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NAMPT

NAMPT

Nicotinamide Phosphoribosyltransferase (NAMPT) is an enzyme involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme in cellular metabolism and energy production. NAMPT inhibitors are of interest in cancer research due to their ability to disrupt NAD+ metabolism and induce cell death in cancer cells. These inhibitors are also explored in the context of metabolic disorders and aging. At CymitQuimica, we offer NAMPT inhibitors to support your research in cancer biology, metabolism, and aging.

Found 36 products of "NAMPT"

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  • (E)-Daporinad
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    (E)-Daporinad

    CAS:
    <p>(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.</p>
    Formula:C24H29N3O2
    Purity:98.44% - >99.99%
    Color and Shape:Solid
    Molecular weight:391.51

    Ref: TM-T2644

  • Nampt-IN-9
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    Nampt-IN-9

    CAS:
    <p>Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.</p>
    Formula:C26H33N3O4
    Color and Shape:Solid
    Molecular weight:451.56

    Ref: TM-T62748

  • Nampt-IN-7
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    Nampt-IN-7

    CAS:
    <p>Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).</p>
    Formula:C20H21N5O3
    Color and Shape:Solid
    Molecular weight:379.41

    Ref: TM-T61597

  • Nampt activator-3
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    Nampt activator-3

    CAS:
    <p>NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.</p>
    Formula:C19H20N2O3
    Color and Shape:Solid
    Molecular weight:324.37

    Ref: TM-T72623

  • A-1293201
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    A-1293201

    CAS:
    <p>A-1293201 is a potent and selective NAMPT inhibitor.</p>
    Formula:C21H23N3O3
    Color and Shape:Solid
    Molecular weight:365.43

    Ref: TM-T70833

  • Teglarinad chloride
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    Teglarinad chloride

    CAS:
    <p>Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.</p>
    Formula:C30H43Cl2N5O8
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:672.6

    Ref: TM-T26254

  • LB-60-OF61
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    LB-60-OF61

    CAS:
    <p>LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.</p>
    Formula:C29H30N6O2
    Purity:99.47%
    Color and Shape:Solid
    Molecular weight:494.59

    Ref: TM-T11823

  • JGB-1-155
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    JGB-1-155

    CAS:
    <p>JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].</p>
    Formula:C26H38N2O3
    Color and Shape:Solid
    Molecular weight:426.59

    Ref: TM-T86767

  • Nampt-IN-10 TFA
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    Nampt-IN-10 TFA

    CAS:
    <p>Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.</p>
    Formula:C29H29F4N5O4
    Color and Shape:Solid
    Molecular weight:587.21557

    Ref: TM-T64273

  • GNE-618
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    GNE-618

    CAS:
    <p>GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).</p>
    Formula:C21H15F3N4O3S
    Color and Shape:Solid
    Molecular weight:460.43

    Ref: TM-T15403

  • NAMPT activator-6
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    NAMPT activator-6

    CAS:
    <p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>
    Formula:C17H21N5O3S
    Color and Shape:Solid
    Molecular weight:375.45

    Ref: TM-T86958

  • Nampt activator-4
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    Nampt activator-4

    CAS:
    <p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>
    Formula:C26H22F3N7OS
    Color and Shape:Solid
    Molecular weight:537.56

    Ref: TM-T86957

  • CB30865
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    CB30865

    CAS:
    <p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>
    Formula:C26H22BrN5O2
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:516.39

    Ref: TM-T14882

  • Nampt-IN-15
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    Nampt-IN-15

    CAS:
    <p>Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.</p>
    Formula:C24H30N4O2
    Color and Shape:Solid
    Molecular weight:406.52

    Ref: TM-T201167

  • Nampt-IN-13
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    Nampt-IN-13

    CAS:
    <p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>
    Formula:C24H30N6O2
    Color and Shape:Solid
    Molecular weight:434.53

    Ref: TM-T201106

  • Nampt-IN-14
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    Nampt-IN-14

    CAS:
    <p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>
    Formula:C33H35N7O2
    Color and Shape:Solid
    Molecular weight:561.68

    Ref: TM-T201172