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Phospholipase

Phospholipase

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic substances, playing a critical role in membrane biology and the generation of signaling molecules. Inhibitors of phospholipases are used to study their role in inflammatory diseases, cardiovascular disorders, and neurodegeneration. These inhibitors are also valuable in exploring lipid signaling pathways and their implications in disease mechanisms. At CymitQuimica, we provide a variety of phospholipase inhibitors to support your research in inflammation, lipid metabolism, and cell signaling.

Found 82 products of "Phospholipase"

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  • 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
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    2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide

    CAS:
    <p>2-Decenoylaminoethyl cyclohexylethyl sulfide prevents stress ulcers, stabilizes phospholipase A2 and prostaglandin E2.</p>
    Formula:C20H37NOS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:339.58

    Ref: TM-T13488

  • ML299
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    ML299

    CAS:
    <p>ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).</p>
    Formula:C23H26BrFN4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:489.38

    Ref: TM-T8968

  • Lp-PLA2-IN-3
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    Lp-PLA2-IN-3

    CAS:
    <p>Lp-PLA2-IN-3: Potent oral inhibitor of human Lp-PLA2 with a 14 nM IC50.</p>
    Formula:C20H13ClF3N3O3S
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:467.85

    Ref: TM-T11874

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    ASM-IN-1

    CAS:
    <p>ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.</p>
    Formula:C16H12BrN3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:390.19

    Ref: TM-T74778

  • GK187
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    GK187

    CAS:
    <p>GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.</p>
    Formula:C14H15F5O2
    Color and Shape:Solid
    Molecular weight:310.26

    Ref: TM-T37221

  • Halopemide
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    Halopemide

    CAS:
    <p>Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2).</p>
    Formula:C21H22ClFN4O2
    Purity:96.57%
    Color and Shape:Solid
    Molecular weight:416.88

    Ref: TM-T15461

  • Giripladib
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    Giripladib

    CAS:
    <p>Giripladib (PLA695/PLX-695) blocks radiation-boosted phosphorylation of ERK and Akt in endothelial cells.</p>
    Formula:C41H36ClF3N2O4S
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:745.25

    Ref: TM-T31929

  • VU0155069
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    VU0155069

    CAS:
    <p>VU0155069, a selective PLD1 inhibitor (IC50: 46 nM), halts cancer cell migration in transwell assays.</p>
    Formula:C26H27ClN4O2
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:462.97

    Ref: TM-T17239

  • VU0364739
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    VU0364739

    CAS:
    <p>VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].</p>
    Formula:C26H27FN4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:446.52

    Ref: TM-T78161

  • Lp-PLA2-IN-13
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    Lp-PLA2-IN-13

    CAS:
    <p>Lp-PLA2-IN-13 (compound 15), a potent Lp-PLA2 inhibitor, holds potential for research in neurodegenerative-related diseases [1].</p>
    Formula:C22H17F5N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:496.39

    Ref: TM-T79073

  • Lp-PLA2-IN-2
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    Lp-PLA2-IN-2

    CAS:
    <p>Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.</p>
    Formula:C19H23FN2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:394.46

    Ref: TM-T11873

  • Lp-PLA2-IN-14
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    Lp-PLA2-IN-14

    CAS:
    <p>Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.</p>
    Formula:C16H14F3N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:353.3

    Ref: TM-T79074

  • 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
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    7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid

    CAS:
    <p>7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA, 5 μM) significantly impacts the response to βA(25-35) stimulation. It reduces the formation of ROS.</p>
    Formula:C22H40O2
    Color and Shape:Solid
    Molecular weight:336.55

    Ref: TM-T88483

  • Varespladib methyl
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    Varespladib methyl

    CAS:
    <p>Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.</p>
    Formula:C22H22N2O5
    Purity:99.42% - 99.97%
    Color and Shape:Solid
    Molecular weight:394.42

    Ref: TM-T17218

  • Ecopladib
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    Ecopladib

    CAS:
    <p>Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) &amp; 0.11 μM (rat blood).</p>
    Formula:C39H33Cl3N2O5S
    Purity:95.15%
    Color and Shape:Solid
    Molecular weight:748.11

    Ref: TM-T11149

  • Rilapladib
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    Rilapladib

    CAS:
    <p>Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activating</p>
    Formula:C40H38F5N3O3S
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:735.8

    Ref: TM-T16751

  • MAFP
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    MAFP

    CAS:
    <p>MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.</p>
    Formula:C21H36FO2P
    Color and Shape:Solid
    Molecular weight:370.48

    Ref: TM-T15948

  • GK420
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    GK420

    CAS:
    <p>GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.</p>
    Formula:C20H25NO5S
    Color and Shape:Solid
    Molecular weight:391.481

    Ref: TM-T204352

  • Ro 23-9358
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    Ro 23-9358

    CAS:
    <p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>
    Formula:C30H51NO6
    Color and Shape:Solid
    Molecular weight:521.729

    Ref: TM-T204941

  • Lp-PLA2-IN-16
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    Lp-PLA2-IN-16

    CAS:
    <p>Lp-PLA2-IN-16 (Example 1) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential applications in Alzheimer's disease research [1].</p>
    Formula:C22H17F5N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:480.39

    Ref: TM-T79076

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