HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 146 products of "HIF/HIF Prolyl-Hydroxylase"
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Adaptaquin
CAS:Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].Formula:C21H16ClN3O2Purity:99.75%Color and Shape:SolidMolecular weight:377.82TAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formula:C111H188N42O24S2Purity:98%Color and Shape:SolidMolecular weight:2559.1HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormula:C26H24N2O3Purity:99.59%Color and Shape:SolidMolecular weight:412.48IOX2-NH2-Methyl
<p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>Formula:C20H19N3O5Purity:97.64% - 99.31%Color and Shape:SolidMolecular weight:381.39Mersalyl
CAS:Mersalyl is an organic mercurial diuretic.Formula:C13H16HgNNaO6Color and Shape:SolidMolecular weight:505.854HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Formula:C20H39B12N4O2Molecular weight:499.41897Fibrostatin C
CAS:Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.Formula:C18H19NO8SColor and Shape:SolidMolecular weight:409.41Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.67%Color and Shape:SolidMolecular weight:349.41ZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Formula:C15H14N2O2SColor and Shape:SolidMolecular weight:286.35HIF-1α-IN-2 hydrochloride
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM inFormula:C21H20ClN3OSPurity:98%Color and Shape:SolidMolecular weight:397.92HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formula:C21H19N3OSPurity:99.90% - >99.99%Color and Shape:SolidMolecular weight:361.461,4-DPCA ethyl ester
CAS:1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.Formula:C15H12N2O3Purity:99.54%Color and Shape:SolidMolecular weight:268.27KG-548
CAS:KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.Formula:C9H4F6N4Purity:99.62%Color and Shape:SolidMolecular weight:282.15HIF-IN-1
CAS:HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Formula:C17H12N2OPurity:99.48%Color and Shape:SolidMolecular weight:260.29JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Formula:C12H6ClF3N4O3Purity:99.58% - ≥95%Color and Shape:SolidMolecular weight:346.65N-Oxalylglycine
CAS:N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.Formula:C4H5NO5Purity:99.23%Color and Shape:Colourless SolidMolecular weight:147.09FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Formula:C12H9ClN2O4Purity:97.1% - >99.99%Color and Shape:SolidMolecular weight:280.66Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formula:C6H13NO5·H2SO4Purity:99.64%Color and Shape:White CrystalMolecular weight:277.25ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Formula:C20H21N5O2Purity:99.8%Color and Shape:SolidMolecular weight:363.41Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Formula:C16H18O9Purity:98.84% - 99.67%Color and Shape:SolidMolecular weight:354.31
