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HIF/HIF Prolyl-Hydroxylase

HIF/HIF Prolyl-Hydroxylase

Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.

Found 142 products of "HIF/HIF Prolyl-Hydroxylase"

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  • ZG-2033
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    ZG-2033

    CAS:
    <p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>
    Formula:C15H14N2O2S
    Color and Shape:Solid
    Molecular weight:286.35

    Ref: TM-T203229

  • TAT-cyclo-CLLFVY
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    TAT-cyclo-CLLFVY

    CAS:
    <p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>
    Formula:C111H188N42O24S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2559.1

    Ref: TM-TP2046

  • HIF1-IN-3 
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    HIF1-IN-3 

    CAS:
    <p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>
    Formula:C26H24N2O3
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:412.48

    Ref: TM-T9890

  • Izilendustat
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    Izilendustat

    CAS:
    <p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>
    Formula:C22H28ClN3O4
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:433.93

    Ref: TM-T64336

  • IOX2-NH2-Methyl
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    IOX2-NH2-Methyl

    <p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>
    Formula:C20H19N3O5
    Purity:97.64% - 99.31%
    Color and Shape:Solid
    Molecular weight:381.39

    Ref: TM-T206026

  • Mersalyl
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    Mersalyl

    CAS:
    <p>Mersalyl is an organic mercurial diuretic.</p>
    Formula:C13H16HgNNaO6
    Color and Shape:Solid
    Molecular weight:505.854

    Ref: TM-T33297

  • CymitQuimica logo
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    HSP90-IN-30

    <p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>
    Formula:C20H39B12N4O2
    Molecular weight:499.41897

    Ref: TM-T209734

  • Fibrostatin C
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    Fibrostatin C

    CAS:
    <p>Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.</p>
    Formula:C18H19NO8S
    Color and Shape:Solid
    Molecular weight:409.41

    Ref: TM-T24062

  • CymitQuimica logo
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    VHL-IN-1

    <p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>
    Formula:C28H37FN4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:544.68

    Ref: TM-T79720

  • HIF-1α-IN-2
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    HIF-1α-IN-2

    CAS:
    <p>HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.</p>
    Formula:C21H19N3OS
    Purity:99.90% - >99.99%
    Color and Shape:Solid
    Molecular weight:361.46

    Ref: TM-T61349

  • 1,4-DPCA ethyl ester
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    1,4-DPCA ethyl ester

    CAS:
    <p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>
    Formula:C15H12N2O3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:268.27

    Ref: TM-T36796

  • KG-548
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    KG-548

    CAS:
    <p>KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.</p>
    Formula:C9H4F6N4
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:282.15

    Ref: TM-T60539

  • HIF-IN-1
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    HIF-IN-1

    CAS:
    <p>HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.</p>
    Formula:C17H12N2O
    Purity:99.48%
    Color and Shape:Solid
    Molecular weight:260.29

    Ref: TM-T60413

  • dencichine
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    dencichine

    CAS:
    <p>Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.</p>
    Formula:C5H8N2O5
    Purity:99.93% - ≥95%
    Color and Shape:Solid
    Molecular weight:176.13

    Ref: TM-TL0001

  • N-Oxalylglycine
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    N-Oxalylglycine

    CAS:
    <p>N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.</p>
    Formula:C4H5NO5
    Purity:99.23%
    Color and Shape:Colourless Solid
    Molecular weight:147.09

    Ref: TM-T21634

  • Dapagliflozin
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    Dapagliflozin

    CAS:
    <p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>
    Formula:C21H25ClO6
    Purity:99.5% - 99.93%
    Color and Shape:Solid
    Molecular weight:408.87

    Ref: TM-T2389

  • FG-2216
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    FG-2216

    CAS:
    <p>FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.</p>
    Formula:C12H9ClN2O4
    Purity:97.1% - >99.99%
    Color and Shape:Solid
    Molecular weight:280.66

    Ref: TM-T2445

  • Glucosamine sulfate
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    Glucosamine sulfate

    CAS:
    <p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>
    Formula:C6H13NO5·H2SO4
    Purity:99.64%
    Color and Shape:White Crystal
    Molecular weight:277.25

    Ref: TM-T2792

  • ZINC13466751
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    ZINC13466751

    CAS:
    <p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>
    Formula:C20H21N5O2
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:363.41

    Ref: TM-T13398

  • DMOG
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    DMOG

    CAS:
    <p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>
    Formula:C6H9NO5
    Purity:80.23% - 99.98%
    Color and Shape:Solid
    Molecular weight:175.14

    Ref: TM-T1939