Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 602 products of "Cyclooxygenase (COX) Inhibitors"
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COX-2/15-LOX-IN-2
COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.Formula:C27H26N6OS2Purity:98%Color and Shape:SolidMolecular weight:514.66COX-2-IN-49
COX-2-IN-49 (compound 6c) is a potent inhibitor of cyclooxygenase-2 (COX-2), displaying an IC50 value of 2.671 µM. This compound exhibits anti-proliferative properties and holds potential for use in cancer research.Color and Shape:Odour Solid1a,1b-dihomo Prostaglandin E2
CAS:1a,1b-dihomo PGE2: rare fatty acid, found in stimulated sheep gland microsomes and RAW 264.7 macrophages; made by AA elongation and COX metabolism.Formula:C22H36O5Color and Shape:SolidMolecular weight:380.52COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Color and Shape:Odour SolidSampeginterferon β-1a
CAS:Sampeginterferon beta-1a (BCD-054), a pegylated IFNβ-1a, is evaluated for its potential in research addressing remitting multiple sclerosis [1] [2].Color and Shape:Liquid4-Methylamino antipyrine hydrochloride
CAS:4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole.Formula:C12H16ClN3OPurity:98%Color and Shape:SolidMolecular weight:253.73Chloranthalactone B
CAS:Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Formula:C15H16O3Color and Shape:SolidMolecular weight:244.29NO-Indomethacin
CAS:NO-indomethacin is an indomethacin-NO hybrid, an NSAID with enhanced GI protection, less toxicity, and cancer-preventive traits; IC50 82 μM in PaCa-2.Formula:C28H30ClN3O9SColor and Shape:SolidMolecular weight:620.075-LOX/sEH-IN-1
Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.Color and Shape:Odour SolidAMK (hydrochloride)
CAS:AMK, a melatonin metabolite, scavenges oxygen, inhibits prostaglandin production, reduces lipid peroxidation, and affects Parkinson's in mouse studies.Formula:C12H17ClN2O3Color and Shape:SolidMolecular weight:272.73SARS-CoV-2 Mpro-IN-41
SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.Formula:C27H23ClN4O3SColor and Shape:SolidMolecular weight:518.11794Lobuprofen
CAS:Lobuprofen is a small molecule COX inhibitor that is used to treat neurological disorders.Formula:C25H33ClN2O2Purity:99.80%Color and Shape:SolidMolecular weight:428.99Celecoxib Carboxylic Acid
CAS:Celecoxib carboxylic acid, an inactive byproduct of celecoxib, is mainly produced by CYP2C9, a cytochrome P450 enzyme.Formula:C17H12F3N3O4SColor and Shape:SolidMolecular weight:411.36Prostaglandin E3
CAS:Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, and shows anti-proliferative effects.Formula:C20H30O5Purity:98%Color and Shape:SolidMolecular weight:350.45COX-1/2-IN-5
COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and
Formula:C21H22N2O5SPurity:98%Color and Shape:SolidMolecular weight:414.47O-Desmethyl-N-deschlorobenzoyl Indomethacin
CAS:O-Desmethyl-N-deschlorobenzoyl indomethacin, a metabolite of indomethacin, reduces HL-60 cell viability and aids in synthesizing PGD2 receptor antagonists.Formula:C11H11NO3Color and Shape:SolidMolecular weight:205.213Anti-inflammatory agent 50
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, andFormula:C40H55N3O6Purity:98%Color and Shape:SolidMolecular weight:673.88Hamaline
CAS:Hamaline (9-(4-chlorobenzyl)-6-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole) is a substrate-selective cyclooxygenase-2 (COX-2) inhibitor.Formula:C20H19ClN2OPurity:99.88%Color and Shape:SoildMolecular weight:338.83Ref: TM-T60053
1mg35.00€5mg69.00€1mL*10mM (DMSO)73.00€10mg87.00€25mg142.00€50mg202.00€100mg304.00€200mg434.00€COX-2-IN-52
COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.Formula:C16H13IN4O4S2Color and Shape:SolidMolecular weight:516.333Axinelline A
CAS:Axinelline A: COX inhibitor, IC50 of 2.22 μM (COX-2) & 8.89 μM (COX-1), anti-inflammatory.Formula:C12H15NO6Color and Shape:SolidMolecular weight:269.25
