Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 602 products of "Cyclooxygenase (COX) Inhibitors"
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Pemedolac
CAS:Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.Formula:C22H23NO3Purity:99.7%Color and Shape:SolidMolecular weight:349.42COX-1/2-IN-5
COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and
Formula:C21H22N2O5SPurity:98%Color and Shape:SolidMolecular weight:414.47COX-1/2-IN-4
COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2.Formula:C22H24N2O2SPurity:98%Color and Shape:SolidMolecular weight:380.5Ketoprofen lysine salt
CAS:Ketoprofen lysine salt is a lysine salt of ketoprofen, a Non-Steroidal Anti-Inflammatory DrugFormula:C22H28N2O5Color and Shape:SolidMolecular weight:400.48COX-2-IN-31
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM).Formula:C17H16N6O4SPurity:98%Color and Shape:SolidMolecular weight:400.41Chloranthalactone B
CAS:Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Formula:C15H16O3Color and Shape:SolidMolecular weight:244.291-Hydroxy-ibuprofen
CAS:1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.Formula:C13H18O3Color and Shape:SolidMolecular weight:222.2802COX-2/15-LOX-IN-3
COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM,Formula:C25H24FN3O3SPurity:98%Color and Shape:SolidMolecular weight:465.54MCI
MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammationFormula:C45H52ClN7O13Purity:98%Color and Shape:SolidMolecular weight:934.39Sampeginterferon β-1a
CAS:Sampeginterferon beta-1a (BCD-054), a pegylated IFNβ-1a, is evaluated for its potential in research addressing remitting multiple sclerosis [1] [2].Color and Shape:LiquidCOX-2-IN-35
COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].Formula:C22H19NO2S2Purity:98%Color and Shape:SolidMolecular weight:393.52Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.Formula:C38H56N2O4Purity:98%Color and Shape:SolidMolecular weight:604.86Antiviral agent 61
Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.Formula:C22H23N5O4SColor and Shape:SolidMolecular weight:453.51M-5011
CAS:M-5011: NSAID and immunomodulator for pain and inflammation; ED50 0.63mg/kg; reduces bone loss in arthritis; low ulcer risk.Formula:C14H14O2SPurity:98%Color and Shape:SolidMolecular weight:246.32Fentiazac
CAS:Fentiazac (BR-700) is an oral NSAID for pain, inflammation, fever, studied for arthritis and tendonitis.Formula:C17H12ClNO2SPurity:99.39%Color and Shape:SolidMolecular weight:329.8Anti-inflammatory agent 53
Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrestFormula:C24H22N2O4SPurity:98%Color and Shape:SolidMolecular weight:434.515-LOX/sEH-IN-1
Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.Color and Shape:Odour SolidCOX-2-IN-46
COX-2-IN-46 (compound 5m) serves as a potent anti-inflammatory and analgesic agent. It demonstrates a significant inhibitory action on COX-2, with an IC 50 value of 87.74 nM.Formula:C28H19F2N3SColor and Shape:SolidMolecular weight:467.53SARS-CoV-2 Mpro-IN-41
SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.Formula:C27H23ClN4O3SColor and Shape:SolidMolecular weight:518.117941a,1b-dihomo Prostaglandin E2
CAS:1a,1b-dihomo PGE2: rare fatty acid, found in stimulated sheep gland microsomes and RAW 264.7 macrophages; made by AA elongation and COX metabolism.Formula:C22H36O5Color and Shape:SolidMolecular weight:380.52
