solid
Molecular weight:
516.3
Ref: TM-T16379
| 1mg | 42.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 146.00 € | ||
| 25mg | 216.00 € | ||
| 50mg | 277.00 € | ||
| 100mg | 403.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Arofylline
CAS:136145-07-8
Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.
Formula:
C14H13ClN4O2
Purity:
97.98%
Color and Shape:
Liquid
Molecular weight:
304.73
Ref: TM-T9816
| 1mg | 181.00 € | ||
| 5mg | 409.00 € | ||
| 10mg | 602.00 € | ||
| 25mg | 918.00 € | ||
| 50mg | 1,283.00 € | ||
| 1mL*10mM (DMSO) | 407.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
EMD57439
CAS:148714-88-9
EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing …
Formula:
C22H23N3O4S
Purity:
98% - 99.38%
Color and Shape:
Solid
Molecular weight:
425.5
Ref: TM-T25373
| 1mg | 183.00 € | ||
| 5mg | 435.00 € | ||
| 10mg | 635.00 € | ||
| 25mg | 1,000.00 € | ||
| 50mg | 1,336.00 € | ||
| 100mg | 1,803.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
OPC18750 HCl
CAS:145364-90-5
OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to …
Formula:
C20H23ClN2O4
Purity:
98.92%
Color and Shape:
Soild
Molecular weight:
390.86
Ref: TM-T83974
| 1mg | 185.00 € | ||
| 5mg | 458.00 € | ||
| 10mg | 657.00 € | ||
| 25mg | 1,025.00 € | ||
| 50mg | 1,413.00 € | ||
| 100mg | 1,868.00 € | ||
| 1mL*10mM (DMSO) | 46.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
BI 1015550
CAS:1423719-30-5
Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and …
Formula:
C20H25ClN6O2S
Purity:
100% - 99.71%
Color and Shape:
Soild
Molecular weight:
448.97
Ref: TM-T72031
| 1mg | 64.00 € | ||
| 5mg | 122.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 369.00 € | ||
| 50mg | 547.00 € | ||
| 100mg | 783.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
FCPR03
CAS:1917347-65-9
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 …
Formula:
C15H19F2NO3
Purity:
100.00%
Color and Shape:
Solid
Molecular weight:
299.31
Ref: TM-T39341
| 1mg | 51.00 € | ||
| 2mg | 73.00 € | ||
| 5mg | 112.00 € | ||
| 10mg | 177.00 € | ||
| 25mg | 301.00 € | ||
| 50mg | 428.00 € | ||
| 100mg | 583.00 € | ||
| 200mg | 785.00 € | ||
| 1mL*10mM (DMSO) | 124.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
TAK-915
CAS:1476727-50-0
TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.
Formula:
C19H18F4N4O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
458.36
Ref: TM-T16976
| 5mg | 721.00 € | ||
| 10mg | 1,152.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
BC 11-38
CAS:686770-80-9
BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 …
Formula:
C15H16N2OS2
Purity:
97.71% - 98.72%
Color and Shape:
Solid
Molecular weight:
304.43
Ref: TM-T21865
| 2mg | 46.00 € | ||
| 5mg | 71.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 202.00 € | ||
| 50mg | 330.00 € | ||
| 100mg | 527.00 € | ||
| 200mg | 747.00 € | ||
| 500mg | 1,099.00 € | ||
| 1mL*10mM (DMSO) | 91.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
cis-Tadalafil
CAS:171596-27-3
Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.
Formula:
C22H19N3O4
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
389.4
Ref: TM-T20024
| 1mg | 277.00 € | ||
| 5mg | 682.00 € | ||
| 10mg | 932.00 € | ||
| 25mg | 1,435.00 € | ||
| 50mg | 1,869.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
ONO-8430506
CAS:1354805-08-5
ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX …
Formula:
C27H28FN3O3
Purity:
97.05%
Color and Shape:
Liquid
Molecular weight:
461.53
Ref: TM-T38759
| 1mg | 245.00 € | ||
| 5mg | 600.00 € | ||
| 10mg | 830.00 € | ||
| 25mg | 1,256.00 € | ||
| 50mg | 1,693.00 € | ||
| 100mg | 2,278.00 € | ||
| 1mL*10mM (DMSO) | 676.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
ENPP1 Inhibitor C
CAS:2378640-92-5
ENPP1 Inhibitor C is an ENPP1 inhibitor with potential anticancer activity for the study of …
Formula:
C15H18N6
Color and Shape:
Liquid
Molecular weight:
282.34
Ref: TM-T37431
| Undefined size | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
Enpp/Carbonic anhydrase-IN-1
CAS:2883495-35-8
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.
Formula:
C23H25NO4S
Purity:
100%
Color and Shape:
Soild
Molecular weight:
411.51
Ref: TM-T67775
| 5mg | 44.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 114.00 € | ||
| 50mg | 182.00 € | ||
| 100mg | 299.00 € | ||
| 200mg | 422.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Autotaxin modulator 1
CAS:1548743-69-6
Autotaxin modulator 1 is a new modulator of Autotaxin.
Formula:
C28H31F6NO3
Color and Shape:
Solid
Molecular weight:
543.54
Ref: TM-T10418
| 2mg | 89.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
PF-05085727
CAS:1415637-72-7
PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.
Formula:
C20H18F3N7
Purity:
98%
Color and Shape:
Solid
Molecular weight:
413.4
Ref: TM-T16482
| 2mg | 88.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Zardaverine
CAS:101975-10-4
Zardaverine (BY 290) is a PDE3/4 inhibitor with anti-hepatocarcinogenic activity and is used in the …
Formula:
C12H10F2N2O3
Purity:
99.11%
Color and Shape:
Solid
Molecular weight:
268.22
Ref: TM-T17284
| 5mg | 96.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
