IDO
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan, leading to the production of kynurenine and other metabolites. IDO plays a role in immune tolerance and is often upregulated in cancer and chronic inflammatory conditions. Inhibitors of IDO are being explored as potential immunotherapeutic agents in cancer and autoimmune diseases. At CymitQuimica, we provide IDO inhibitors to support your research in immunology, oncology, and metabolic regulation.
Found 84 products of "IDO"
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GNF-PF-3777
CAS:GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
Formula:C15H7N3O4Purity:97.88%Color and Shape:SolidMolecular weight:293.23LY3381916
CAS:IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.Formula:C23H25FN2O3Purity:99.3%Color and Shape:SolidMolecular weight:396.45Ref: TM-T11901
1mg38.00€2mg50.00€5mg82.00€10mg124.00€25mg203.00€50mg326.00€100mg512.00€1mL*10mM (DMSO)71.00€IDO-IN-13
CAS:IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).Formula:C26H17F3N4OPurity:99.29%Color and Shape:SolidMolecular weight:458.43Ref: TM-T11616
1mg58.00€5mg113.00€10mg165.00€25mg230.00€50mg338.00€100mg490.00€1mL*10mM (DMSO)131.00€BMT-297376
CAS:BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.Formula:C23H29F2N3O3Color and Shape:SolidMolecular weight:433.5IDO-IN-15
CAS:IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Formula:C29H39N5O4Color and Shape:SolidMolecular weight:521.662NLG802
CAS:NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
Formula:C20H30ClN3O3Purity:99.61%Color and Shape:SolidMolecular weight:395.92IDO1-IN-11
CAS:IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.Formula:C22H17ClFN3O3Color and Shape:SolidMolecular weight:425.84IDO1-IN-7
CAS:IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.Formula:C22H19ClFN3O3Color and Shape:SolidMolecular weight:427.86IDO1/TDO-IN-8
IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.Formula:C17H14N2SColor and Shape:SolidMolecular weight:278.37PROTAC IDO1 Degrader-1
CAS:First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.Formula:C40H53BrFN9O13Color and Shape:SolidMolecular weight:966.816CAY10581
CAS:CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50Formula:C22H21NO4Color and Shape:SolidMolecular weight:363.41XW-032
XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.Color and Shape:Odour Solidhuman TDO2-IN-1
Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.Formula:C30H36N4O5Color and Shape:SolidMolecular weight:532.631NU227326
CAS:NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).Formula:C53H61FN8O7Color and Shape:SolidMolecular weight:941.099TDO-IN-2
TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.Formula:C20H15N3O3Color and Shape:SolidMolecular weight:345.11134β-Cembrenediol
CAS:β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate.Formula:C20H34O2Color and Shape:SolidMolecular weight:306.49IDO1-IN-23
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].Purity:98%Color and Shape:Odour SolidIDO1/TDO-IN-7
IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.Color and Shape:Odour SolidIDO1-IN-24
IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.Formula:C18H22N2O4Molecular weight:330.15796NU223612
CAS:"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."Formula:C49H55FN6O9Color and Shape:SolidMolecular weight:890.99IDO1-IN-12
CAS:IDO1-IN-12 is a potent and orally available IDO1 inhibitor.Formula:C21H19F3N2O2Color and Shape:SolidMolecular weight:388.39IDO1/TDO-IN-4
CAS:IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO.Formula:C14H10N4Purity:98.12% - 98.88%Color and Shape:SolidMolecular weight:234.26Ref: TM-T60318
1mg48.00€5mg99.00€10mg168.00€25mg281.00€50mg416.00€100mgTo inquire1mL*10mM (DMSO)109.00€IDO1 Protein, Mouse, Recombinant (His)
IDO Protein, Mouse, Recombinant (His) is expressed in E.Purity:≥ 90 % as determined by SDS-PAGE. - ≥ 90 % as determined by SDS-PAGE.Color and Shape:Lyophilized PowderMolecular weight:46.47 kDa (predicted)(Rac)-IDO1-IN-5
CAS:(Rac)-IDO1-IN-5 is a racemic, potent IDO1 inhibitor; selective for apo-IDO1, it crosses the blood-brain barrier.Formula:C23H25FN2O3Color and Shape:SolidMolecular weight:396.45IDO1 Protein, Human, Recombinant (His)
IDO Protein, Human, Recombinant (His) is expressed in E.Color and Shape:Lyophilized PowderMolecular weight:46 kDa (predicted); 44 kDa (reducing conditions)(S)-IDO1-IN-5
CAS:(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 μΜ).Formula:C23H25FN2O3Color and Shape:SolidMolecular weight:396.45Anti-IDO1 Antibody (9Y885)
Anti-IDO1 Antibody (9Y885) is an antibody targeting IDO1. Anti-IDO1 Antibody (9Y885) can be used in ELISA, IHC.Color and Shape:Odour LiquidIDO1 Protein, Human, Recombinant
IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.Color and Shape:Lyophilized PowderMolecular weight:45.2 kDa (predicted); 46 kDa (reducing conditions)BMS-986242
CAS:BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.Formula:C24H24ClFN2OPurity:98.9%Color and Shape:SolidMolecular weight:410.91Linrodostat
CAS:Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.Formula:C24H24ClFN2OPurity:99.54% - 99.71%Color and Shape:SolidMolecular weight:410.91(S)-Indoximod
CAS:(S)-Indoximod (L-Abrine) is an indoleamine-2,3-dioxygenase (IDO) inhibitor for cancer research.Formula:C12H14N2O2Purity:95.39% - 99.69%Color and Shape:SolidMolecular weight:218.253-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Formula:C7H6N4Purity:99.16% - >99.99%Color and Shape:SolidMolecular weight:146.15Ref: TM-T4108
2mg39.00€5mg52.00€10mg93.00€25mg166.00€50mg248.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)52.00€Indoximod
CAS:Indoximod (NLG-8189) is a methylated tryptophan that inhibits IDO to boost T cell function by preventing tryptophan depletion.Formula:C12H14N2O2Purity:97.82% - 99.55%Color and Shape:SolidMolecular weight:218.25IDO-IN-7
CAS:IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.Formula:C18H22N2OPurity:99.32% - 99.9%Color and Shape:SolidMolecular weight:282.38Epacadostat
CAS:Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.Cost-effective and quality-assured.Formula:C11H13BrFN7O4SPurity:98% - >99.99%Color and Shape:SolidMolecular weight:438.23Ref: TM-T3548
1g757.00€2g1,035.00€5mg47.00€10mg70.00€25mg87.00€50mg111.00€100mg187.00€200mg311.00€500mg525.00€1mL*10mM (DMSO)50.00€IDO-IN-1
CAS:IDO-IN-1: potent IDO inhibitor, IC50 of 59 nM (enzyme), 12 nM (HeLa cells).Formula:C9H7BrFN5O2Purity:99.91%Color and Shape:SolidMolecular weight:316.09Ref: TM-T7181
1mg49.00€5mg96.00€10mg155.00€25mg269.00€50mg404.00€100mg567.00€200mg763.00€1mL*10mM (DMSO)110.00€Navoximod
CAS:Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).Formula:C18H21FN2O2Purity:99.37%Color and Shape:SolidMolecular weight:316.37Ref: TM-TQ0071
1mg150.00€5mg313.00€10mg470.00€25mg600.00€50mg745.00€100mg1,044.00€1mL*10mM (DMSO)318.00€Linrodostat mesylate
CAS:Linrodostat (BMS-986205) is an oral IDO1 inhibitor that boosts immune response and has anti-cancer properties.Formula:C25H28ClFN2O4SPurity:98%Color and Shape:SolidMolecular weight:507.02IDO1-IN-1
CAS:IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.Formula:C7H7N3SPurity:99.36%Color and Shape:Slightly Yellow To Beige-Green Crystalline PowderMolecular weight:165.22LM10
CAS:TDO inhibitor; IC50: human 0.62 μM, mouse 2 μM; selective over IDO, MAOs; hinders TDO+ tumor growth in mice; orally active.Formula:C11H8FN5Purity:98.78% - 99.94%Color and Shape:SolidMolecular weight:229.21PCC0208009
CAS:PCC0208009 (IDO-IN-2) is an IDO inhibitor.Formula:C29H35N7OPurity:99.89%Color and Shape:SolidMolecular weight:497.63Ref: TM-T4142
1mg44.00€2mg56.00€5mg93.00€10mg142.00€25mg258.00€50mg439.00€100mg605.00€1mL*10mM (DMSO)92.00€IDO5L
CAS:IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).Formula:C9H7ClFN5O2Purity:99.49% - 99.75%Color and Shape:SolidMolecular weight:271.64Ref: TM-T2647
10mg50.00€25mg86.00€50mg124.00€100mg187.00€200mg321.00€500mg505.00€1mL*10mM (DMSO)35.00€PF-06840003
CAS:PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.Formula:C12H9FN2O2Purity:99.10%Color and Shape:SolidMolecular weight:232.21Ref: TM-T4307
2mg34.00€5mg50.00€10mg88.00€25mg102.00€50mg120.00€100mg178.00€200mg268.00€1mL*10mM (DMSO)55.00€Necrostatin 2 racemate
CAS:Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.Formula:C13H12ClN3O2Purity:98% - 99.5%Color and Shape:SolidMolecular weight:277.71Ref: TM-T7504
1mg62.00€5mg102.00€10mg160.00€25mg289.00€50mg500.00€100mg705.00€500mg1,431.00€1mL*10mM (DMSO)133.00€DP00477
CAS:DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM.Formula:C17H11ClF3N3OSColor and Shape:SolidMolecular weight:397.8IDO-IN-12
CAS:IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).Formula:C13H11BrFN5O3SPurity:99.727%Color and Shape:SolidMolecular weight:416.23Ref: TM-T11615
1mg84.00€5mg170.00€10mg250.00€25mg394.00€50mg512.00€100mg713.00€1mL*10mM (DMSO)178.00€IACS-8968 S-enantiomer
CAS:IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Formula:C17H18F3N5O2Purity:98%Color and Shape:SolidMolecular weight:381.35IACS-8968
CAS:IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Formula:C17H18F3N5O2Purity:98%Color and Shape:SolidMolecular weight:381.35IDO1-IN-18
CAS:IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has potential for cancer disease research.Formula:C23H18F4N2O3Color and Shape:SolidMolecular weight:446.39IDO-IN-8
CAS:IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Formula:C18H21FN2O2Purity:98%Color and Shape:SolidMolecular weight:316.37
