PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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PF-04447943
CAS:1082744-20-4
PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory …
Formula:
C20H25N7O2
Purity:
99.11% - 99.11%
Color and Shape:
Solid
Molecular weight:
395.46
Ref: TM-T16478
| 1mg | 35.00 € | ||
| 5mg | 81.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 188.00 € | ||
| 50mg | 283.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
AMG 579
CAS:1227067-61-9
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
Formula:
C25H23N5O3
Purity:
99.35%
Color and Shape:
Solid
Molecular weight:
441.48
Ref: TM-T14217
| 1mg | 35.00 € | ||
| 2mg | 47.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 105.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Sulmazole
CAS:73384-60-8
Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is …
Formula:
C14H13N3O2S
Purity:
99.64%
Color and Shape:
Solid
Molecular weight:
287.34
Ref: TM-T28881
| 1mg | 38.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 170.00 € | ||
| 50mg | 253.00 € | ||
| 100mg | 378.00 € | ||
| 500mg | 898.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Gisadenafil
CAS:334826-98-1
Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 …
Formula:
C23H33N7O5S
Purity:
98.25% - 99.06%
Color and Shape:
Solid
Molecular weight:
519.62
Ref: TM-T15381
| 1mg | 185.00 € | ||
| 5mg | 415.00 € | ||
| 10mg | 613.00 € | ||
| 25mg | 938.00 € | ||
| 50mg | 1,311.00 € | ||
| 100mg | 1,768.00 € | ||
| 1mL*10mM (DMSO) | 520.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Enpp-1-IN-16
CAS:2289739-47-3
Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance …
Formula:
C23H32N4O4
Purity:
98.74%
Color and Shape:
Liquid
Molecular weight:
428.52
Ref: TM-T78169
| 2mg | 54.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 126.00 € | ||
| 25mg | 274.00 € | ||
| 50mg | 432.00 € | ||
| 100mg | 683.00 € | ||
| 500mg | 1,415.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
PDE5-IN-2
CAS:2244517-61-9
PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
Formula:
C25H21N3O6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
491.52
Ref: TM-T12394
| 25mg | 1,872.00 € | ||
| 50mg | 2,452.00 € | ||
| 100mg | 3,230.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
CI-1044
CAS:197894-84-1
CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, …
Formula:
C23H19N5O2
Color and Shape:
Solid
Molecular weight:
397.43
Ref: TM-T14962
| 5mg | 283.00 € | ||
| 25mg | 938.00 € | ||
| 50mg | 1,293.00 € | ||
| 100mg | 1,768.00 € | ||
| 1mL*10mM (DMSO) | 303.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Difamilast
CAS:937782-05-3
Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B …
Formula:
C23H24F2N2O5
Purity:
99.04%
Color and Shape:
Solid
Molecular weight:
446.44
Ref: TM-T27172
| 1mg | 69.00 € | ||
| 5mg | 149.00 € | ||
| 10mg | 235.00 € | ||
| 25mg | 469.00 € | ||
| 50mg | 753.00 € | ||
| 100mg | 1,216.00 € | ||
| 1mL*10mM (DMSO) | 164.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Adibendan
CAS:100510-33-6
Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.
Formula:
C16H14N4O
Purity:
100% - 99.61%
Color and Shape:
Solid
Molecular weight:
278.31
Ref: TM-T23638
| 1mg | 115.00 € | ||
| 2mg | 172.00 € | ||
| 5mg | 255.00 € | ||
| 10mg | 375.00 € | ||
| 25mg | 562.00 € | ||
| 50mg | 792.00 € | ||
| 100mg | 1,064.00 € | ||
| 500mg | To inquire | ||
| 1mL*10mM (DMSO) | 240.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
BIO-32546
CAS:1548743-66-3
BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of …
Formula:
C28H31F6NO3
Purity:
98.03%
Color and Shape:
Solid
Molecular weight:
543.54
Ref: TM-T10545
| 1mg | 221.00 € | ||
| 5mg | 550.00 € | ||
| 10mg | 905.00 € | ||
| 25mg | 1,890.00 € | ||
| 50mg | 3,030.00 € | ||
| 100mg | 4,874.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Siguazodan
CAS:115344-47-3
Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an …
Formula:
C14H16N6O
Purity:
99.63% - 99.77%
Color and Shape:
Solid
Molecular weight:
284.32
Ref: TM-T12913
| 1mg | 42.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 127.00 € | ||
| 25mg | 264.00 € | ||
| 50mg | 424.00 € | ||
| 100mg | 655.00 € | ||
| 200mg | 924.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Autotaxin-IN-5
CAS:2156655-99-9
Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
Formula:
C30H29N9O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
547.61
Ref: TM-T10417
| 25mg | 2,015.00 € | ||
| 50mg | 2,642.00 € | ||
| 100mg | 3,515.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
TPN171
CAS:1229018-87-4
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, …
Formula:
C24H35N5O3
Purity:
100%
Color and Shape:
Solid
Molecular weight:
441.57
Ref: TM-T13193
| 1mg | 131.00 € | ||
| 5mg | 320.00 € | ||
| 10mg | 462.00 € | ||
| 25mg | 702.00 € | ||
| 50mg | 932.00 € | ||
| 100mg | 1,283.00 € | ||
| 500mg | 2,575.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
TP-10
CAS:898563-00-3
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
Formula:
C26H19F3N4O
Purity:
98.48%
Color and Shape:
Solid
Molecular weight:
460.45
Ref: TM-T13189
| 1mg | 92.00 € | ||
| 2mg | 120.00 € | ||
| 5mg | 187.00 € | ||
| 10mg | 279.00 € | ||
| 25mg | 487.00 € | ||
| 50mg | 705.00 € | ||
| 100mg | 998.00 € | ||
| 500mg | 1,882.00 € | ||
| 1mL*10mM (DMSO) | 188.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Autotaxin-IN-4
CAS:2156655-86-4
Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
Formula:
C22H21N9O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
443.46
Ref: TM-T10416
| 25mg | 1,730.00 € | ||
| 50mg | 2,262.00 € | ||
| 100mg | 2,945.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
GSK356278
CAS:720704-34-7
GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.
Formula:
C21H25N7O2S
Purity:
99.43% - 99.79%
Color and Shape:
Solid
Molecular weight:
439.53
Ref: TM-T27475
| 2mg | 40.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 170.00 € | ||
| 50mg | 305.00 € | ||
| 100mg | 487.00 € | ||
| 200mg | 663.00 € | ||
| 500mg | 1,035.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
PF-04957325
CAS:1305115-80-3
PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can …
Formula:
C14H15F3N8OS
Purity:
99.02%
Color and Shape:
Solid
Molecular weight:
400.38
Ref: TM-T12422
| 1mg | 137.00 € | ||
| 5mg | 235.00 € | ||
| 10mg | 354.00 € | ||
| 25mg | 610.00 € | ||
| 50mg | 885.00 € | ||
| 100mg | 1,320.00 € | ||
| 1mL*10mM (DMSO) | 207.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Cudetaxestat
CAS:1782070-21-6
Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.
Formula:
C21H15Cl2F2N3O2S
Purity:
98.84%
Color and Shape:
Liquid
Molecular weight:
482.33
Ref: TM-T63190
| 1mg | 77.00 € | ||
| 5mg | 170.00 € | ||
| 10mg | 248.00 € | ||
| 25mg | 444.00 € | ||
| 50mg | 662.00 € | ||
| 100mg | 929.00 € | ||
| 200mg | 1,225.00 € | ||
| 1mL*10mM (DMSO) | 170.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
PDE9-IN-(S)-C33
CAS:2066488-39-7
PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.
Formula:
C18H20ClN5O
Purity:
98.75%
Color and Shape:
Solid
Molecular weight:
357.84
Ref: TM-T28352
| 1mg | 39.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 219.00 € | ||
| 100mg | 325.00 € | ||
| 200mg | 465.00 € | ||
| 1mL*10mM (DMSO) | 84.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Tovinontrine
CAS:2062661-53-2
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target …
Formula:
C21H26N6O2
Purity:
98.14%
Color and Shape:
Liquid
Molecular weight:
394.47
Ref: TM-T61833
| 1mg | 104.00 € | ||
| 5mg | 250.00 € | ||
| 10mg | 359.00 € | ||
| 25mg | 582.00 € | ||
| 50mg | 777.00 € | ||
| 1mL*10mM (DMSO) | 274.00 € |
Estimated delivery in United States, on Thursday 26 Jun 2025
