HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
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PT2399
CAS:1672662-14-4
PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.
Formula:
C17H10F5NO4S
Purity:
98.8% - 99.07%
Color and Shape:
Solid
Molecular weight:
419.32
Ref: TM-T12675L
| 1mg | 96.00 € | ||
| 5mg | 230.00 € | ||
| 10mg | 346.00 € | ||
| 25mg | 625.00 € | ||
| 50mg | 922.00 € | ||
| 100mg | 1,290.00 € | ||
| 1mL*10mM (DMSO) | 253.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Hydroxycitric acid tripotassium hydrate
CAS:6100-05-6
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor …
Formula:
C6H7K3O8
Purity:
95%
Color and Shape:
White Solid Crystalline
Molecular weight:
324.41
Ref: TM-T11589
| 1g | 62.00 € | ||
| 5g | 93.00 € | ||
| 10g | 123.00 € | ||
| 500mg | 48.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Naphthofluorescein
CAS:61419-02-1
Naphthofluorescein: Mint3 inhibitor with antitumor/anti-inflammatory effect, non-toxic; doubles as pH-sensitive fluorescence probe.
Formula:
C28H16O5
Purity:
99.34%
Color and Shape:
Solid
Molecular weight:
432.42
Ref: TM-T36953
| 25mg | 51.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
1,4-DPCA
CAS:331830-20-7
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation …
Formula:
C13H8N2O3
Purity:
97.75%
Color and Shape:
Solid
Molecular weight:
240.21
Ref: TM-T21653
| 5mg | 51.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 151.00 € | ||
| 50mg | 232.00 € | ||
| 100mg | 372.00 € | ||
| 200mg | 547.00 € | ||
| 500mg | 863.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Adaptaquin
CAS:385786-48-1
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
Formula:
C21H16ClN3O2
Purity:
98.35%
Color and Shape:
Solid
Molecular weight:
377.82
Ref: TM-T22022
| 5mg | 34.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 150.00 € | ||
| 100mg | 228.00 € | ||
| 200mg | 324.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Izilendustat
CAS:1303512-02-8
Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.
Formula:
C22H28ClN3O4
Purity:
99.95%
Color and Shape:
Solid
Molecular weight:
433.93
Ref: TM-T64336
| 5mg | 44.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 107.00 € | ||
| 50mg | 171.00 € | ||
| 100mg | 266.00 € | ||
| 200mg | 387.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HIF1-IN-3
CAS:333314-79-7
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can …
Formula:
C26H24N2O3
Purity:
99.48%
Color and Shape:
Liquid
Molecular weight:
412.48
Ref: TM-T9890
| 5mg | 44.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 112.00 € | ||
| 50mg | 205.00 € | ||
| 100mg | 282.00 € | ||
| 200mg | 409.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but …
Formula:
C32H61N3O10P2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
709.79
Ref: TM-T78834
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
ML228
CAS:1357171-62-0
ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.
Formula:
C27H21N5
Purity:
99.03%
Color and Shape:
Solid
Molecular weight:
415.49
Ref: TM-T7836
| 1mg | 44.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 157.00 € | ||
| 25mg | 334.00 € | ||
| 50mg | 524.00 € | ||
| 100mg | 737.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM …
Purity:
98%
Ref: TM-T82198
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Amifostine
CAS:20537-88-6
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
Formula:
C5H15N2O3PS
Purity:
99.88%
Color and Shape:
White Solid
Molecular weight:
214.22
Ref: TM-T3289
| 5mg | 37.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 104.00 € | ||
| 50mg | 186.00 € | ||
| 100mg | 311.00 € | ||
| 200mg | 464.00 € | ||
| 500mg | 738.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HIF-1 inhibitor-4
CAS:333357-56-5
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.
Formula:
C18H19IN2O2
Purity:
99.17%
Color and Shape:
Liquid
Molecular weight:
422.26
Ref: TM-T67767
| 1mg | 48.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 156.00 € | ||
| 25mg | 306.00 € | ||
| 50mg | 496.00 € | ||
| 100mg | 780.00 € | ||
| 500mg | 1,538.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant …
Formula:
C28H37FN4O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
544.68
Ref: TM-T79720
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HIF-1α-IN-2 hydrochloride
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of …
Formula:
C21H20ClN3OS
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
397.92
Ref: TM-T78123
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HIF-IN-1
CAS:2393928-76-0
HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell …
Formula:
C17H12N2O
Purity:
99.48%
Color and Shape:
Solid
Molecular weight:
260.29
Ref: TM-T60413
| 1mg | 74.00 € | ||
| 5mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HIF-1α-IN-2
CAS:2762315-06-8
HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and …
Formula:
C21H19N3OS
Purity:
98.45%
Color and Shape:
Liquid
Molecular weight:
361.46
Ref: TM-T61349
| 2mg | 89.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
IMM-H007
CAS:1221412-23-2
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
Formula:
C22H23N5O8
Purity:
97.73%
Color and Shape:
Solid
Molecular weight:
485.45
Ref: TM-T9010
| 1mg | 61.00 € | ||
| 5mg | 142.00 € | ||
| 10mg | 212.00 € | ||
| 25mg | 369.00 € | ||
| 50mg | 523.00 € | ||
| 100mg | 709.00 € | ||
| 500mg | 1,423.00 € | ||
| 1mL*10mM (DMSO) | 210.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
TP0463518
CAS:1558021-37-6
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 …
Formula:
C20H18ClN3O6
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
431.83
Ref: TM-T5392
| 5mg | 51.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 118.00 € | ||
| 50mg | 184.00 € | ||
| 100mg | 348.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
HNHA
CAS:926908-04-5
HNHA is an inhibitor of HDAC.
Formula:
C17H21NO2S
Purity:
98.04%
Color and Shape:
Solid
Molecular weight:
303.42
Ref: TM-T21806
| 1mg | 69.00 € | ||
| 2mg | 87.00 € | ||
| 5mg | 124.00 € | ||
| 10mg | 228.00 € | ||
| 25mg | 545.00 € | ||
| 50mg | 778.00 € | ||
| 100mg | 1,079.00 € | ||
| 500mg | 2,124.00 € | ||
| 1mL*10mM (DMSO) | 134.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Ethyl 3,4-dihydroxybenzoate
CAS:3943-89-3
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in …
Formula:
C9H10O4
Purity:
≥95%
Color and Shape:
White Crystal Or Powder
Molecular weight:
182.17
Ref: TM-T5684
| 500mg | 48.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
