Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 602 products of "Cyclooxygenase (COX) Inhibitors"
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1a,1b-dihomo Prostaglandin E2
CAS:1a,1b-dihomo PGE2: rare fatty acid, found in stimulated sheep gland microsomes and RAW 264.7 macrophages; made by AA elongation and COX metabolism.Formula:C22H36O5Color and Shape:SolidMolecular weight:380.52Ibuprofen impurity 1
CAS:Ibuprofen impurity 1: anti-inflammatory, inhibits COX-1/COX-2 with IC50s of 13 μM/370 μM.
Formula:C12H16O2Color and Shape:SolidMolecular weight:192.258COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Color and Shape:Odour SolidAmfenac sodium
CAS:Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.Formula:C15H12NNaO3Purity:98%Color and Shape:SolidMolecular weight:277.26COX-2/15-LOX-IN-4
COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX.Formula:C23H20FN3OSPurity:98%Color and Shape:SolidMolecular weight:405.49Lonazolac Calcium
CAS:Lonazolac Calcium, a nonsteroidal anti-inflammatory drug (NSAID), is used to treat inflammation and pain.Formula:C34H24CaCl2N4O4Purity:98%Color and Shape:SolidMolecular weight:663.56Sampeginterferon β-1a
CAS:Sampeginterferon beta-1a (BCD-054), a pegylated IFNβ-1a, is evaluated for its potential in research addressing remitting multiple sclerosis [1] [2].Color and Shape:LiquidC2 Ceramide (d14:1/2:0)
CAS:C2 Ceramide (d14:1/2:0), a bioactive sphingolipid, causes lipotoxic cardiomyopathy when fed to Drosophila at 100 μM.Formula:C16H31NO3Color and Shape:SolidMolecular weight:285.42Prostaglandin E3
CAS:Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, and shows anti-proliferative effects.Formula:C20H30O5Purity:98%Color and Shape:SolidMolecular weight:350.45Chloranthalactone B
CAS:Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Formula:C15H16O3Color and Shape:SolidMolecular weight:244.29COX-2/NLRP3-IN-1
CAS:COX-2/NLRP3-IN-1 (Compound 6k) is an inhibitor that targets COX-2 and NLRP3, exhibiting an IC50 value of 1.53 μM for COX-2. This compound exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway.Formula:C24H19Cl2N5OSColor and Shape:SolidMolecular weight:496.41AMK (hydrochloride)
CAS:AMK, a melatonin metabolite, scavenges oxygen, inhibits prostaglandin production, reduces lipid peroxidation, and affects Parkinson's in mouse studies.Formula:C12H17ClN2O3Color and Shape:SolidMolecular weight:272.73Celecoxib Carboxylic Acid
CAS:Celecoxib carboxylic acid, an inactive byproduct of celecoxib, is mainly produced by CYP2C9, a cytochrome P450 enzyme.Formula:C17H12F3N3O4SColor and Shape:SolidMolecular weight:411.36Ketoprofen L-thyroxine ester
Ketoprofen L-thyroxine ester, a prodrug of ketoprofen, acts as a reservoir to slowly release ketoprofen in the brain [1].Color and Shape:Odour SolidDiclofenac ethyl ester
CAS:Diclofenac ethyl ester can be used in related research in the field of life sciences. Its product number is T37481 and CAS number is 15307-77-4.Formula:C16H15Cl2NO2Color and Shape:SolidMolecular weight:324.2Anti-inflammatory agent 78
Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. It effectively inhibits PGE2, PGE1, COX-2, and COX-1. Additionally, Anti-inflammatory agent 78 suppresses the release of NO in LPS-stimulated RAW 264.7 cell lines.Formula:C19H14ClNO4Molecular weight:355.06114Withangulatin A
CAS:Withangulatin A, a COX-2 inhibitor from Physalis angulata, has anti-tumor and anti-inflammatory effects.Formula:C30H38O8Color and Shape:SolidMolecular weight:526.62NO-Indomethacin
CAS:NO-indomethacin is an indomethacin-NO hybrid, an NSAID with enhanced GI protection, less toxicity, and cancer-preventive traits; IC50 82 μM in PaCa-2.Formula:C28H30ClN3O9SColor and Shape:SolidMolecular weight:620.07Rebamipide-d4
CAS:Rebamipide D4 is deuterium labeled Rebamipide.Formula:C19H15ClN2O4Purity:98%Color and Shape:SolidMolecular weight:374.81Parecoxib sodium
CAS:Parecoxib: COX2 inhibitor, treats short-term postoperative pain, water-soluble, injectable, valdecoxib prodrug, less GI toxicity than ketorolac.Formula:C19H18N2NaO4SPurity:98%Color and Shape:SolidMolecular weight:393.41
