GlyT
Glycine Transporter (GlyT) inhibitors are compounds that block the reuptake of glycine, an important inhibitory neurotransmitter in the spinal cord and brainstem. By inhibiting glycine transporters, these compounds increase the availability of glycine in the synaptic cleft, enhancing its inhibitory effects on neuronal activity. GlyT inhibitors are of interest for their potential therapeutic applications in conditions like chronic pain, spasticity, and schizophrenia. At CymitQuimica, we provide GlyT inhibitors to support your research in pain management, motor control, and neuropsychiatric disorders.
Found 26 products of "GlyT"
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LY2365109 hydrochloride
CAS:LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.Formula:C22H28ClNO5Purity:98.27%Color and Shape:SolidMolecular weight:421.91Ref: TM-T11908
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg235.00€50mg354.00€100mg512.00€1mL*10mM (DMSO)87.00€8-hydroxy Amoxapine
CAS:8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2
Formula:C17H16ClN3O2Color and Shape:SolidMolecular weight:329.78DCCCyb
CAS:DCCCyb: oral GlyT1 inhibitor with high in vivo occupancy in rhesus monkeys, confirmed by PET tracer displacement.Formula:C22H29Cl2NO3SPurity:98%Color and Shape:SolidMolecular weight:458.44Org 24598 lithium salt
CAS:Org 24598 lithium salt is a GlyT-1 inhibitor of glycine transporter 1.Formula:C19H19F3LiNO3Color and Shape:SolidMolecular weight:373.3(Rac)-Oleoylcarnitine
CAS:(Rac)-Oleoylcarnitine, an endogenous acylcarnitine, acts as a potential non-competitive inhibitor of glycine transporter 2 (GLYT2) and can be used as a pain suppressant.Formula:C25H47NO4Molecular weight:425.65SSR504734 HCl
CAS:SSR504734 inhibits GlyT1 in humans, rats, mice (IC50=18, 15, 38 nM); treats schizophrenia, anxiety, depression orally.
Formula:C20H21Cl2F3N2OPurity:98.05% - 99.93%Color and Shape:SolidMolecular weight:433.30Bitopertin
CAS:Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nMFormula:C21H20F7N3O4SPurity:98.57% - 98.71%Color and Shape:SolidMolecular weight:543.46SSR504734
CAS:SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.Formula:C20H20ClF3N2OColor and Shape:SolidMolecular weight:396.83Org 25543 hydrochloride
CAS:Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2).Formula:C24H33ClN2O4Purity:99.26%Color and Shape:SolidMolecular weight:448.983Opiranserin hydrochloride
CAS:Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μMFormula:C21H35ClN2O5Purity:99.33%Color and Shape:SolidMolecular weight:430.97Ref: TM-T9833
1mg90.00€5mg215.00€10mg340.00€25mg618.00€50mg879.00€100mg1,224.00€500mg2,457.00€1mL*10mM (DMSO)236.00€Sarcosine
CAS:Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.Formula:C3H7NO2Purity:99.90%Color and Shape:Deliquescent Water Soluble Physical Description Deliquescent Crystals Or Powder Has A Sweetish Taste (Ntp 1992)Molecular weight:89.09MPDC
CAS:MPDC acts as a competitive inhibitor against the Na+-dependent high-affinity glutamate transporter within forebrain synaptosomes.Formula:C7H9NO4Purity:98%Color and Shape:SolidMolecular weight:171.15Org-25935
CAS:Org-25935, a GlyT-1 inhibitor, is used potentially for the treatment of schizophrenia and alcohol dependence.Formula:C21H26ClNO3Color and Shape:SolidMolecular weight:375.89NFPS
CAS:NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.Formula:C24H24FNO3Purity:98%Color and Shape:SolidMolecular weight:393.45PF-03463275 2HCl
CAS:PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, a GlyT1 glycine transporter.Formula:C19H24Cl3FN4OPurity:98%Color and Shape:SolidMolecular weight:449.78Bitopertin (R enantiomer)
CAS:Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin.Formula:C21H20F7N3O4SPurity:98%Color and Shape:SolidMolecular weight:543.46GSK931145
CAS:GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain.Formula:C23H30N2OPurity:98%Color and Shape:SolidMolecular weight:350.5Org 24598
CAS:Potent GlyT1b inhibitor, IC50 = 6.9 nM; little effect on GlyT-2, adrenoceptors, dopamine, 5HT receptors, GABA transporters.Formula:C19H20F3NO3Color and Shape:SolidMolecular weight:367.36Tilapertin
CAS:Tilapertin is an oral glycine transporter type-1 inhibitor.Formula:C20H21F3N2O2Purity:98%Color and Shape:SolidMolecular weight:378.39Opiranserin
CAS:Opiranserin is a development as an injectable agent for the treatment of postoperative pain.Formula:C21H34N2O5Purity:98%Color and Shape:SolidMolecular weight:394.51
