Glucokinase
Glucokinase (GK) is an enzyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate, a critical step in glycolysis. GK is predominantly expressed in the liver and pancreas, where it plays a key role in regulating blood glucose levels. Inhibitors of GK are of interest in the study of metabolic disorders such as diabetes, as they can modulate glucose metabolism and insulin secretion. At CymitQuimica, we provide glucokinase inhibitors to support your research in diabetes, metabolism, and therapeutic development.
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AP-III-a4
CAS:1177827-73-4
AP-III-a4 (ENOblock) (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 …
Formula:
C31H43FN8O3
Purity:
99.90%
Color and Shape:
Solid
Molecular weight:
594.72
Ref: TM-T6759
| 1mg | 51.00 € | ||
| 5mg | 166.00 € | ||
| 10mg | 260.00 € | ||
| 25mg | 525.00 € | ||
| 50mg | 730.00 € | ||
| 100mg | 1,012.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
ML198
CAS:1380716-06-2
ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.
Formula:
C17H14N4O
Purity:
98.31%
Color and Shape:
Solid
Molecular weight:
290.32
Ref: TM-T8986
| 2mg | 48.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 248.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 551.00 € | ||
| 200mg | 728.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AMG-3969
CAS:1361224-53-4
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
Formula:
C21H20F6N4O3S
Purity:
99.65%
Color and Shape:
Solid
Molecular weight:
522.46
Ref: TM-TQ0055
| 1mg | 120.00 € | ||
| 5mg | 232.00 € | ||
| 10mg | 364.00 € | ||
| 25mg | 605.00 € | ||
| 50mg | 837.00 € | ||
| 100mg | 1,154.00 € | ||
| 1mL*10mM (DMSO) | 266.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AMG-1694
CAS:1361217-07-3
AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic …
Formula:
C23H30F3N3O4S2
Purity:
97.97%
Color and Shape:
Solid
Molecular weight:
533.63
Ref: TM-T14212
| 1mg | 353.00 € | ||
| 5mg | 822.00 € | ||
| 10mg | 1,138.00 € | ||
| 25mg | 1,633.00 € | ||
| 50mg | 2,032.00 € | ||
| 100mg | 2,616.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
ARRY-403
CAS:1138669-65-4
ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients …
Formula:
C20H18N6O3S2
Purity:
98.69%
Color and Shape:
Solid
Molecular weight:
454.52
Ref: TM-T30142
| 1mg | 923.00 € | ||
| 5mg | 1,846.00 € | ||
| 10mg | 2,494.00 € | ||
| 25mg | 3,692.00 € | ||
| 50mg | 4,969.00 € | ||
| 100mg | 6,702.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Cefetrizole
CAS:65307-12-2
Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
Formula:
C16H15N5O4S3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
437.52
Ref: TM-T10751
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
YZ9
CAS:6093-71-6
Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as …
Formula:
C12H10O5
Purity:
99.13%
Color and Shape:
Solid
Molecular weight:
234.2
Ref: TM-T23552
| 100mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
AZ PFKFB3 26
CAS:1704740-52-2
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 …
Formula:
C24H26N4O2
Purity:
98.91%
Color and Shape:
Solid
Molecular weight:
402.49
Ref: TM-T14365
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 167.00 € | ||
| 50mg | 277.00 € | ||
| 100mg | 386.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
AZD-1656
CAS:919783-22-5
AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used …
Formula:
C24H26N6O5
Purity:
99.37%
Color and Shape:
Solid
Molecular weight:
478.5
Ref: TM-T26712
| 1mg | 92.00 € | ||
| 2mg | 120.00 € | ||
| 5mg | 187.00 € | ||
| 10mg | 310.00 € | ||
| 25mg | 625.00 € | ||
| 50mg | 937.00 € | ||
| 1mL*10mM (DMSO) | 204.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
PF-04937319
CAS:1245603-92-2
PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.
Formula:
C22H20N6O4
Purity:
98.61%
Color and Shape:
Solid
Molecular weight:
432.43
Ref: TM-T16479
| 1mg | 45.00 € | ||
| 2mg | 58.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 151.00 € | ||
| 25mg | 302.00 € | ||
| 50mg | 551.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
WAY-297848
CAS:404360-27-6
WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, …
Formula:
C13H13ClN2O2S
Purity:
98.19%
Color and Shape:
Liquid
Molecular weight:
296.77
Ref: TM-T77784
| 1mg | 35.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 156.00 € | ||
| 50mg | 221.00 € | ||
| 100mg | 333.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
KDM4-IN-2
CAS:2369607-62-3
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 …
Formula:
C25H26N6O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
426.51
Ref: TM-T11749
| 25mg | 1,410.00 € | ||
| 50mg | 1,845.00 € | ||
| 100mg | 2,329.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
