PPAR
Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes involved in metabolism, particularly fatty acid storage and glucose metabolism. PPAR inhibitors are important tools for studying metabolic disorders such as diabetes, obesity, and cardiovascular diseases. These inhibitors can modulate lipid metabolism, insulin sensitivity, and inflammation, making them valuable in therapeutic research. At CymitQuimica, we offer a range of PPAR inhibitors to support your research in metabolic diseases, endocrinology, and drug development.
Found 170 products of "PPAR"
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Mifobate
CAS:Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。Formula:C11H17ClO7P2Purity:99.12%Color and Shape:SolidMolecular weight:358.65Fenofibrate
CAS:Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.Formula:C20H21ClO4Purity:99.13% - 99.95%Color and Shape:Crystals From Isopropanol SolidMolecular weight:360.83NSC-87877
CAS:NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.Formula:C19H13N3O7S2Purity:97.35%Color and Shape:SolidMolecular weight:459.45Clofibric acid
CAS:Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.Formula:C10H11ClO3Purity:99.47% - 99.8%Color and Shape:Pale Yellow SolidMolecular weight:214.65EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Formula:C28H35NO3Purity:98.36%Color and Shape:SolidMolecular weight:433.58Ref: TM-T13289
1mg107.00€5mg227.00€10mg378.00€25mg620.00€50mg868.00€100mg1,169.00€1mL*10mM (DMSO)250.00€Retinoic acid
CAS:Retinoic acid (Tretinoin) binds to and activates RARs, thereby inducing changes in gene expression that lead to inhibition of tumorigenesis.Formula:C20H28O2Purity:97.21% - 99.60%Color and Shape:Yellow-Orange PowderMolecular weight:300.44MA-0204
CAS:MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human,Formula:C25H27F3N2O4Purity:97.8%Color and Shape:SolidMolecular weight:476.49Ref: TM-T15945
1mg96.00€5mg178.00€10mg301.00€25mg490.00€50mg677.00€100mg900.00€200mg1,206.00€1mL*10mM (DMSO)187.00€Fenofibric acid
CAS:Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.Formula:C17H15ClO4Purity:99.36%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:318.75Bezafibrate
CAS:Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.Formula:C19H20ClNO4Purity:99.56% - 99.82%Color and Shape:SolidMolecular weight:361.82Anandamide
CAS:Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but alsoFormula:C22H37NO2Purity:95.037% - 99.22%Color and Shape:Light Yellow OilMolecular weight:347.53Ref: TM-T14046
1mg34.00€2mg46.00€5mg67.00€10mg117.00€25mg221.00€50mg330.00€100mg485.00€200mg675.00€1mL*10mM (DMSO)73.00€Candesartan
CAS:Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.Formula:C24H20N6O3Purity:98.3% - 99.55%Color and Shape:Colorless Solid CrystallineMolecular weight:440.47Muraglitazar
CAS:Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.Formula:C29H28N2O7Purity:99.17%Color and Shape:SolidMolecular weight:516.54Oleoylethanolamide
CAS:Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.Formula:C20H39NO2Purity:99.98%Color and Shape:SolidMolecular weight:325.53Ref: TM-T12296
2mg34.00€5mg50.00€10mg75.00€25mg138.00€50mg236.00€100mg356.00€200mg522.00€1mL*10mM (DMSO)55.00€Pioglitazone hydrochloride
CAS:Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplasticFormula:C19H20N2O3S·HClPurity:99.64% - >99.99%Color and Shape:White Crystals Or Crystalline PowderMolecular weight:392.90Cloxiquine
CAS:Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.Formula:C9H6ClNOPurity:99.82% - 99.87%Color and Shape:Light Yellow CrystalsMolecular weight:179.6β-Amyrone
CAS:beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM.Formula:C30H48OPurity:99.55%Color and Shape:SolidMolecular weight:424.75-Aminosalicylic Acid
CAS:5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!Formula:C7H7NO3Purity:98.88% - 99.49%Color and Shape:Purplish-Tan Solid PowderMolecular weight:153.14Pioglitazone
CAS:Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!Formula:C19H20N2O3SPurity:95% - 99.57%Color and Shape:White PowderMolecular weight:356.44LY518674
CAS:LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.Formula:C23H27N3O4Purity:98.87%Color and Shape:SolidMolecular weight:409.48Ref: TM-T15821
1mg167.00€5mg340.00€10mg505.00€25mg802.00€50mg1,099.00€100mg1,485.00€1mL*10mM (DMSO)376.00€NTP42
CAS:NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)Formula:C25H23F2N3O5SPurity:97.55%Color and Shape:SolidMolecular weight:515.53Ref: TM-T12268
1mg59.00€2mg86.00€5mg133.00€10mg203.00€25mg344.00€50mg512.00€100mg735.00€1mL*10mM (DMSO)150.00€GW7647
CAS:GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.Formula:C29H46N2O3SPurity:99.3% - 99.34%Color and Shape:SolidMolecular weight:502.75Gemfibrozil
CAS:Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.Formula:C15H22O3Purity:99.53% - 99.88%Color and Shape:Crystals From Hexane SolidMolecular weight:250.33Rosiglitazone maleate
CAS:Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.Formula:C22H23N3O7SPurity:99.33% - 99.51%Color and Shape:Off-White SolidMolecular weight:473.50Daidzein
CAS:Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein.Formula:C15H10O4Purity:98.08%Color and Shape:SolidMolecular weight:254.24Magnolol
CAS:Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.Formula:C18H18O2Purity:99.49% - 99.98%Color and Shape:A Bioactive Compound Found In The Bark Of The Houpu MagnoliaMolecular weight:266.33MK-0533
CAS:MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.
Formula:C28H24F3NO6Purity:99.03%Color and Shape:SoildMolecular weight:527.49Arhalofenate
CAS:Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.Formula:C19H17ClF3NO4Purity:98.97%Color and Shape:SolidMolecular weight:415.79Ref: TM-T16022
1mg62.00€5mg205.00€10mg359.00€25mg588.00€50mg825.00€100mg1,111.00€200mg1,501.00€1mL*10mM (DMSO)270.00€Sulotroban potassium
Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.Formula:C16H16KNO5SPurity:98.02%Color and Shape:SoildMolecular weight:373.46Mavodelpar free acid hydrochloride
Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.
Formula:C31H31ClFNO5Purity:98.13%Color and Shape:SoildMolecular weight:552.03PPARγ agonist 16
CAS:PPARγ agonist16 (Compound 4G) is a PPARγ agonist that competitively binds to the ligand-binding domain (LBD) of PPARγ with an IC50 of 1790 nM. It reduces ear swelling in mouse models and exhibits antihyperglycemic activity in mice with Streptozotocin-induced diabetes.Formula:C19H14BrNO4SColor and Shape:SolidMolecular weight:432.29Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
CAS:Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.Formula:C24H23NO5SPurity:99.59%Color and Shape:SoildMolecular weight:437.51Ref: TM-T63898
1mg175.00€5mg404.00€10mg593.00€25mg888.00€50mg1,251.00€100mg1,693.00€1mL*10mM (DMSO)447.00€PPARγ agonist 15
PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.Formula:C21H16N4O3S2Color and Shape:SolidMolecular weight:436.51Nuclear Receptor Compound Library
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;
Color and Shape:Odour SolidWAY-620472
CAS:WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.Formula:C23H21N5OSPurity:98.99%Color and Shape:SolidMolecular weight:415.51GQ-16
CAS:GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.Formula:C19H16BrNO3SPurity:99.84%Color and Shape:SolidMolecular weight:418.3Ref: TM-T21955
10mg39.00€25mg80.00€50mg116.00€100mg187.00€200mg280.00€500mg449.00€1mL*10mM (DMSO)35.00€PPAR agonist 6
PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].Color and Shape:Odour SolidGW590735
CAS:GW590735: PPARα agonist, EC50=4 nM, >500x selective over PPARδ/γ, for dyslipidemia research.Formula:C23H21F3N2O4SPurity:99.53%Color and Shape:SolidMolecular weight:478.48E0924G
CAS:E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.Formula:C12H12N2O3Color and Shape:SolidMolecular weight:232.24MCC-555
CAS:MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.Formula:C21H16FNO3SPurity:99.07% - 99.82%Color and Shape:SolidMolecular weight:381.42Ref: TM-T21764
5mg66.00€10mg105.00€25mg215.00€50mg356.00€100mg530.00€500mg1,153.00€1mL*10mM (DMSO)73.00€PPARγ-IN-3
PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.Formula:C23H28FN7O3Color and Shape:SolidMolecular weight:469.51Anti-obesity agent 1
Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.
Formula:C21H22N2O6Color and Shape:SolidMolecular weight:398.409CUDA
CAS:CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.
Formula:C19H36N2O3Purity:97.585%Color and Shape:SolidMolecular weight:340.5CC618
CAS:CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.Formula:C20H15F6N3O3S2Purity:99.94%Color and Shape:SolidMolecular weight:523.47Ref: TM-T9767
1mg109.00€5mg235.00€10mg349.00€25mg532.00€50mg745.00€100mg999.00€200mg1,333.00€1mL*10mM (DMSO)298.00€AZD-9574
CAS:AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.Formula:C21H22F2N6O2Purity:98.46% - 99.39%Color and Shape:SolidMolecular weight:428.44Sulotroban
CAS:sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.Formula:C16H17NO5SPurity:98.86% - 99.98%Color and Shape:SolidMolecular weight:335.378-iso Prostaglandin F1β
CAS:8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.Formula:C20H36O5Color and Shape:SolidMolecular weight:356.5Anti-osteoporosis agent-10
Anti-osteoporosis agent-10 is an inhibitor of osteoporosis that suppresses the formation of osteoclasts with an IC50 of 0.042 μM. It also exhibits antagonistic activity towards PPARγ, with an EC50 value of 0.75 μM.Color and Shape:Odour SolidLipid Metabolism Compound Library
A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).
Color and Shape:Odour Solid8-iso Prostaglandin F1α
CAS:8-iso Prostaglandin F1α induces vasoconstrictor effects in (PA),(PV) and (MA) through activation of TXA2R, tyrosine kinases and Rho kinases.Formula:C20H36O5Color and Shape:SolidMolecular weight:356.5(±)-CBCQ
CAS:(±)-CBCQ, an oxidation product of cannabidiol, exhibits an EC50 value of 14.7 μM for the activation of peroxisome proliferator-activated receptor γ (PPAR-γ).Formula:C21H28O3Color and Shape:SolidMolecular weight:328.45
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