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Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.

Found 562 products of "Cyclooxygenase (COX) Inhibitors"

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  • (-)-Epicatechin
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    (-)-Epicatechin

    CAS:
    <p>(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization</p>
    Formula:C15H14O6
    Purity:98.55% - 98.80%
    Color and Shape:Solid
    Molecular weight:290.27

    Ref: TM-T2856

  • Licofelone
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    Licofelone

    CAS:
    <p>Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.</p>
    Formula:C23H22ClNO2
    Purity:99.25%
    Color and Shape:Yellowish Solid
    Molecular weight:379.88

    Ref: TM-T6568

  • SC-236
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    SC-236

    CAS:
    <p>SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).</p>
    Formula:C16H11ClF3N3O2S
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:401.79

    Ref: TM-T8505

  • Chebulagic acid
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    Chebulagic acid

    CAS:
    <p>Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.</p>
    Formula:C41H30O27
    Purity:97.82% - 99.8%
    Color and Shape:Solid
    Molecular weight:954.66

    Ref: TM-TQ0180

  • (-)-Epicatechin gallate
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    (-)-Epicatechin gallate

    CAS:
    <p>(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.</p>
    Formula:C22H18O10
    Purity:99.16% - 99.93%
    Color and Shape:Solid
    Molecular weight:442.37

    Ref: TM-T2732

  • Flurbiprofen Axetil
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    Flurbiprofen Axetil

    CAS:
    <p>Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.</p>
    Formula:C19H19FO4
    Purity:97.58% - 98%
    Color and Shape:Solid
    Molecular weight:330.35

    Ref: TM-T3500

  • Phenidone
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    Phenidone

    CAS:
    <p>Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.</p>
    Formula:C9H10N2O
    Purity:97.24%
    Color and Shape:White Solid Solid Crystalline
    Molecular weight:162.19

    Ref: TM-T22398

  • Ataquimas
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    Ataquimas

    CAS:
    <p>Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.</p>
    Formula:C11H13N3O
    Purity:99.96%
    Color and Shape:Solid
    Molecular weight:203.24

    Ref: TM-T9840

  • Neochlorogenic acid
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    Neochlorogenic acid

    CAS:
    <p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>
    Formula:C16H18O9
    Purity:99.12% - 99.54%
    Color and Shape:White Powder
    Molecular weight:354.31

    Ref: TM-T6S1538

  • Ibuprofen Lysine
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    Ibuprofen Lysine

    CAS:
    <p>Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.</p>
    Formula:C19H32N2O4
    Purity:99.26%
    Color and Shape:Coa
    Molecular weight:352.47

    Ref: TM-T6540

  • 3-TERT-BUTYL-4-HYDROXYANISOLE
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    3-TERT-BUTYL-4-HYDROXYANISOLE

    CAS:
    <p>3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.</p>
    Formula:C11H16O2
    Purity:99.65%
    Color and Shape:White Solid Waxy
    Molecular weight:180.24

    Ref: TM-T5367

  • Diclofenac Epolamine
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    Diclofenac Epolamine

    CAS:
    <p>Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions.</p>
    Formula:C20H24Cl2N2O3
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:411.32

    Ref: TM-T22307

  • SC-560
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    SC-560

    CAS:
    <p>SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.</p>
    Formula:C17H12ClF3N2O
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:352.74

    Ref: TM-T4101

  • Prim-O-glucosylcimifugin
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    Prim-O-glucosylcimifugin

    CAS:
    <p>Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC stimulated by TNF-alpha, increase the proportion of G0/G1 phase.</p>
    Formula:C22H28O11
    Purity:98.57% - 99.92%
    Color and Shape:Solid
    Molecular weight:468.45

    Ref: TM-T3805

  • RHC 80267
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    RHC 80267

    CAS:
    <p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>
    Formula:C20H34N4O4
    Purity:99.54%
    Color and Shape:White Solid
    Molecular weight:394.51

    Ref: TM-T8236

  • ETHYL CAFFEATE
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    ETHYL CAFFEATE

    CAS:
    <p>Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.</p>
    Formula:C11H12O4
    Purity:97.79%
    Color and Shape:Solid
    Molecular weight:208.21

    Ref: TM-T5681

  • Ufenamate
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    Ufenamate

    CAS:
    <p>Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases</p>
    Formula:C18H18F3NO2
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:337.34

    Ref: TM-T4966

  • Veratric acid
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    Veratric acid

    CAS:
    <p>Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-</p>
    Formula:C9H10O4
    Purity:99.44%
    Color and Shape:Solid
    Molecular weight:182.17

    Ref: TM-T3744

  • Indomethacin farnesil
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    Indomethacin farnesil

    CAS:
    <p>Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.</p>
    Formula:C34H40ClNO4
    Purity:97.29%
    Color and Shape:Solid
    Molecular weight:562.14

    Ref: TM-T7882

  • N-trans-Feruloyltyramine
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    N-trans-Feruloyltyramine

    CAS:
    <p>NTF is hepatoprotective, antioxidant, inhibits COX, prevents platelet aggregation, and reduces melanin by downregulating tyrosinase.</p>
    Formula:C18H19NO4
    Purity:99.56% - >99.99%
    Color and Shape:Solid
    Molecular weight:313.35

    Ref: TM-T3S0645

  • Phenethyl ferulate
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    Phenethyl ferulate

    CAS:
    <p>Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).</p>
    Formula:C18H18O4
    Purity:99.88% - 99.91%
    Color and Shape:Solid
    Molecular weight:298.33

    Ref: TM-TN2330

  • (S)-Flurbiprofen
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    (S)-Flurbiprofen

    CAS:
    <p>Esflurbiprofen is an inhibitor of COX-1 and COX-2.</p>
    Formula:C15H13FO2
    Purity:99.99%
    Color and Shape:White To Yellowish Crystalline Powder
    Molecular weight:244.26

    Ref: TM-T5843L

  • Dehydrodiisoeugenol
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    Dehydrodiisoeugenol

    CAS:
    <p>Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.</p>
    Formula:C20H22O4
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:326.39

    Ref: TM-T6S1543

  • Ketorolac
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    Ketorolac

    CAS:
    <p>Ketorolac (Acuvail) is an NSAID that blocks prostaglandin synthesis, related to heterocyclic acetic acids.</p>
    Formula:C15H13NO3
    Purity:99.68%
    Color and Shape:White Crystalline Or White Powder
    Molecular weight:255.27

    Ref: TM-T21412

  • Xanthohumol
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    Xanthohumol

    CAS:
    <p>Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-</p>
    Formula:C21H22O5
    Purity:98.19% - 99.67%
    Color and Shape:Orange Powder
    Molecular weight:354.4

    Ref: TM-T3342

  • Loxoprofen sodium (dihydrate)
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    Loxoprofen sodium (dihydrate)

    CAS:
    <p>Loxoprofen sodium dihydrate: Non-steroidal anti-inflammatory with analgesic, antipyretic, antitumor effects; COX-1/COX-2 inhibitor. IC50: 6.5/13.5 μM.</p>
    Formula:C15H21NaO5
    Color and Shape:Solid
    Molecular weight:304.318

    Ref: TM-T60704

  • Tenidap
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    Tenidap

    CAS:
    <p>Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.</p>
    Formula:C14H9ClN2O3S
    Purity:98.56% - 99.42%
    Color and Shape:Solid
    Molecular weight:320.75

    Ref: TM-T17036

  • NF-κB/MAPK-IN-1
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    NF-κB/MAPK-IN-1

    CAS:
    <p>NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).</p>
    Formula:C27H27NO7
    Purity:97.03%
    Color and Shape:Solid
    Molecular weight:477.51

    Ref: TM-T63119

  • Bromfenac sodium hydrate
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    Bromfenac sodium hydrate

    CAS:
    <p>Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.</p>
    Formula:C15H12BrNO3H2O·Na
    Purity:91.85% - 99.65%
    Color and Shape:Solid
    Molecular weight:383.17

    Ref: TM-T2403

  • Oxyphenbutazone
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    Oxyphenbutazone

    CAS:
    <p>Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.</p>
    Formula:C19H20N2O3
    Purity:99.41% - 99.88%
    Color and Shape:White To Yellowish White Crystalline Powder Solid
    Molecular weight:324.37

    Ref: TM-T16419

  • Meloxicam
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    Meloxicam

    CAS:
    <p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>
    Formula:C14H13N3O4S2
    Purity:97.09% - 99.60%
    Color and Shape:Light Yellow Solid
    Molecular weight:351.40

    Ref: TM-T0826

  • Fenoprofen
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    Fenoprofen

    CAS:
    <p>Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, increasing ERK1/2 activation.</p>
    Formula:C15H14O3
    Purity:98.4%
    Color and Shape:Solid
    Molecular weight:242.27

    Ref: TM-T0184L

  • (S)-(+)-Ibuprofen
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    (S)-(+)-Ibuprofen

    CAS:
    <p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>
    Formula:C13H18O2
    Purity:99.51% - 99.86%
    Color and Shape:Colourless Crystalline Solid
    Molecular weight:206.28

    Ref: TM-T0448

  • Paradol
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    Paradol

    CAS:
    <p>Paradol, a spicy compound in ginger, offers anti-cancer, anti-inflammatory, antioxidant, and neuroprotective benefits.</p>
    Formula:C17H26O3
    Purity:98.4% - 98.98%
    Color and Shape:Solid
    Molecular weight:278.39

    Ref: TM-T7113

  • CymitQuimica logo
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    Fontolizumab

    CAS:
    <p>Fontolizumab (HuZAF) is a humanised IgG1 monoclonal anti-IFN-gamma (IFN-γ) antibody for the study of Crohn's disease.</p>
    Purity:95%
    Color and Shape:Liquid
    Molecular weight:150 (kDa)

    Ref: TM-T76808

  • Aspirin DL-lysine
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    Aspirin DL-lysine

    CAS:
    <p>Aspirin DL-lysine: a water-soluble, injectable NSAID that may also hinder cancer growth.</p>
    Formula:C15H22N2O6
    Color and Shape:Crystalline Solid
    Molecular weight:326.35

    Ref: TM-T20458

  • CymitQuimica logo
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    Cadonilimab

    CAS:
    <p>Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.</p>
    Purity:95% - 95%
    Color and Shape:Liquid

    Ref: TM-T76716

  • Imidazole Salicylate
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    Imidazole Salicylate

    CAS:
    <p>Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.</p>
    Formula:C10H10N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:206.2

    Ref: TM-T27597

  • Indometacin Farnesil
    TCI
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    Indometacin Farnesil

    CAS:
    Formula:C34H40ClNO4
    Purity:>98.0%(HPLC)
    Color and Shape:Light yellow to Yellow to Orange clear liquid
    Molecular weight:562.15

    Ref: 3B-I0943

    100mg
    414.00€
  • Ketorolac-d5
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    Ketorolac-d5

    CAS:
    <p>Ketorolac-d5 is a deuterated compound of ketorolac for isotope tracing. Ketorolac is a non-steroidal anti-inflammatory agent and inhibitor of COX-1 and COX-2.</p>
    Formula:C15H8D5NO3
    Purity:98.99%
    Color and Shape:Solid
    Molecular weight:260.3

    Ref: TM-T11754

  • Nepafenac-d5
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    Nepafenac-d5

    CAS:
    <p>Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .</p>
    Formula:C15H14N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:259.31

    Ref: TM-T12208

  • AHR-10037
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    AHR-10037

    CAS:
    <p>AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.</p>
    Formula:C15H13ClN2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:288.73

    Ref: TM-T23676

  • Amfenac
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    Amfenac

    CAS:
    <p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>
    Formula:C15H13NO3
    Color and Shape:Solid
    Molecular weight:255.27

    Ref: TM-T1720L

  • Pelubiprofen
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    Pelubiprofen

    CAS:
    <p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>
    Formula:C16H18O3
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:258.31

    Ref: TM-T16464

  • COX-2-IN-2
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    COX-2-IN-2

    CAS:
    <p>COX-2-IN-2 selectively inhibits COX2 (IC50: 0.24 μM); COX-2-IN-1 offers anti-inflammatory and pain relief.</p>
    Formula:C17H12FN3O2S
    Purity:97.62%
    Color and Shape:Solid
    Molecular weight:341.36

    Ref: TM-T10032

  • COX-2-IN-26
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    COX-2-IN-26

    CAS:
    <p>COX-2-IN-26: Oral, selective COX-2 inhibitor, low IC50s; anti-inflammatory with GI safety.</p>
    Formula:C23H21N7OS3
    Color and Shape:Solid
    Molecular weight:507.65

    Ref: TM-T63480

  • Loxoprofenol-SRS tromethamine
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    Loxoprofenol-SRS tromethamine

    CAS:
    <p>Loxoprofenol-SRS tromethamine (HR1405-01), a metabolite of Loxoprofen, is a safe IV NSAID with strong anti-inflammatory and pain relief properties.</p>
    Formula:C19H31NO6
    Color and Shape:Solid
    Molecular weight:369.45

    Ref: TM-T72146

  • COX-2-IN-24
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    COX-2-IN-24

    CAS:
    <p>COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.</p>
    Formula:C24H24BrN5O3S2
    Color and Shape:Solid
    Molecular weight:574.51

    Ref: TM-T64063

  • COX-2-IN-18
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    COX-2-IN-18

    CAS:
    <p>COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.</p>
    Formula:C18H19N3O3S2
    Color and Shape:Solid
    Molecular weight:389.49

    Ref: TM-T61760

  • COX-2-IN-14
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    COX-2-IN-14

    CAS:
    <p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>
    Formula:C18H18N4O6
    Color and Shape:Solid
    Molecular weight:386.364

    Ref: TM-T61711