Transporter

<p>Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON</p>

<p>D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride), a constituent of striated muscle and liver, is used in the treatment of hyperlipoproteinemias.</p>

<p>"SLC26A3-IN-1 inhibits SLC26A3, an anion transporter linked to diarrhea, with 340 nM IC50."</p>

<p>LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by &gt; 6 fold at concentrations &lt; 5 μM after 24 h.</p>

<p>Compound 12f, a DMT1 blocker, inhibits DMT1 with a 0.83 IC50, potentially blocking intestinal iron absorption.</p>

<p>GPNA hydrochloride inhibits Gln transporter ASCT2, induces apoptosis in A549 cells, blocks SNAT1/2/4/5 &amp; LAT1/2 transporters, and is a GGT substrate.</p>

<p>Promazine hydrochloride, a phenothiazine less potent than chlorpromazine, treats disturbed behavior and nausea.</p>

<p>Cinromide (trans-3-Bromo-N-ethylcinnamamide) is used as a novel anticonvulsant agent.</p>

<p>Brilliant Yellow (Direct Yellow 4) is a potent and selective VGLUT inhibitor, a dye that is photodegradable.</p>

<p>Membrane proteins are a class of proteins widely found in biological cell membranes, playing essential roles in the structure and function of cells. Based on their location and function, membrane proteins can be classified into three main categories: peripheral membrane proteins, integral membrane proteins, and lipid-anchored proteins. Membrane proteins encompass a variety of functional proteins, including glycoproteins, carrier proteins, and enzymes. They are often linked to carbohydrate molecules, which can transmit signals into the cell by undergoing structural changes, participating in signal transduction processes.<br><br>Membrane proteins perform a range of critical functions, including substance transport, signal transduction, cell recognition, and energy conversion. In drug development, membrane proteins, especially G protein-coupled receptors (GPCRs), ion channels, and transporters, are of particular interest. Many diseases are related to the malfunction of specific membrane proteins. Therefore, drugs designed to target these proteins can regulate their activity, aiming to treat diseases.<br><br>TargetMol has collected 6422 compounds that target membrane proteins, which can be used for membrane protein-related scientific research and drug screening, suitable for high-throughput and high-content screening.</p>

<p>GLUT inhibitor-1: oral, targets GLUT1/3 (IC50: 242/179 nM), for cancer/autoimmune research.</p>

<p>MSNBA inhibits GLUT5 fructose uptake (KI: 3.2±0.4 μM) in MCF7 cells, serving as a potent GLUT5 probe.</p>

<p>SW157765 is a glucose transporter GLUT8 inhibitor that inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitized cells.</p>

<p>Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).</p>

<p>CTPI-2 inhibits SLC25A1 (KD: 3.5 μM), glycolysis, PPARγ, GLUT4, has anti-tumor effects, and combats NASH and diet-induced obesity.</p>

<p>α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate</p>

<p>L-Arginine (L-Arg) is a substrate of endothelial nitric oxide synthase (eNOS). High-Quality, Low-Cost!</p>

<p>Hemicholinium 3 is a potent and selective choline uptake blocker.</p>

<p>Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia.</p>

<p>BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.</p>

<p>EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) is a thiopyridazine derivative that has been found to increase EAAT2 protein</p>

<p>Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.</p>

<p>Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.</p>

<p>Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.</p>

<p>Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.</p>

<p>KL-11743 blocks glucose metabolism, collapses NADH, and increases aspartate, shifting cells to oxidative phosphorylation.</p>

<p>UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.</p>

<p>AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).</p>

<p>Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.</p>

<p>Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,</p>

<p>BAY-876 is a selective and orally GLUT1 inhibitor. BAY-876 inhibits glycolytic metabolism and exhibits antitumor activity. Cost-effective and quality-assured.</p>

<p>STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.</p>

<p>Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.</p>

<p>TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.</p>

<p>WZB117 inhibits GLUT1; IC50 ~10μM slows A549 lung &amp; MCF7 breast cancer cell growth.</p>

<p>WAY-213613: Potent GLT-1/EAAT2 inhibitor (IC50: 85 nM), selective over EAAT1/EAAT3; inactive at glutamate receptors.</p>

<p>V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM</p>

<p>GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).</p>

<p>Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor</p>

<p>DRB18 inhibits GLUT proteins, altering glucose metabolism and inducing cancer cell death by G1/S arrest and oxidative stress.</p>

<p>WAY-213613 hydrochloride: potent, selective GLT-1/EAAT2 inhibitor (IC50 85 nM); weaker for EAAT1/3; inactive at glutamate receptors; research tool for CNS.</p>

<p>DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3.</p>