HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
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THS-044
CAS:62054-67-5
THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM …
Formula:
C11H12F3N3O3
Purity:
100%
Color and Shape:
Solid
Molecular weight:
291.23
Ref: TM-T13925
| 1mg | 79.00 € | ||
| 5mg | 151.00 € | ||
| 10mg | 235.00 € | ||
| 25mg | 384.00 € | ||
| 50mg | 546.00 € | ||
| 100mg | 737.00 € | ||
| 500mg | 1,486.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
AKB-6899
CAS:1007377-55-0
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form …
Formula:
C14H11FN2O4
Purity:
97.11%
Color and Shape:
Solid
Molecular weight:
290.25
Ref: TM-T29797
| 1mg | 74.00 € | ||
| 5mg | 167.00 € | ||
| 10mg | 259.00 € | ||
| 25mg | 450.00 € | ||
| 50mg | 645.00 € | ||
| 100mg | 907.00 € | ||
| 1mL*10mM (DMSO) | 177.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
HIF-2α-IN-9
CAS:2648334-36-3
HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of …
Formula:
C12H13F5O4S2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
380.35
Ref: TM-T78937
| 25mg | 1,688.00 € | ||
| 50mg | 2,225.00 € | ||
| 100mg | 2,897.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
HIF-2α-IN-1
CAS:1799948-06-3
HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.
Formula:
C16H8F5NO4S
Purity:
97.99%
Color and Shape:
Solid
Molecular weight:
405.3
Ref: TM-T15482
| 1mg | 97.00 € | ||
| 5mg | 232.00 € | ||
| 10mg | 378.00 € | ||
| 1mL*10mM (DMSO) | 256.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
PHD-IN-1
CAS:2924182-31-8
PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 …
Formula:
C24H23N7O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
441.49
Ref: TM-T79797
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
PHD-IN-2
CAS:2924182-42-1
PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, …
Formula:
C26H27N7O4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
501.54
Ref: TM-T79798
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
PHD2-IN-1
CAS:2768219-28-7
PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 …
Formula:
C21H23ClN4O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
446.88
Ref: TM-T79241
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
HIF-2α agonist 2
CAS:2750141-15-0
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for …
Formula:
C13H8Br2N2O2S
Purity:
98.32%
Color and Shape:
Soild
Molecular weight:
416.09
Ref: TM-T67831
| 1mg | 38.00 € | ||
| 5mg | 81.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 229.00 € | ||
| 50mg | 339.00 € | ||
| 100mg | 486.00 € | ||
| 200mg | 659.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
(Rac)-PT2399
CAS:1672662-07-5
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
Formula:
C17H10F5NO4S
Color and Shape:
Solid
Molecular weight:
419.32
Ref: TM-T12675
| 5mg | 325.00 € | ||
| 25mg | 916.00 € | ||
| 50mg | 1,273.00 € | ||
| 100mg | 2,050.00 € |
Estimated delivery in United States, on Tuesday 1 Apr 2025
AFP464 free base
CAS:468719-52-0
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent …
Formula:
C22H23F3N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
448.44
Ref: TM-T10258
| 25mg | 2,245.00 € | ||
| 50mg | 2,972.00 € | ||
| 100mg | 4,019.00 € |
Estimated delivery in United States, on Tuesday 1 Apr 2025
