Transporter

"SLC26A3-IN-1 inhibits SLC26A3, an anion transporter linked to diarrhea, with 340 nM IC50."

Cinromide (trans-3-Bromo-N-ethylcinnamamide) is used as a novel anticonvulsant agent.

LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.

Compound 12f, a DMT1 blocker, inhibits DMT1 with a 0.83 IC50, potentially blocking intestinal iron absorption.

Brilliant Yellow (Direct Yellow 4) is a potent and selective VGLUT inhibitor, a dye that is photodegradable.

Promazine hydrochloride, a phenothiazine less potent than chlorpromazine, treats disturbed behavior and nausea.

GPNA hydrochloride inhibits Gln transporter ASCT2, induces apoptosis in A549 cells, blocks SNAT1/2/4/5 & LAT1/2 transporters, and is a GGT substrate.

D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride), a constituent of striated muscle and liver, is used in the treatment of hyperlipoproteinemias.

MSNBA inhibits GLUT5 fructose uptake (KI: 3.2±0.4 μM) in MCF7 cells, serving as a potent GLUT5 probe.

EAAT2 activator2 (Compound 4(SF-2)) is a brain-penetrant modulator of excitatory amino acid transporter 2 (EAAT2) with a Ki of 28.7 nM. This compound enhances EAAT2-mediated glutamate uptake and improves synaptic glutamate clearance. EAAT2 activator2 holds potential for research into neurodegenerative diseases, such as amyotrophic lateral sclerosis and Alzheimer's disease.

GLUT inhibitor-1: oral, targets GLUT1/3 (IC50: 242/179 nM), for cancer/autoimmune research.

Membrane proteins are a class of proteins widely found in biological cell membranes, playing essential roles in the structure and function of cells. Based on their location and function, membrane proteins can be classified into three main categories: peripheral membrane proteins, integral membrane proteins, and lipid-anchored proteins. Membrane proteins encompass a variety of functional proteins, including glycoproteins, carrier proteins, and enzymes. They are often linked to carbohydrate molecules, which can transmit signals into the cell by undergoing structural changes, participating in signal transduction processes. Membrane proteins perform a range of critical functions, including substance transport, signal transduction, cell recognition, and energy conversion. In drug development, membrane proteins, especially G protein-coupled receptors (GPCRs), ion channels, and transporters, are of particular interest. Many diseases are related to the malfunction of specific membrane proteins. Therefore, drugs designed to target these proteins can regulate their activity, aiming to treat diseases. TargetMol has collected 6422 compounds that target membrane proteins, which can be used for membrane protein-related scientific research and drug screening, suitable for high-throughput and high-content screening.

Rapaglutin A is a glucose transporter (GLUT) inhibitor. It acts as a pan-GLUT inhibitor for the class I isomers GLUT1, GLUT3, and GLUT4, with an IC50 of 12 nM. Additionally, Rapaglutin A inhibits the proliferation of A549 cells.

WZB117-PPG is an inhibitor of glucose transporter 1 (GLUT1) with anticancer properties. Under visible light irradiation, this compound demonstrates significant photolytic efficiency and cytotoxicity toward cancer cells.

SW157765 is a glucose transporter GLUT8 inhibitor that inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitized cells.

AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).

Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.

L-Arginine (L-Arg) is a substrate of endothelial nitric oxide synthase (eNOS). High-Quality, Low-Cost!

Hemicholinium 3 is a potent and selective choline uptake blocker.

Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.

EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) is a thiopyridazine derivative that has been found to increase EAAT2 protein

BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.

Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.

TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.

α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.

BAY-876 is a selective and orally GLUT1 inhibitor. BAY-876 inhibits glycolytic metabolism and exhibits antitumor activity. Cost-effective and quality-assured.

Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).

CTPI-2 inhibits SLC25A1 (KD: 3.5 μM), glycolysis, PPARγ, GLUT4, has anti-tumor effects, and combats NASH and diet-induced obesity.

Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia.

KL-11743 blocks glucose metabolism, collapses NADH, and increases aspartate, shifting cells to oxidative phosphorylation.

Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.

WZB117 inhibits GLUT1; IC50 ~10μM slows A549 lung & MCF7 breast cancer cell growth.

DA-023 (Compound 4) acts as a selective positive allosteric modulator (PAM) of EAAT2, exhibiting an EC 50 value of 1 nM [1].

WAY-213613: Potent GLT-1/EAAT2 inhibitor (IC50: 85 nM), selective over EAAT1/EAAT3; inactive at glutamate receptors.

GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).

V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM

Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor

WAY-213613 hydrochloride: potent, selective GLT-1/EAAT2 inhibitor (IC50 85 nM); weaker for EAAT1/3; inactive at glutamate receptors; research tool for CNS.

DRB18 inhibits GLUT proteins, altering glucose metabolism and inducing cancer cell death by G1/S arrest and oxidative stress.

DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3.