Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 602 products of "Cyclooxygenase (COX) Inhibitors"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Guaiacol
CAS:Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.Formula:C7H8O2Purity:99.95%Color and Shape:Colourless To Pale Yellow Solid CrystallineMolecular weight:124.145-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
CAS:Formula:C14H12O3Purity:98%Color and Shape:SolidMolecular weight:228.2433Metamizole sodium hydrate
CAS:Metamizole sodium hydrate (Analgin) is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX).Formula:C13H18N3NaO5SPurity:99.69% - 99.89%Color and Shape:White Or Light Yellow Crystalline Powder Odorless Tiny BitterMolecular weight:351.36Nepafenac
CAS:Nepafenac (AHR 9434) is an NSAID that acts as a cyclooxygenase inhibitor.Formula:C15H14N2O2Purity:98.94% - 99.43%Color and Shape:SolidMolecular weight:254.283-(diphenyl-1,3-oxazol-2-yl)propanoic acid
CAS:Formula:C18H15NO3Purity:98%Color and Shape:SolidMolecular weight:293.31665-Amino-2-hydroxybenzoic acid
CAS:Formula:C7H7NO3Purity:97%Color and Shape:SolidMolecular weight:153.1354Ketoprofen
CAS:Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects.Formula:C16H14O3Purity:99.67% - 99.97%Color and Shape:SolidMolecular weight:254.2815-LOX-IN-2
15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.Color and Shape:Odour Solid4-ACETAMIDOANTIPYRINE
CAS:4-ACETAMIDOANTIPYRINE, with CAS No. 83-15-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-ACETAMIDOANTIPYRINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C13H15N3O2Color and Shape:SolidMolecular weight:245.28Sampeginterferon β-1a
CAS:Sampeginterferon beta-1a (BCD-054), a pegylated IFNβ-1a, is evaluated for its potential in research addressing remitting multiple sclerosis [1] [2].Color and Shape:LiquidTimegadine hydrochloride
CAS:Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine. It is an orally active inhibitor of COX and lipo-oxygenase, effectively suppressing COX in rabbit platelets and rat brain with IC50 values of 5 nM and 20 μM, respectively, and inhibiting lipo-oxygenase in horse and rabbit platelets with an IC50 of 100 μM. Timegadine hydrochloride also exhibits anti-arthritis activity.Formula:C20H24ClN5SColor and Shape:SolidMolecular weight:401.961a,1b-dihomo Prostaglandin E2
CAS:1a,1b-dihomo PGE2: rare fatty acid, found in stimulated sheep gland microsomes and RAW 264.7 macrophages; made by AA elongation and COX metabolism.Formula:C22H36O5Color and Shape:SolidMolecular weight:380.52COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Color and Shape:Odour SolidSARS-CoV-2 Mpro-IN-41
SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.Formula:C27H23ClN4O3SColor and Shape:SolidMolecular weight:518.11794NO-Indomethacin
CAS:NO-indomethacin is an indomethacin-NO hybrid, an NSAID with enhanced GI protection, less toxicity, and cancer-preventive traits; IC50 82 μM in PaCa-2.Formula:C28H30ClN3O9SColor and Shape:SolidMolecular weight:620.07Celecoxib Carboxylic Acid
CAS:Celecoxib carboxylic acid, an inactive byproduct of celecoxib, is mainly produced by CYP2C9, a cytochrome P450 enzyme.Formula:C17H12F3N3O4SColor and Shape:SolidMolecular weight:411.36Prostaglandin E3
CAS:Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, and shows anti-proliferative effects.Formula:C20H30O5Purity:98%Color and Shape:SolidMolecular weight:350.45Pemedolac
CAS:Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.Formula:C22H23NO3Purity:99.7%Color and Shape:SolidMolecular weight:349.42NF157
CAS:NF157, a selective P2Y11 antagonist with pKi 7.35, lowers MMP-3/MMP-13, aiding OA treatment; IC50s: P2Y11 463 nM, P2Y1 1811 μM, P2Y2 170 μM.Formula:C49H28F2N6Na6O23S6Purity:98%Color and Shape:SolidMolecular weight:1437.1
![5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA0035KE.webp&w=3840&q=75)
