Microbiology/Virology

<p>Antituberculosis Agent-1 (Compound 8a) is an effective antituberculosis agent, demonstrating a minimum inhibitory concentration (MIC) of 3.84 μg/mL against</p>

<p>Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.</p>

<p>SLU-10482, an antiparasitic agent, effectively reduces C.</p>

<p>Sulfisoxazole acetyl (Gantrisin) is an agent with antibacterial activity.</p>

<p>Glycolithocholic acid 3-sulfate (disodium) demonstrates inhibitory effects on in vitro HIV-1 replication and has potential applications in HIV infection and</p>

<p>NCI-B16 is a small-molecule RNA binder that inhibits HCV (hepatitis C virus) replication [1].</p>

<p>Beta-gal-nonoate, a β-galactosidase dependent nitric oxide (NO) donor, releases NO upon activation by β-galactosidase. It exhibits bactericidal activity, thus serving as an effective bactericide [1].</p>

<p>AS-2077715, an antifungal agent, exhibits inhibitory activity against Trichophyton species and is derived from the fermentation broth of Capnodium sp. 339855. It is utilized in the study of fungal infections [1].</p>

<p>Daldinone A (Compound 4), isolated from Nigrospora oryzae, exhibits antibacterial properties, specifically demonstrating antimicrobial potential against P. aeruginosa [1].</p>

<p>EDI048, also known as compound 1.16, is an orally active inhibitor of Cryptosporidium PI4K, utilized in the study of cryptosporidiosis [1].</p>

<p>Oxynitidine, an HBV inhibitor (ID50 = 30.8 µg/mL), effectively suppresses HBV DNA replication and may be utilized in viral infection research [1].</p>

<p>Tobevibart, an IgG1-lambda humanized monoclonal antibody targeting the hepatitis B virus (HBV) surface envelope protein, exhibits antiviral activity [1].</p>

<p>Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci,</p>

<p>Pyrethrin II, an active insecticidal component of pyrethrins, is a biogenic insecticide derived from Chrysanthemum cinerariifolium [1].</p>

<p>Zndm19 is an inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1), utilized in researching drug-resistant bacterial infections [1].</p>

<p>FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.</p>

<p>HBV-IN-6 is a potent inhibitor of HBV (EC50: 287.9 nM).</p>

<p>Variculanol, a compound with antimicrobial, anticancer, and anti-HCV NS3/4A protease properties, is derived from the marine fungus Aspergillus versicolor [1].</p>

<p>Talviraline (HBY 097) inhibits HIV-1 replication and reduces cell death in various cells and immune cells.</p>

<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>

<p>Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).</p>

<p>Mtb-IN-4 (compound 17h) is a non-toxic isoxazole that exhibits anti-Mycobacterium tuberculosis (Mtb) activity, with an IC50 value of 0.70 μM.</p>

<p>Laninamivir Octanoate Monohydrate is a neuraminidase inhibitor.</p>

<p>GSK3839919A is a potent allosteric inhibitor of HIV-1 integrase [1].</p>

<p>1,8-Dichloroanthraquinone, a derivative of anthraquinone, effectively inhibits sulfide production in sulfate-reducing bacteria [1].</p>

<p>Y18501, an oxysterol-binding protein (OSBPI) inhibitor structurally akin to Oxathiapiprolin, demonstrates potent inhibition against Phytophthora spp.</p>

<p>Tuberculosis inhibitor 6 (compound 2c), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, is highly active against Mycobacterium tuberculosis (MIC 90 of</p>

<p>U 89360E is a peptidic inhibitor.</p>

<p>ThrRS-IN-3: Potent inhibitor of Salmonella enterica ThrRS, IC50 = 19 nM, Kd = 34 nM, with antibacterial effects.</p>

<p>Oxamniquine is an effective compound for the treatment of schistosomiasis.</p>

<p>ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.</p>

<p>Indinavir, threo- is a protease inhibitor utilized as a component of highly active antiretroviral treatment to HIV/AIDS.</p>

<p>CPFX2090, a cephalosporin antibacterial compound.</p>

<p>Streptovitacin A boosts growth inhibition against fungi.</p>

<p>AU1235 is a Mycobacterium tuberculosis inhibitor.</p>

<p>JTK-853: novel non-nucleoside HCV polymerase inhibitor with strong antiviral activity (EC50: 0.38 μM genotype 1a, 0.035 μM 1b).</p>

<p>Anti-Trypanosoma cruzi agent-3 is an antiprotozoal agent.</p>

<p>Compound 158 (6c), a Micrococcin analogue, serves as an antibacterial agent effective against impetigo and Clostridium difficile infection (CDI) [1].</p>

<p>Micronomicin (Gentamicin C2b) is an antibiotic exhibiting antibacterial and bactericidal capacity.</p>

<p>Zika virus-IN-1 is an inhibitor of Zika virus (EC50: 1.56 μM).</p>

<p>JNJ4796 is an oral fusion inhibitor that neutralizes influenza A group 1 by blocking HA-mediated fusion, mimicking bnAbs.</p>

<p>Galidesivir inhibits RdRP; has broad antiviral effects on various RNA viruses; effective against Ebola, Marburg in animals.</p>

<p>BILR-355 is a reverse transcriptase inhibitor.</p>

<p>S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.</p>

<p>Pradimicin A derivative 26 exhibits antifungal, antiviral, and antiparasitic properties by attaching to d-mannose (Man)-rich glycans in pathogenic organisms [1</p>

<p>Tuberculosis inhibitor 8 (compound 3b), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, exhibits potent activity against both Mycobacterium</p>

<p>Valtorcitabine dihydrochloride, a DNA polymerase inhibitor, is used potentially for the treatment of HBV infection.</p>

<p>Kynostatin-272 is a HIV protease inhibitor. KNI-272 blocked the maturation of viral particles.</p>

<p>HCoV-OC43-IN-1 (Compound IV-16) serves as an inhibitor of the coronavirus HCoV-OC43, exhibiting antiviral efficacy with an EC50 of 90 nM.</p>

<p>Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease.</p>