BACE
BACE inhibitors are compounds that target the Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), which is crucial for the production of beta-amyloid, a protein associated with the formation of amyloid plaques in Alzheimer's disease. By inhibiting BACE, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, potentially slowing the progression of Alzheimer's disease. BACE inhibitors are a major focus in the development of therapeutic strategies for neurodegenerative diseases. At CymitQuimica, we offer BACE inhibitors to support your research in Alzheimer's disease, amyloid biology, and neurodegeneration.
Found 35 products for "BACE".
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Sophoflavescenol
CAS:Sophoflavescenol: PDE5 inhibitor (K(i) 0.005 µM), antioxidant, anti-inflammatory, pro-apoptotic, potential antitumor, mild side effects.Formula:C21H20O6Purity:99.65%Color and Shape:SolidMolecular weight:368.3799LX2343
CAS:LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.Formula:C22H19ClN2O6SPurity:99.45%Color and Shape:SolidMolecular weight:474.914Umibecestat HCl
CAS:Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.Formula:C19H16Cl2F7N5O2Purity:99.92%Color and Shape:White SolidMolecular weight:550.26Epiberberine chloride
CAS:Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.Formula:C20H18ClNO4Purity:99.97%Color and Shape:Orange SolidMolecular weight:371.814DSS30
CAS:DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.Formula:C16H14ClNO3S2Purity:99.19% - 99.4%Color and Shape:SolidMolecular weight:367.87BACE1-IN-1
CAS:BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Formula:C18H14F3N5O2Purity:98%Color and Shape:SolidMolecular weight:389.3313Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Formula:C26H28N4OPurity:98.55%Color and Shape:SolidMolecular weight:412.5267Atabecestat
CAS:Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Formula:C18H14FN5OSPurity:99.27% - 99.87%Color and Shape:SolidMolecular weight:367.4BACE1-IN-5
CAS:BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.Formula:C18H16F5N5O2SPurity:98%Color and Shape:SolidMolecular weight:461.41AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Formula:C22H21F2N5O3SPurity:98%Color and Shape:SolidMolecular weight:473.5PF-06751979
CAS:PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Formula:C18H19F2N5O3S2Purity:98%Color and Shape:SolidMolecular weight:455.502BACE1-IN-2
CAS:BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Formula:C19H15F4N5O2Purity:98%Color and Shape:SolidMolecular weight:421.35Umibecestat
CAS:Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.Formula:C19H15ClF7N5O2Purity:99.88%Color and Shape:SolidMolecular weight:513.797NB-360
CAS:NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.Formula:C21H19F4N5O2Purity:99.72%Color and Shape:SolidMolecular weight:449.4015AZD3839 free base
CAS:AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.Formula:C24H16F3N5Purity:99.93% - 99.96%Color and Shape:White SolidMolecular weight:431.4125
