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BACE

BACE

BACE inhibitors are compounds that target the Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), which is crucial for the production of beta-amyloid, a protein associated with the formation of amyloid plaques in Alzheimer's disease. By inhibiting BACE, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, potentially slowing the progression of Alzheimer's disease. BACE inhibitors are a major focus in the development of therapeutic strategies for neurodegenerative diseases. At CymitQuimica, we offer BACE inhibitors to support your research in Alzheimer's disease, amyloid biology, and neurodegeneration.

Found 36 products of "BACE"

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  • Scoulerine
    Targetmol
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    Scoulerine

    CAS:
    <p>Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1).</p>
    Formula:C19H21NO4
    Purity:98.62%
    Color and Shape:Solid
    Molecular weight:327.37

    Ref: TM-TN2190

  • Eslicarbazepine Acetate
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    Eslicarbazepine Acetate

    CAS:
    <p>Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.</p>
    Formula:C17H16N2O3
    Purity:99.58% - >99.99%
    Color and Shape:White To Off-White Solid
    Molecular weight:296.32

    Ref: TM-T3285

  • Aloeresin D
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    Aloeresin D

    CAS:
    <p>Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).</p>
    Formula:C29H32O11
    Purity:98.11% - 99.57%
    Color and Shape:Solid
    Molecular weight:556.56

    Ref: TM-T8179

  • Umibecestat HCl
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    Umibecestat HCl

    CAS:
    <p>Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.</p>
    Formula:C19H16Cl2F7N5O2
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:550.26

    Ref: TM-T69664

  • Tenuifolin
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    Tenuifolin

    CAS:
    <p>Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.</p>
    Formula:C36H56O12
    Purity:97.37% - 99.54%
    Color and Shape:Solid
    Molecular weight:680.82

    Ref: TM-T3769

  • Epiberberine chloride
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    Epiberberine chloride

    CAS:
    <p>Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.</p>
    Formula:C20H18ClNO4
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:371.81

    Ref: TM-T8306

  • Lanabecestat
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    Lanabecestat

    CAS:
    <p>Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.</p>
    Formula:C26H28N4O
    Purity:98.55%
    Color and Shape:Solid
    Molecular weight:412.53

    Ref: TM-TQ0238

  • BACE1-IN-1
    Targetmol
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    BACE1-IN-1

    CAS:
    <p>BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).</p>
    Formula:C18H14F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.33

    Ref: TM-T10450

  • Atabecestat
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    Atabecestat

    CAS:
    <p>Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.</p>
    Formula:C18H14FN5OS
    Purity:99.21% - 99.77%
    Color and Shape:Solid
    Molecular weight:367.4

    Ref: TM-T14338

  • BACE1-IN-2
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    BACE1-IN-2

    CAS:
    <p>BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).</p>
    Formula:C19H15F4N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:421.35

    Ref: TM-T10451

  • AM-6494
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    AM-6494

    CAS:
    <p>AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).</p>
    Formula:C22H21F2N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:473.5

    Ref: TM-T10292

  • PF-06751979
    Targetmol
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    PF-06751979

    CAS:
    <p>PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).</p>
    Formula:C18H19F2N5O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:455.5

    Ref: TM-T12429

  • BACE1-IN-5
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    BACE1-IN-5

    CAS:
    <p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) &amp; Aβ production (IC50: 0.82 nM), enhances hERG inhibition &amp; P-gp efflux.</p>
    Formula:C18H16F5N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:461.41

    Ref: TM-T10453

  • BACE1-IN-4
    Targetmol
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    BACE1-IN-4

    CAS:
    <p>BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.</p>
    Formula:C21H23F2N5O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:511.57

    Ref: TM-T10452

  • Umibecestat
    Targetmol
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    Umibecestat

    CAS:
    <p>Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM &amp; 10 nM), potentially for Alzheimer's research.</p>
    Formula:C19H15ClF7N5O2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:513.8

    Ref: TM-T13253

  • NB-360
    Targetmol
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    NB-360

    CAS:
    <p>NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.</p>
    Formula:C21H19F4N5O2
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:449.4

    Ref: TM-T12188