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GlyT

GlyT

Glycine Transporter (GlyT) inhibitors are compounds that block the reuptake of glycine, an important inhibitory neurotransmitter in the spinal cord and brainstem. By inhibiting glycine transporters, these compounds increase the availability of glycine in the synaptic cleft, enhancing its inhibitory effects on neuronal activity. GlyT inhibitors are of interest for their potential therapeutic applications in conditions like chronic pain, spasticity, and schizophrenia. At CymitQuimica, we provide GlyT inhibitors to support your research in pain management, motor control, and neuropsychiatric disorders.

Found 26 products of "GlyT"

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  • LY2365109 hydrochloride
    Targetmol
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    LY2365109 hydrochloride

    CAS:
    <p>LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.</p>
    Formula:C22H28ClNO5
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:421.91

    Ref: TM-T11908

  • 8-hydroxy Amoxapine
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    8-hydroxy Amoxapine

    CAS:
    <p>8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2</p>
    Formula:C17H16ClN3O2
    Color and Shape:Solid
    Molecular weight:329.78

    Ref: TM-T37161

  • DCCCyb
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    DCCCyb

    CAS:
    <p>DCCCyb: oral GlyT1 inhibitor with high in vivo occupancy in rhesus monkeys, confirmed by PET tracer displacement.</p>
    Formula:C22H29Cl2NO3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:458.44

    Ref: TM-T25292

  • Org 24598 lithium salt
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    Org 24598 lithium salt

    CAS:
    Org 24598 lithium salt is a GlyT-1 inhibitor of glycine transporter 1.
    Formula:C19H19F3LiNO3
    Color and Shape:Solid
    Molecular weight:373.3

    Ref: TM-T37700

  • CymitQuimica logo
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    (Rac)-Oleoylcarnitine

    CAS:
    (Rac)-Oleoylcarnitine, an endogenous acylcarnitine, acts as a potential non-competitive inhibitor of glycine transporter 2 (GLYT2) and can be used as a pain suppressant.
    Formula:C25H47NO4
    Molecular weight:425.65

    Ref: TM-TN8218

  • SSR504734 HCl
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    SSR504734 HCl

    CAS:
    <p>SSR504734 inhibits GlyT1 in humans, rats, mice (IC50=18, 15, 38 nM); treats schizophrenia, anxiety, depression orally.</p>
    Formula:C20H21Cl2F3N2O
    Purity:98.05% - 99.93%
    Color and Shape:Solid
    Molecular weight:433.30

    Ref: TM-T90597

  • Bitopertin
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    Bitopertin

    CAS:
    Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM
    Formula:C21H20F7N3O4S
    Purity:98.57% - 98.71%
    Color and Shape:Solid
    Molecular weight:543.46

    Ref: TM-T6788

  • SSR504734
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    SSR504734

    CAS:
    SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.
    Formula:C20H20ClF3N2O
    Color and Shape:Solid
    Molecular weight:396.83

    Ref: TM-T28858

  • Org 25543 hydrochloride
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    Org 25543 hydrochloride

    CAS:
    Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2).
    Formula:C24H33ClN2O4
    Purity:99.26%
    Color and Shape:Solid
    Molecular weight:448.983

    Ref: TM-T22126

  • Opiranserin hydrochloride
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    Opiranserin hydrochloride

    CAS:
    Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM
    Formula:C21H35ClN2O5
    Purity:99.33%
    Color and Shape:Solid
    Molecular weight:430.97

    Ref: TM-T9833

  • Sarcosine
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    Sarcosine

    CAS:
    Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
    Formula:C3H7NO2
    Purity:99.90%
    Color and Shape:Deliquescent Water Soluble Physical Description Deliquescent Crystals Or Powder Has A Sweetish Taste (Ntp 1992)
    Molecular weight:89.09

    Ref: TM-T6975

  • MPDC
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    MPDC

    CAS:
    MPDC acts as a competitive inhibitor against the Na+-dependent high-affinity glutamate transporter within forebrain synaptosomes.
    Formula:C7H9NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:171.15

    Ref: TM-T12099

  • Org-25935
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    Org-25935

    CAS:
    Org-25935, a GlyT-1 inhibitor, is used potentially for the treatment of schizophrenia and alcohol dependence.
    Formula:C21H26ClNO3
    Color and Shape:Solid
    Molecular weight:375.89

    Ref: TM-T28260

  • NFPS
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    NFPS

    CAS:
    NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.
    Formula:C24H24FNO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:393.45

    Ref: TM-T16292

  • PF-03463275 2HCl
    Targetmol
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    PF-03463275 2HCl

    CAS:
    <p>PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, a GlyT1 glycine transporter.</p>
    Formula:C19H24Cl3FN4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:449.78

    Ref: TM-T28364

  • Bitopertin (R enantiomer)
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    Bitopertin (R enantiomer)

    CAS:
    Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin.
    Formula:C21H20F7N3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:543.46

    Ref: TM-T10552

  • GSK931145
    Targetmol
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    GSK931145

    CAS:
    GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain.
    Formula:C23H30N2O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:350.5

    Ref: TM-T27494

  • Org 24598
    Targetmol
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    Org 24598

    CAS:
    Potent GlyT1b inhibitor, IC50 = 6.9 nM; little effect on GlyT-2, adrenoceptors, dopamine, 5HT receptors, GABA transporters.
    Formula:C19H20F3NO3
    Color and Shape:Solid
    Molecular weight:367.36

    Ref: TM-T37699

  • Tilapertin
    Targetmol
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    Tilapertin

    CAS:
    Tilapertin is an oral glycine transporter type-1 inhibitor.
    Formula:C20H21F3N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.39

    Ref: TM-T17096

  • Opiranserin
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    Opiranserin

    CAS:
    Opiranserin is a development as an injectable agent for the treatment of postoperative pain.
    Formula:C21H34N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:394.51

    Ref: TM-T16399