Glucokinase

Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived …

MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is …

N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 …

Acarbose is an inhibitor of α-Glucosidases with antihyperglycemic activity.

Dorzagliatin is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell …

Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 …

Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).

KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 …

AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 …

Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses …

PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM …

Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant …

Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in …

Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions …

AMG-1694 is a potent glucokinase-glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the …

Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes …

Cyclomusalenone is a potent α-glucosidase inhibitor.

LTI-291 is a glucocerebrosidase (Gcase) activator.

AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the …

4',7-DIMETHOXY-5-HYDROXYFLAVONE can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it …

1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, …

PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in …

Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has …

PFK-158 is an effective and specific inhibitor PFKFB3.

LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

1.Ginkgolic acid C13: 0exhibits the highest α-glucosidase inhibitory activity.

AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used …

Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect

3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several …

1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important …

AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.

AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).

1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.

Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to …

Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.

(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.

Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.

ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting …

Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and …

Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against …

Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and …

Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).

Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as …

Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. …