HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 142 products of "HIF/HIF Prolyl-Hydroxylase"
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Hydroxycitric acid tripotassium hydrate
CAS:<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>Formula:C6H7K3O8Purity:99.85%Color and Shape:White Solid CrystallineMolecular weight:324.417-Hydroxyneolamellarin A
CAS:<p>7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.</p>Formula:C24H19NO5Color and Shape:SolidMolecular weight:401.41HIF-1 α (556-574)
CAS:<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Formula:C101H150D2N20O34S2Purity:98%Color and Shape:SolidMolecular weight:2254.6Axl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Formula:C14H19ClO8Purity:98%Color and Shape:SolidMolecular weight:350.75(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Formula:C41H46N6O6SColor and Shape:SolidMolecular weight:750.91HSP90-IN-30
<p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>Formula:C20H39B12N4O2Molecular weight:499.41897HIF-1 inhibitor-4
CAS:<p>HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.</p>Formula:C18H19IN2O2Purity:99.26%Color and Shape:SolidMolecular weight:422.26NF-κB/HIF-1α-IN-1
<p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>Formula:C24H27N7O4Color and Shape:SolidMolecular weight:477.21245Izilendustat
CAS:<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formula:C22H28ClN3O4Purity:99.95%Color and Shape:SolidMolecular weight:433.93ZG-2305
<p>ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.</p>Formula:C17H11Cl2N3O5Color and Shape:SolidMolecular weight:408.19HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Color and Shape:Odour Solid1,4-DPCA
CAS:<p>1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting</p>Formula:C13H8N2O3Purity:97.77%Color and Shape:SolidMolecular weight:240.21HIF1-IN-3
CAS:<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Formula:C26H24N2O3Purity:99.59%Color and Shape:SolidMolecular weight:412.48IOX2-NH2-Methyl
<p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>Formula:C20H19N3O5Purity:97.64% - 99.31%Color and Shape:SolidMolecular weight:381.39ISM012-042
<p>ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.</p>Formula:C26H28N6O4Color and Shape:SolidMolecular weight:488.538Mersalyl
CAS:<p>Mersalyl is an organic mercurial diuretic.</p>Formula:C13H16HgNNaO6Color and Shape:SolidMolecular weight:505.854HIF-1 inhibitor-5
<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>Formula:C28H35NO5Color and Shape:SolidMolecular weight:465.58TAT-cyclo-CLLFVY
CAS:<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formula:C111H188N42O24S2Purity:98%Color and Shape:SolidMolecular weight:2559.1ML228
CAS:<p>ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.</p>Formula:C27H21N5Purity:99.54%Color and Shape:SolidMolecular weight:415.49Zifcasiran
CAS:<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Formula:C737H972F20N211O349P43S8Color and Shape:SolidMolecular weight:20339.13
