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PDE

PDE

Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.

Found 165 products of "PDE"

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  • Pumafentrine
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    Pumafentrine

    CAS:
    <p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>
    Formula:C29H39N3O3
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:477.64

    Ref: TM-T71691

  • Roflumilast
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    Roflumilast

    CAS:
    <p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>
    Formula:C17H14Cl2F2N2O3
    Purity:99.76% - 99.86%
    Color and Shape:Solid
    Molecular weight:403.21

    Ref: TM-T1024

  • EMD57439
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    EMD57439

    CAS:
    <p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>
    Formula:C22H23N3O4S
    Purity:99.38% - 99.57%
    Color and Shape:Solid
    Molecular weight:425.5

    Ref: TM-T25373

  • T-0156
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    T-0156

    CAS:
    <p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>
    Formula:C31H29N5O7
    Purity:98.53% - 98.76%
    Color and Shape:Soild
    Molecular weight:583.59

    Ref: TM-T23411L

  • ATX inhibitor 1
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    ATX inhibitor 1

    CAS:
    <p>ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).</p>
    Formula:C21H23Cl2N2O6P
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:501.3

    Ref: TM-T10410

  • Carbodenafil
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    Carbodenafil

    CAS:
    <p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>
    Formula:C24H32N6O3
    Purity:98.96% - 99.89%
    Color and Shape:Solid
    Molecular weight:452.55

    Ref: TM-T10676

  • Amrinone
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    Amrinone

    CAS:
    <p>Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.</p>
    Formula:C10H9N3O
    Purity:98.88% - 99.45%
    Color and Shape:Solid
    Molecular weight:187.2

    Ref: TM-T1265

  • ITI-214
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    ITI-214

    CAS:
    <p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>
    Formula:C29H29FN7O5P
    Purity:98.21%
    Color and Shape:Solid
    Molecular weight:605.56

    Ref: TM-T11689

  • Zatolmilast
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    Zatolmilast

    CAS:
    <p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>
    Formula:C21H15ClF3NO2
    Purity:98.20%
    Color and Shape:Solid
    Molecular weight:405.8

    Ref: TM-T10590

  • N-Methylbenzamide
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    N-Methylbenzamide

    CAS:
    <p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>
    Formula:C8H9NO
    Purity:99.83%
    Color and Shape:Physical Description Off-White Crystalline Solid (Ntp 1992)
    Molecular weight:135.16

    Ref: TM-T12150

  • MR-L2
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    MR-L2

    CAS:
    <p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>
    Formula:C19H16Cl3FN4O
    Purity:98.09% - 98.94%
    Color and Shape:Solid
    Molecular weight:441.71

    Ref: TM-T12103

  • Trapidil
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    Trapidil

    CAS:
    <p>Trapidil (Avantrin) is a coronary vasodilator agent.</p>
    Formula:C10H15N5
    Purity:99.42%
    Color and Shape:Solid
    Molecular weight:205.26

    Ref: TM-T0080

  • NSP-805
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    NSP-805

    CAS:
    <p>NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.</p>
    Formula:C17H19N3O2
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:297.35

    Ref: TM-T12267

  • Milrinone
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    Milrinone

    CAS:
    <p>Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.</p>
    Formula:C12H9N3O
    Purity:99.22% - 99.92%
    Color and Shape:Solid
    Molecular weight:211.22

    Ref: TM-T1096

  • Pimobendan
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    Pimobendan

    CAS:
    <p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>
    Formula:C19H18N4O2
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:334.37

    Ref: TM-T1708

  • Cilostazol
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    Cilostazol

    CAS:
    <p>Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.</p>
    Formula:C20H27N5O2
    Purity:99.58% - 99.90%
    Color and Shape:Off-White Solid
    Molecular weight:369.46

    Ref: TM-T0462

  • Acetildenafil
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    Acetildenafil

    CAS:
    <p>Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.</p>
    Formula:C25H34N6O3
    Color and Shape:Off-White To Pale Yelow Solid
    Molecular weight:466.58

    Ref: TM-T7876

  • ONO-8430506
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    ONO-8430506

    CAS:
    <p>ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.</p>
    Formula:C27H28FN3O3
    Purity:98.34%
    Color and Shape:Solid
    Molecular weight:461.53

    Ref: TM-T38759

  • CymitQuimica logo
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    PDE10A-IN-5

    <p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206937

  • Arofylline
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    Arofylline

    CAS:
    <p>Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.</p>
    Formula:C14H13ClN4O2
    Purity:98.19%
    Color and Shape:Solid
    Molecular weight:304.73

    Ref: TM-T9816