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Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.

Found 562 products of "Cyclooxygenase (COX) Inhibitors"

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  • FPL 62064
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    FPL 62064

    CAS:
    <p>FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin</p>
    Formula:C16H15N3O
    Purity:98.79%
    Color and Shape:Solid
    Molecular weight:265.31

    Ref: TM-T8356

  • CAFESTOL
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    CAFESTOL

    CAS:
    <p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>
    Formula:C20H28O3
    Purity:97.06% - 99.08%
    Color and Shape:Solid
    Molecular weight:316.43

    Ref: TM-T5727

  • NS-398
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    NS-398

    CAS:
    <p>NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a COX-2 inhibitor wih anti-inflammatory activity.</p>
    Formula:C13H18N2O5S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:314.36

    Ref: TM-T3214

  • TFAP
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    TFAP

    CAS:
    <p>TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor</p>
    Formula:C13H10F3N3O
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:281.23

    Ref: TM-T4643

  • Revaprazan hydrochloride
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    Revaprazan hydrochloride

    CAS:
    <p>Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.</p>
    Formula:C22H24ClFN4
    Purity:99.62% - 99.91%
    Color and Shape:Solid
    Molecular weight:398.9

    Ref: TM-T2405

  • Byakangelicol
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    Byakangelicol

    CAS:
    <p>Byakangelicol may reduce P-gp at BBB and has anti-inflammatory effects by hindering COX-2 and PGE2 in A549 cells.</p>
    Formula:C17H16O6
    Purity:98.78% - 99.55%
    Color and Shape:Solid
    Molecular weight:316.31

    Ref: TM-T6S0077

  • Pectolinarigenin
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    Pectolinarigenin

    CAS:
    <p>Pectolinarigenin has hepatoprotective and anti-inflammatory properties, acting through SOD and inhibiting eicosanoids.</p>
    Formula:C17H14O6
    Purity:98.67% - 99.88%
    Color and Shape:Solid
    Molecular weight:314.29

    Ref: TM-T6S0413

  • Compound Lup-20(29)-en-3-yl acetate
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    Compound Lup-20(29)-en-3-yl acetate

    <p>Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.</p>
    Formula:C32H52O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:468.75

    Ref: TM-TC0036

  • N-tert-butyl-α-Phenylnitrone
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    N-tert-butyl-α-Phenylnitrone

    CAS:
    <p>N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.</p>
    Formula:C11H15NO
    Purity:99.46% - 99.84%
    Color and Shape:Solid
    Molecular weight:177.24

    Ref: TM-T23046

  • CAY10404
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    CAY10404

    CAS:
    <p>CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.</p>
    Formula:C17H12F3NO3S
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:367.34

    Ref: TM-T8656

  • Tinoridine hydrochloride
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    Tinoridine hydrochloride

    CAS:
    <p>Tinoridine HCl is an NSAID that inhibits lipid peroxides and renin release, unlike indomethacin and corticosteroids.</p>
    Formula:C17H21ClN2O2S
    Purity:97.49%
    Color and Shape:Solid
    Molecular weight:352.88

    Ref: TM-T4313

  • Isofraxidin
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    Isofraxidin

    CAS:
    <p>Isofraxidin combats leukemia, ALI, and inflammation by modulating ROS, COX-2, PGE2, TNF-α, and p38/ERK1/2 pathways.</p>
    Formula:C11H10O5
    Purity:99.51% - ≥95%
    Color and Shape:Solid
    Molecular weight:222.19

    Ref: TM-T5S0045

  • Tolmetin
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    Tolmetin

    CAS:
    <p>Tolmetin (Tolectin) NSAID; acts as a cyclooxygenase inhibitor; classified as an anti-inflammatory.</p>
    Formula:C15H15NO3
    Purity:99.74% - >99.99%
    Color and Shape:Off-White Crystalline Power
    Molecular weight:257.28

    Ref: TM-T2550

  • [10]-Shogaol
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    [10]-Shogaol

    CAS:
    <p>[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects.</p>
    Formula:C21H32O3
    Purity:97.64% - 98.65%
    Color and Shape:Solid
    Molecular weight:332.48

    Ref: TM-T5431

  • α-Spinasterol
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    α-Spinasterol

    CAS:
    <p>α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects.</p>
    Formula:C29H48O
    Purity:97.03% - 99.58%
    Color and Shape:Solid
    Molecular weight:412.69

    Ref: TM-TN1377

  • Mofezolac
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    Mofezolac

    CAS:
    <p>Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index &gt; 6000</p>
    Formula:C19H17NO5
    Purity:99.29%
    Color and Shape:Solid
    Molecular weight:339.34

    Ref: TM-T5460

  • Firocoxib
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    Firocoxib

    CAS:
    <p>Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.</p>
    Formula:C17H20O5S
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:336.4

    Ref: TM-T7596

  • Parecoxib
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    Parecoxib

    CAS:
    <p>Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.</p>
    Formula:C19H18N2O4S
    Purity:99.71% - 99.78%
    Color and Shape:Solid
    Molecular weight:370.42

    Ref: TM-T1780

  • Tazofelone
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    Tazofelone

    CAS:
    <p>Tazofelone (LY-213829) is a NSAID used for the treatment of inflammatory bowel disease.</p>
    Formula:C18H27NO2S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:321.48

    Ref: TM-T22437

  • (E)-Ethyl p-methoxycinnamate
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    (E)-Ethyl p-methoxycinnamate

    CAS:
    <p>1. (E)-Ethyl p-methoxycinnamate (EPMC) is an anticarcinogenic agent. 2. (E)-Ethyl p-methoxycinnamate (EPMC) is a glutathion S tranferase inhibitor.</p>
    Formula:C12H14O3
    Purity:97.43%
    Color and Shape:Solid
    Molecular weight:206.24

    Ref: TM-T2S1625

  • RK33
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    RK33

    CAS:
    <p>"RK33 is a DDX3 inhibitor causing G1 arrest, apoptosis, and radiation sensitization in DDX3-overexpressing cells."</p>
    Formula:C23H20N6O3
    Purity:99.04% - 99.72%
    Color and Shape:Solid
    Molecular weight:428.44

    Ref: TM-T6970

  • Cis-5-Dodecenoic Acid
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    Cis-5-Dodecenoic Acid

    CAS:
    <p>Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position.</p>
    Formula:C12H22O2
    Purity:98% - 99.37%
    Color and Shape:Solid
    Molecular weight:198.3

    Ref: TM-T8240

  • Madecassic acid
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    Madecassic acid

    CAS:
    <p>Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.</p>
    Formula:C30H48O6
    Purity:98.80% - 99.69%
    Color and Shape:Solid
    Molecular weight:504.7

    Ref: TM-T2758

  • Gnetol
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    Gnetol

    CAS:
    <p>Gnetol inhibits butyrylcholinesterase (IC50: 1.3 μM), tyrosinase, melanin synthesis in B16 cells, and AA-induced platelet aggregation.</p>
    Formula:C14H12O4
    Purity:98.55% - ≥95%
    Color and Shape:Solid
    Molecular weight:244.24

    Ref: TM-T7052

  • Columbin
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    Columbin

    CAS:
    <p>Columbin: anti-inflammatory, prevents colon cancer, inhibits PLA2 in RBC dose-dependently.</p>
    Formula:C20H22O6
    Purity:99.34% - 99.74%
    Color and Shape:Solid
    Molecular weight:358.39

    Ref: TM-T4S0590

  • S-(+)-Marmesin
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    S-(+)-Marmesin

    CAS:
    <p>S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.</p>
    Formula:C14H14O4
    Purity:98.00% - ≥98%
    Color and Shape:Solid
    Molecular weight:246.26

    Ref: TM-T5759

  • Losartan Carboxaldehyde
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    Losartan Carboxaldehyde

    CAS:
    <p>Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.</p>
    Formula:C22H21ClN6O
    Purity:99.1%
    Color and Shape:Solid
    Molecular weight:420.89

    Ref: TM-T7838

  • Esculentoside A
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    Esculentoside A

    CAS:
    <p>Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.</p>
    Formula:C42H66O16
    Purity:98% - 99.85%
    Color and Shape:Solid
    Molecular weight:826.96

    Ref: TM-T3877

  • Isoorientin
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    Isoorientin

    CAS:
    <p>Isoorientin (Homoorientin) has antioxidant activity.</p>
    Formula:C21H20O11
    Purity:98.84% - 99.93%
    Color and Shape:Solid
    Molecular weight:448.38

    Ref: TM-T6S0722

  • Psoralidin
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    Psoralidin

    CAS:
    <p>Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally.</p>
    Formula:C20H16O5
    Purity:98% - 99.61%
    Color and Shape:Solid
    Molecular weight:336.34

    Ref: TM-T3399

  • 2,5-Di-tert-butylhydroquinone
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    2,5-Di-tert-butylhydroquinone

    CAS:
    <p>2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.</p>
    Formula:C14H22O2
    Purity:97.11%
    Color and Shape:Pelletslargecrystals
    Molecular weight:222.32

    Ref: TM-T7540

  • (+)-Catechin Hydrate
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    (+)-Catechin Hydrate

    CAS:
    <p>(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological</p>
    Formula:C15H16O7
    Purity:99.03% - 99.96%
    Color and Shape:Solid
    Molecular weight:308.28

    Ref: TM-T2778

  • Chlorotrianisene
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    Chlorotrianisene

    CAS:
    <p>Chlorotrianisene, a synthetic SERM, is orally active, lipophilic, and has estrogenic and antiestrogenic effects.</p>
    Formula:C23H21ClO3
    Purity:98.88% - 99.03%
    Color and Shape:Crystals From Methanol Physical Description Small White Crystals Or White Powder Softens At 226°F Odorless (Ntp 1992)
    Molecular weight:380.86

    Ref: TM-T2569

  • Avicularin
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    Avicularin

    CAS:
    <p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>
    Formula:C20H18O11
    Purity:97.02% - 99.94%
    Color and Shape:White Powder
    Molecular weight:434.35

    Ref: TM-T6S0117

  • [8]-Shogaol
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    [8]-Shogaol

    CAS:
    <p>[8]-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.</p>
    Formula:C19H28O3
    Purity:97.01%
    Color and Shape:Solid
    Molecular weight:304.42

    Ref: TM-T5430

  • Diclofenac Potassium
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    Diclofenac Potassium

    CAS:
    <p>Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.</p>
    Formula:C14H10Cl2KNO2
    Purity:99.51%
    Color and Shape:White To Yellowish Crystalline Powder
    Molecular weight:334.24

    Ref: TM-T6470

  • Lumiracoxib
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    Lumiracoxib

    CAS:
    <p>Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.</p>
    Formula:C15H13ClFNO2
    Purity:96.64% - 99.77%
    Color and Shape:Pale Yellow Solid
    Molecular weight:293.72

    Ref: TM-T6574

  • (-)-Catechin gallate
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    (-)-Catechin gallate

    CAS:
    <p>(-)-Catechin gallate inhibits 6PGD, IDH, Beta-secretase, and fights chloroquine-sensitive/resistant Plasmodium falciparum.</p>
    Formula:C22H18O10
    Purity:97.74% - >99.99%
    Color and Shape:Solid
    Molecular weight:442.37

    Ref: TM-T3682

  • Adelmidrol
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    Adelmidrol

    CAS:
    <p>Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.</p>
    Formula:C13H26N2O4
    Purity:99.35% - 99.73%
    Color and Shape:Solid
    Molecular weight:274.36

    Ref: TM-T3954

  • 7,3',4'-Tri-O-methylluteolin
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    7,3',4'-Tri-O-methylluteolin

    CAS:
    <p>7,3',4'-Tri-O-methylluteolin is anti-inflammatory, antibacterial, antifungal, and has moderate antitrypanosomal effects (MIC 19.0 ug/ml).</p>
    Formula:C18H16O6
    Purity:98.66% - 99.79%
    Color and Shape:Solid
    Molecular weight:328.32

    Ref: TM-TN1291

  • sphondin
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    sphondin

    CAS:
    <p>Sphondin inhibits IL-1beta, reduces COX-2 and PGE(2) in A549 cells, and has anticonvulsant, anti-inflammatory, anti-proliferative properties.</p>
    Formula:C12H8O4
    Purity:99.9% - ≥95%
    Color and Shape:Solid
    Molecular weight:216.19

    Ref: TM-T5758

  • Ginsenoside Rb3
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    Ginsenoside Rb3

    CAS:
    <p>Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity.</p>
    Formula:C53H90O22
    Purity:98% - 99.98%
    Color and Shape:Solid
    Molecular weight:1079.27

    Ref: TM-T3918

  • SC-58125
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    SC-58125

    CAS:
    <p>SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor. SC-58125 exhibits antitumor activity, and also inhibits oedema at sites of inflammation.</p>
    Formula:C17H12F4N2O2S
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:384.35

    Ref: TM-T23333

  • Roburic acid
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    Roburic acid

    CAS:
    <p>Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.</p>
    Formula:C30H48O2
    Purity:98.765% - 99.88%
    Color and Shape:Solid
    Molecular weight:440.7

    Ref: TM-T3883

  • Tinoridine
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    Tinoridine

    CAS:
    <p>Tinoridine is a quinoline derivative analog that acts by inhibiting the production of cyclooxygenase-2 (COX-2).</p>
    Formula:C17H20N2O2S
    Purity:99.08%
    Color and Shape:Solid
    Molecular weight:316.42

    Ref: TM-T50001

  • FK 3311
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    FK 3311

    CAS:
    <p>FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (</p>
    Formula:C15H13F2NO4S
    Purity:97.98%
    Color and Shape:Solid
    Molecular weight:341.33

    Ref: TM-T7207

  • Propyphenazone
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    Propyphenazone

    CAS:
    <p>Propyphenazone: an anti-inflammatory, analgesic, antipyretic pyrazolone; prodrug; COX-2 inhibitor.</p>
    Formula:C14H18N2O
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:230.31

    Ref: TM-T5010

  • Teriflunomide impurity 3
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    Teriflunomide impurity 3

    CAS:
    <p>Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor(IC50 of 30 μM).</p>
    Formula:C14H11F3N2O
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:280.25

    Ref: TM-T9042

  • Otenaproxesul
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    Otenaproxesul

    CAS:
    <p>Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.</p>
    Formula:C21H19NO3S
    Purity:98.76% - 99.13%
    Color and Shape:Solid
    Molecular weight:365.45

    Ref: TM-T1867

  • Fenoprofen Calcium
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    Fenoprofen Calcium

    CAS:
    <p>Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.</p>
    Formula:C30H26CaO6
    Purity:99.24% - 99.66%
    Color and Shape:Solid
    Molecular weight:522.6

    Ref: TM-T6497