Microbiology/Virology

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.

Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.

Oxacillin sodium salt (Oxabel) is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.

Nifursemizone (Etafurazone) is an agent with antiprotozoal.

Zidebactam (WCK-5107) is an effective β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 inhibitor (IC50: 0.26 μg/mL).

Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.

Sodium montmorillonite (Bentolite) can catalyze reactions of the 5'-phosphorimidazolide of adenosine used as a model generated RNA type oligomers.

Tioxazafen is a disubstituted oxadiazole, and is a broad-spectrum seed treatment nematicide.

Embeconazole (R 120758) is a triazole antifungal agent with strong in vitro activity against clinically important fungi such as Candida and Aspergillus.

Motavizumab (MEDI-524) is a neutralizing antibody against RSV, altering the cytokine response induced by RSV in a mouse model.

Antifungal 1-(4-AMinophenyl)-2(1h)-pyridinone inhibits Candida, Aspergillus, Pseudomonas, and Staphylococcus.

Sch 29482 is a penem antibiotic.

Tubulysin Aintermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A. Tubulysin A (TubA) acts as an antibiotic (antibiotic), anti-microtubule toxins (anti-microtubule toxins), and apoptosis (apoptosis) inducer, which can be isolated from myxobacteria. It exhibits anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative properties, effectively blocking cells in the G2/M phase, inhibiting tubulin polymerization, and inducing depolymerization of isolated microtubules. Tubulysin A serves as an ADC Cytotoxin (ADC Cytotoxin) in the synthesis of ADCs.

Amoxicillin, L- is an antibiotic. It is also useful for the treatment of a number of bacterial infections.

EBVEBNA3B (416-424) is an HLA-A11-restricted antigenic peptide derived from the EBVEBNA3B protein.

Plazomicin, an advanced antibiotic, resists aminoglycoside enzymes, is highly active against Enterobacteriaceae.

CK 492B is a bio-active chemical.

α-Guaiene, a sesquiterpene identified in P. cablin, showcases its presence within this species.

4-Nitrosodiphenylamine exhibits significant antibacterial activity, with an EC50 value of 5.715 mg/L against [Erwinia amylovora].

Hp1404 is a novel cationic antimicrobial peptide with specific inhibitory activity against Gram-positive bacteria, including Laburnetin-resistant Staphylococcus aureus (MRSA). Its antibacterial properties, low toxicity, and low likelihood of inducing resistance make it a useful candidate for antimicrobial agent research.

L 693989 is a pneumocandin.

Rubrosulphin is a toxic metabolite found in a number of fungi.

Cytochalasin A, a cell-penetrating fungal toxin, blocks HIV-1 protease (IC50 = 3 μM) and hinders actin and microtubule assembly. It's an antibiotic.

Tetromycin B was isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides.

Chinfloxacin, a quinolone antibiotic, is used potentially for the treatment of bacterial infections.

Levonadifloxacin, a broad-spectrum fluoroquinolone antibiotic, is used potentially for the treatment of staphylococci.

Lynronne-3, an antimicrobial peptide, demonstrates activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimum

4-(2-Octylamino)diphenylamine is an aromatic amine antioxidant known to be toxic to V. fischeri, with an IC50 value of 0.68 mg/mL. It induces skin sensitization and contact dermatitis in the murine local lymph node assay and can be used as a rubber additive.

Propionylmaridomycin is a macrolide antibiotic.

NUDT5/14 antagonist 1 (Compound 9) is a dual selective antagonist for nucleotide diphosphate kinases NUDT5 and NUDT14, exhibiting IC50 values of 0.27 and 0.16 μM, respectively. Additionally, NUDT5/14 antagonist 1 binds to Bruton's tyrosine kinase (BTK) with an IC50 of 0.377 μM.

WJM280 is an orally active antimalarial compound with an EC50 of 0.04 μM against the parasite P. falciparum 3D7.

HIVgp120 (318-327) is a short sequence (rgpgrafvti) from the envelope peptide of the HIV-1 IIIB strain, corresponding to the conserved C-terminal region of the glycoprotein. It is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIVgp120 (318-327) lacks the A2 anchor residues needed for epitope-specific CTL recognition but possesses structural features that allow mixed A2 binding.

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

FITC-labeled TAT (47-57) peptide enhances protein yields & solubility; TAT is a CPP.

Antimycobacterial agent-10 (compound 5) is an inhibitor of DNA gyrase with an IC50 of 96 nM against Mycobacterium tuberculosis gyrase, demonstrating antibacterial properties.

BO-1, a benzoate ester, exhibits antibacterial properties, effectively inhibiting multidrug-resistant Staphylococcus aureus.

Restricticin is used as a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities.

ddATP (lithium) (2',3'-Dideoxyadenosine 5'-triphosphate (lithium)) is an active metabolite of 2',3'-dideoxyinosine and acts as a chain extension inhibitor of DNA polymerase. It is employed in DNA sequencing using the Sanger method and is also used in studies related to viral infections.

AAK1-IN-6 is an inhibitor of AP-2 associated protein kinase 1 (AAK1, IC50 = 12 nM) and exhibits antiviral activity against Dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 is applicable in antiviral research.

Antifungalagent 88 exhibits antifungal activity, with a MIC value ranging from <0.125 μg/mL to 1 μg/mL.

NSC65847 is a novel dual inhibitor of viral and Streptococcus pneumoniae neuraminidase.

apo-Enterobactin is a derivative of Enterobactin, which is a bacterial iron carrier that facilitates iron absorption.

AR ligand-30 serves as the target protein ligand for PROTAC Bavdegalutamide, utilized in prostate cancer research.

Sannamycin B is a bioactive chemical.

Terrecyclic acid, a sesquiterpene from A. terreus, has antibiotic, anticancer properties, and affects S. aureus, B. subtilis, M. roseus.

Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir.

Nocardicin A, a moderate antibiotic agent, shows inhibitory for a wild spectrum of gram-negative bacteria.

3-hydroxy Myristic acid methyl ester found in Eucalyptus, combats M. tuberculosis, non-toxic to Vero cells, and in wild strawberry aroma, not in cultivated.