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Beta Amyloid

Beta Amyloid

Beta Amyloid inhibitors are compounds that target and prevent the formation or aggregation of beta-amyloid peptides, which are implicated in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is a hallmark of the disease, leading to neuronal dysfunction and cognitive decline. Inhibitors of beta-amyloid aggregation are being explored as potential therapeutic agents to slow or prevent the progression of Alzheimer's disease. At CymitQuimica, we provide a range of beta-amyloid inhibitors to support your research in neurodegeneration, protein aggregation, and Alzheimer's therapy.

Found 204 products of "Beta Amyloid"

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  • γ-Secretase-IN-1
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    γ-Secretase-IN-1

    CAS:
    <p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>
    Formula:C27H24F2N4O3
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:490.5

    Ref: TM-T3521

  • MDR-1339
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    MDR-1339

    CAS:
    <p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>
    Formula:C20H22O4
    Purity:98.57%
    Color and Shape:Solid
    Molecular weight:326.39

    Ref: TM-TQ0026

  • BF-168
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    BF-168

    CAS:
    <p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>
    Formula:C18H17FN2O2
    Color and Shape:Solid
    Molecular weight:312.34

    Ref: TM-T10529

  • Amyloid-β-IN-3
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    Amyloid-β-IN-3

    CAS:
    <p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>
    Formula:C22H21F2N3O2
    Color and Shape:Solid
    Molecular weight:397.42

    Ref: TM-T207233

  • (9R)-RO7185876
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    (9R)-RO7185876

    CAS:
    <p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>
    Formula:C25H28F3N7
    Color and Shape:Solid
    Molecular weight:483.532

    Ref: TM-T204358

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    cSPM

    <p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>
    Formula:C27H57N7
    Color and Shape:Solid
    Molecular weight:479.79

    Ref: TM-T63163

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    Aβ-IN-2

    <p>Aβ-IN-2 is a peptide inhibitor of Aβ1-42.</p>
    Formula:C37H51NO
    Color and Shape:Solid
    Molecular weight:525.81

    Ref: TM-T63689

  • Amilo-5MER
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    Amilo-5MER

    CAS:
    <p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>
    Formula:C23H40N6O9S
    Color and Shape:Solid
    Molecular weight:576.664

    Ref: TM-TP3229

  • γ-secretase modulator 6
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    γ-secretase modulator 6

    CAS:
    <p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>
    Formula:C25H26N6O2
    Color and Shape:Solid
    Molecular weight:442.513

    Ref: TM-T206107

  • Antioxidant agent-8
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    Antioxidant agent-8

    <p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation &amp; promotes disaggregation; it's neuroprotective &amp; BBB permeable.</p>
    Formula:C13H12O5
    Color and Shape:Solid
    Molecular weight:248.23

    Ref: TM-T72506

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    MAO-B-IN-10

    <p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>
    Formula:C23H26N2O4
    Color and Shape:Solid
    Molecular weight:394.46

    Ref: TM-T61830

  • Aβ aggregation-IN-1
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    Aβ aggregation-IN-1

    CAS:
    <p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>
    Formula:C9H8BF3O2
    Color and Shape:Solid
    Molecular weight:215.965

    Ref: TM-T204182

  • Amyloid-β-IN-2
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    Amyloid-β-IN-2

    CAS:
    <p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>
    Formula:C22H21F2N3O2
    Color and Shape:Solid
    Molecular weight:397.42

    Ref: TM-T207418

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    Anti-Aβ agent 1A

    <p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>
    Formula:C35H49NO4
    Color and Shape:Solid
    Molecular weight:547.77

    Ref: TM-T63873

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    QP5020

    CAS:
    <p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>
    Formula:C20H19FN6
    Molecular weight:362.40

    Ref: TM-T208804

  • Buntanetap L-Tartrate
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    Buntanetap L-Tartrate

    CAS:
    <p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>
    Formula:C24H29N3O8
    Color and Shape:Solid
    Molecular weight:487.50

    Ref: TM-T85929

  • Aβ42 agonist-1
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    Aβ42 agonist-1

    CAS:
    <p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>
    Formula:C15H11NO2
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:237.25

    Ref: TM-T85792

  • 2002-G12
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    2002-G12

    CAS:
    <p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>
    Formula:C20H16N6
    Color and Shape:Solid
    Molecular weight:340.381

    Ref: TM-T204830

  • Glutaminyl Cyclase Inhibitor 3
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    Glutaminyl Cyclase Inhibitor 3

    CAS:
    <p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>
    Formula:C24H32N6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:468.61

    Ref: TM-T11422

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    γ-secretase modulator 5

    <p>Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.</p>
    Color and Shape:Solid

    Ref: TM-T64258