BACE
BACE inhibitors are compounds that target the Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), which is crucial for the production of beta-amyloid, a protein associated with the formation of amyloid plaques in Alzheimer's disease. By inhibiting BACE, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, potentially slowing the progression of Alzheimer's disease. BACE inhibitors are a major focus in the development of therapeutic strategies for neurodegenerative diseases. At CymitQuimica, we offer BACE inhibitors to support your research in Alzheimer's disease, amyloid biology, and neurodegeneration.
Found 36 products of "BACE"
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Elenbecestat
CAS:<p>Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.</p>Formula:C19H18F3N5O2SPurity:99.95%Color and Shape:SolidMolecular weight:437.44BACE1 Protein, Human, Recombinant (hFc)
<p>BACE1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>Color and Shape:Lyophilized PowderMolecular weight:75.2 kDa (predicted, pro-form); 72.6 kDa (predicted, mature-form); 85-100 kDa (reducing condition, due to glycosylation)Anti-BACE1 Antibody-FITC (8D358)
<p>Anti-BACE1 Antibody-FITC (8D358) is a FITC-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-FITC (8D358) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-BACE1 Antibody-PE (8D358)
<p>Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-BACE1 Antibody (2Z488)
<p>Anti-BACE1 Antibody (2Z488) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (2Z488) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-BACE1 Antibody (2J206)
<p>Anti-BACE1 Antibody (2J206) is an antibody targeting BACE1. Anti-BACE1 Antibody (2J206) can be used in ELISA, WB.</p>Color and Shape:Odour LiquidAnti-BACE1 Antibody (8A762)
<p>Anti-BACE1 Antibody (8A762) is a Rabbit antibody targeting BACE1. Anti-BACE1 Antibody (8A762) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-BACE1 Antibody (3R945)
<p>Anti-BACE1 Antibody (3R945) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (3R945) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-BACE1 Antibody (8D358)
<p>Anti-BACE1 Antibody (8D358) is a Rabbit antibody targeting BACE1. Anti-BACE1 Antibody (8D358) can be used in FCM,ICC/IF.</p>Color and Shape:Odour LiquidBACE1 Protein, Human, Recombinant
<p>BACE1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 49 kDa and the accession number is A0A024R3D7.</p>Color and Shape:Lyophilized PowderMolecular weight:49 kDa (predicted); 65 kDa (reducing condition, due to glycosylation)BACE1 Protein, Human, Recombinant (His)
<p>BACE1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Color and Shape:Lyophilized PowderMolecular weight:49.5 kDa (predicted); 55-70 kDa (reducing condition, due to glycosylation)Verubecestat
CAS:<p>Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.</p>Formula:C17H17F2N5O3SPurity:92.24% - 99.55%Color and Shape:SolidMolecular weight:409.41LY2811376
CAS:<p>LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).</p>Formula:C15H14F2N4SPurity:99% - 99.01%Color and Shape:SolidMolecular weight:320.36BACE-IN-1 acetate
<p>BACE-IN-1 acetate (350228-37-4), a BACE1 inhibitor with three disulfide bonds and N-linked glycosylation, is used in assays.</p>Formula:C75H122N16O29Purity:96.98%Color and Shape:SolidMolecular weight:1711.86Sophoflavescenol
CAS:<p>Sophoflavescenol: PDE5 inhibitor (K(i) 0.005 µM), antioxidant, anti-inflammatory, pro-apoptotic, potential antitumor, mild side effects.</p>Formula:C21H20O6Purity:99.65%Color and Shape:SolidMolecular weight:368.38LX2343
CAS:<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Formula:C22H19ClN2O6SPurity:99.45%Color and Shape:SolidMolecular weight:474.91AZD3839 free base
CAS:<p>AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.</p>Formula:C24H16F3N5Purity:99.93% - 99.96%Color and Shape:SolidMolecular weight:431.41Epiberberine
CAS:<p>1.</p>Formula:C20H18NO4Purity:98.52% - 99.59%Color and Shape:SolidMolecular weight:336.36LY2886721
CAS:<p>LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.</p>Formula:C18H16F2N4O2SPurity:99% - 99.75%Color and Shape:SolidMolecular weight:390.41Aloenin
CAS:<p>1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.</p>Formula:C19H22O10Purity:99.42% - 99.69%Color and Shape:SolidMolecular weight:410.37Scoulerine
CAS:<p>Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1).</p>Formula:C19H21NO4Purity:98.62%Color and Shape:SolidMolecular weight:327.37Eslicarbazepine Acetate
CAS:<p>Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.</p>Formula:C17H16N2O3Purity:99.58% - >99.99%Color and Shape:White To Off-White SolidMolecular weight:296.32Aloeresin D
CAS:<p>Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).</p>Formula:C29H32O11Purity:98.11% - 99.57%Color and Shape:SolidMolecular weight:556.56Umibecestat HCl
CAS:<p>Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.</p>Formula:C19H16Cl2F7N5O2Purity:99.92%Color and Shape:SolidMolecular weight:550.26Tenuifolin
CAS:<p>Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.</p>Formula:C36H56O12Purity:97.37% - 99.54%Color and Shape:SolidMolecular weight:680.82Epiberberine chloride
CAS:<p>Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.</p>Formula:C20H18ClNO4Purity:99.89%Color and Shape:SolidMolecular weight:371.81Lanabecestat
CAS:<p>Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.</p>Formula:C26H28N4OPurity:98.55%Color and Shape:SolidMolecular weight:412.53BACE1-IN-1
CAS:<p>BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).</p>Formula:C18H14F3N5O2Purity:98%Color and Shape:SolidMolecular weight:389.33Atabecestat
CAS:<p>Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.</p>Formula:C18H14FN5OSPurity:99.21% - 99.77%Color and Shape:SolidMolecular weight:367.4BACE1-IN-2
CAS:<p>BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).</p>Formula:C19H15F4N5O2Purity:98%Color and Shape:SolidMolecular weight:421.35AM-6494
CAS:<p>AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).</p>Formula:C22H21F2N5O3SPurity:98%Color and Shape:SolidMolecular weight:473.5PF-06751979
CAS:<p>PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).</p>Formula:C18H19F2N5O3S2Purity:98%Color and Shape:SolidMolecular weight:455.5BACE1-IN-5
CAS:<p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.</p>Formula:C18H16F5N5O2SPurity:98%Color and Shape:SolidMolecular weight:461.41BACE1-IN-4
CAS:<p>BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.</p>Formula:C21H23F2N5O4S2Purity:98%Color and Shape:SolidMolecular weight:511.57Umibecestat
CAS:<p>Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.</p>Formula:C19H15ClF7N5O2Purity:99.88%Color and Shape:SolidMolecular weight:513.8NB-360
CAS:<p>NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.</p>Formula:C21H19F4N5O2Purity:99.72%Color and Shape:SolidMolecular weight:449.4
