HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 151 products for "HIF/HIF Prolyl-Hydroxylase".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Oltipraz
CAS:Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Formula:C8H6N2S3Purity:98.79% - 99.77%Color and Shape:SolidMolecular weight:226.34HIF-1 α (556-574)
CAS:HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Formula:C101H150D2N20O34S2Purity:98%Color and Shape:SolidMolecular weight:2254.6HIF-2α-IN-7
CAS:HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.Formula:C18H9F6NO2Color and Shape:SolidMolecular weight:385.26Axl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFormula:C14H19ClO8Purity:98%Color and Shape:SolidMolecular weight:350.75(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Formula:C41H46N6O6SColor and Shape:SolidMolecular weight:750.91HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Formula:C20H39B12N4O2Color and Shape:SolidMolecular weight:499.41897NF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formula:C24H27N7O4Color and Shape:SolidMolecular weight:477.21245HIF-1 inhibitor-4
CAS:HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Formula:C18H19IN2O2Purity:99.26%Color and Shape:SolidMolecular weight:422.26ZG-2305
CAS:ZG-2305, Selective oral FIH inhibitor (Ki=79.6 nM), increases EGLN3 expression, reduces lipids, for obesity and fatty liver disease research.Formula:C17H11Cl2N3O5Color and Shape:SolidMolecular weight:408.19Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purity:99.86%Color and Shape:White SolidMolecular weight:433.93Casdatifan
CAS:Casdatifan (AB521) is an orally bioavailable HIF-2α inhibitor that blocks HIF-2α/HIF-1β heterodimerization and shows antitumor activity in ccRCC models.Formula:C21H17F4NO3SMolecular weight:439.421,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFormula:C13H8N2O3Purity:97.77%Color and Shape:SolidMolecular weight:240.21HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Color and Shape:Odour SolidTAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formula:C111H188N42O24S2Purity:98%Color and Shape:SolidMolecular weight:2559.1HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormula:C26H24N2O3Purity:99.59%Color and Shape:White SolidMolecular weight:412.48Fibrostatin C
CAS:Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.Formula:C18H19NO8SColor and Shape:SolidMolecular weight:409.41cisVH 298
CAS:cisVH 298 is a negative control for VH 298. Exhibits no detectable binding of VHL.Formula:C27H33N5O4SColor and Shape:SolidMolecular weight:523.65HIF-1 inhibitor-5
HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1Formula:C28H35NO5Color and Shape:SolidMolecular weight:465.58Mersalyl
CAS:Mersalyl is an organic mercurial diuretic.Formula:C13H16HgNNaO6Color and Shape:SolidMolecular weight:505.854ML228
CAS:ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Formula:C27H21N5Purity:99.54%Color and Shape:SolidMolecular weight:415.49
