HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 150 products for "HIF/HIF Prolyl-Hydroxylase".
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HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Color and Shape:Odour SolidTAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formula:C111H188N42O24S2Purity:98%Color and Shape:SolidMolecular weight:2559.1HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormula:C26H24N2O3Purity:99.59%Color and Shape:White SolidMolecular weight:412.48ISM012-042
ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.Formula:C26H28N6O4Color and Shape:SolidMolecular weight:488.538HIF-1 α (556-574) (TFA)
HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].Purity:98%Color and Shape:Odour SolidHSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Formula:C20H39B12N4O2Color and Shape:SolidMolecular weight:499.41897Mersalyl
CAS:Mersalyl is an organic mercurial diuretic.Formula:C13H16HgNNaO6Color and Shape:SolidMolecular weight:505.854Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.67%Color and Shape:Yellow SolidMolecular weight:349.41Zifcasiran
CAS:Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.Formula:C737H972F20N211O349P43S8Color and Shape:SolidMolecular weight:20339.13HIF-1 inhibitor-5
HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1Formula:C28H35NO5Color and Shape:SolidMolecular weight:465.58Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purity:99.86%Color and Shape:White SolidMolecular weight:433.93Fibrostatin C
CAS:Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.Formula:C18H19NO8SColor and Shape:SolidMolecular weight:409.41ZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Formula:C15H14N2O2SColor and Shape:SolidMolecular weight:286.35HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formula:C21H19N3OSPurity:99.90% - >99.99%Color and Shape:White SolidMolecular weight:361.46Ref: TM-T61349
2mg85.00€5mg124.00€1mL*10mM (DMSO)133.00€10mg175.00€25mg293.00€50mg434.00€100mg622.00€1,4-DPCA ethyl ester
CAS:1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.Formula:C15H12N2O3Purity:99.54%Color and Shape:SolidMolecular weight:268.27Ref: TM-T36796
2mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg84.00€25mg145.00€50mg236.00€100mg400.00€200mg585.00€KG-548
CAS:KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.Formula:C9H4F6N4Purity:99.62%Color and Shape:SolidMolecular weight:282.15HIF-IN-1
CAS:HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Formula:C17H12N2OPurity:99.48%Color and Shape:Orange SolidMolecular weight:260.29ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Formula:C20H21N5O2Purity:99.8%Color and Shape:SolidMolecular weight:363.41N-Oxalylglycine
CAS:N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.Formula:C4H5NO5Purity:99.23%Color and Shape:SolidMolecular weight:147.09Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formula:C6H13NO5·H2SO4Purity:99.64%Color and Shape:SolidMolecular weight:277.25
