HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
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Fraxinellone
CAS:28808-62-0
1.
Formula:
C14H16O3
Purity:
99.35%
Color and Shape:
Solid
Molecular weight:
232.27
Ref: TM-T6S0071
| 5mg | 71.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 176.00 € | ||
| 50mg | 262.00 € | ||
| 100mg | 396.00 € | ||
| 1mL*10mM (DMSO) | 85.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
AKBA
CAS:67416-61-9
AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.
Formula:
C32H48O5
Purity:
97.85% - 99.77%
Color and Shape:
Solid
Molecular weight:
512.72
Ref: TM-T5S1569
| 1g | 1,822.00 € | ||
| 1mg | 42.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 115.00 € | ||
| 25mg | 183.00 € | ||
| 50mg | 273.00 € | ||
| 100mg | 431.00 € | ||
| 500mg | 1,162.00 € | ||
| 1mL*10mM (DMSO) | 143.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
FG-2216
CAS:223387-75-5
FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced …
Formula:
C12H9ClN2O4
Purity:
100% - 99%
Color and Shape:
Solid
Molecular weight:
280.66
Ref: TM-T2445
| 2mg | 39.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 167.00 € | ||
| 50mg | 245.00 € | ||
| 100mg | 363.00 € | ||
| 500mg | 857.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
IDF-11774
CAS:1429054-28-3
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
Formula:
C23H32N2O2
Purity:
98.05%
Color and Shape:
Solid
Molecular weight:
368.51
Ref: TM-T5537
| 1mg | 60.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 305.00 € | ||
| 50mg | 455.00 € | ||
| 100mg | 662.00 € | ||
| 1mL*10mM (DMSO) | 90.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
IOX2
CAS:931398-72-0
IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for …
Formula:
C19H16N2O5
Purity:
98% - 99.81%
Color and Shape:
Solid
Molecular weight:
352.34
Ref: TM-T1823
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 172.00 € | ||
| 50mg | 320.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
ZINC13466751
CAS:117953-17-0
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).
Formula:
C20H21N5O2
Purity:
99.94%
Color and Shape:
Solid
Molecular weight:
363.41
Ref: TM-T13398
| 1mg | 49.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 160.00 € | ||
| 25mg | 254.00 € | ||
| 50mg | 351.00 € | ||
| 100mg | 450.00 € | ||
| 200mg | 627.00 € | ||
| 1mL*10mM (DMSO) | 105.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Glucosamine sulfate
CAS:29031-19-4
Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry …
Formula:
C6H13NO5·H2SO4
Purity:
99.49%
Color and Shape:
White Crystal
Molecular weight:
277.25
Ref: TM-T2792
| 500mg | 48.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
M1001
CAS:874590-32-6
M1001 is a HIF-2α agonist.
Formula:
C17H17N3O2S
Purity:
98.83%
Color and Shape:
Solid
Molecular weight:
327.4
Ref: TM-T7802
| 1mg | 60.00 € | ||
| 5mg | 126.00 € | ||
| 10mg | 200.00 € | ||
| 25mg | 372.00 € | ||
| 50mg | 555.00 € | ||
| 100mg | 768.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Deoxyshikonin
CAS:43043-74-9
1.
Formula:
C16H16O4
Purity:
99.36% - ≥95%
Color and Shape:
Solid
Molecular weight:
272.3
Ref: TM-T5S2347
| 10mg | 125.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
PHD-1-IN-1
CAS:2009343-14-8
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
Formula:
C13H8N4
Purity:
99.78%
Color and Shape:
Solid
Molecular weight:
220.23
Ref: TM-T9627
| 1mg | 66.00 € | ||
| 5mg | 142.00 € | ||
| 10mg | 220.00 € | ||
| 25mg | 397.00 € | ||
| 50mg | 599.00 € | ||
| 100mg | 899.00 € | ||
| 1mL*10mM (DMSO) | 156.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
GN44028
CAS:1421448-26-1
GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but …
Formula:
C18H15N3O2
Purity:
98.20%
Color and Shape:
Solid
Molecular weight:
305.33
Ref: TM-T15396
| 1mg | 68.00 € | ||
| 5mg | 130.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 315.00 € | ||
| 50mg | 449.00 € | ||
| 100mg | 594.00 € | ||
| 200mg | 800.00 € | ||
| 1mL*10mM (DMSO) | 144.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
BAY 87-2243
CAS:1227158-85-1
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
Formula:
C26H26F3N7O2
Purity:
98% - 99.77%
Color and Shape:
Solid
Molecular weight:
525.53
Ref: TM-T2488
| 2mg | 45.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 105.00 € | ||
| 25mg | 219.00 € | ||
| 50mg | 424.00 € | ||
| 100mg | 643.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Chlorogenic Acid
CAS:327-97-9
Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective …
Formula:
C16H18O9
Purity:
98.76% - 99.67%
Color and Shape:
Solid
Molecular weight:
354.31
Ref: TM-T2805
| 500mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 60.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
JNJ-42041935
CAS:1193383-09-3
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective …
Formula:
C12H6ClF3N4O3
Purity:
99.58% - ≥95%
Color and Shape:
Solid
Molecular weight:
346.65
Ref: TM-T3180
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 207.00 € | ||
| 50mg | 346.00 € | ||
| 100mg | 555.00 € | ||
| 500mg | 1,170.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Acriflavine Hydrochloride
CAS:8063-24-9
Acriflavine HCl is a HIF-1α inhibitor reducing PGK1, VEGF, and HIF-1α levels both in vitro …
Formula:
C14H14ClN3
Purity:
99.69%
Color and Shape:
Solid
Molecular weight:
259.73
Ref: TM-T19832
| 500mg | 48.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
dencichine
CAS:5302-45-4
Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of …
Formula:
C5H8N2O5
Purity:
≥95%
Color and Shape:
Solid
Molecular weight:
176.13
Ref: TM-TL0001
| 1mg | 61.00 € | ||
| 5mg | 130.00 € | ||
| 10mg | 203.00 € | ||
| 25mg | 343.00 € | ||
| 1mL*10mM (DMSO) | 111.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
DMOG
CAS:89464-63-1
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
Formula:
C6H9NO5
Purity:
80.23% - 99.98%
Color and Shape:
Solid
Molecular weight:
175.14
Ref: TM-T1939
| 25mg | 51.00 € | ||
| 50mg | 63.00 € | ||
| 100mg | 87.00 € | ||
| 200mg | 157.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
MK-8617
CAS:1187990-87-9
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
Formula:
C24H21N5O4
Purity:
100% - 99.63%
Color and Shape:
Solid
Molecular weight:
443.45
Ref: TM-T4106
| 1mg | 35.00 € | ||
| 2mg | 47.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 167.00 € | ||
| 50mg | 307.00 € | ||
| 100mg | 456.00 € | ||
| 200mg | 650.00 € | ||
| 500mg | 1,013.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
KC7F2
CAS:927822-86-4
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
Formula:
C16H16Cl4N2O4S4
Purity:
98% - 99.11%
Color and Shape:
Solid
Molecular weight:
570.38
Ref: TM-T3169
| 5mg | 51.00 € | ||
| 10mg | 56.00 € | ||
| 25mg | 90.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 238.00 € | ||
| 200mg | 309.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
2,4-DPD
CAS:41438-38-4
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
Formula:
C11H13NO4
Purity:
99.74%
Color and Shape:
Yellow Solid Crystalline
Molecular weight:
223.23
Ref: TM-T7692
| 100mg | 46.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
