AChR
Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.
Found 574 products of "AChR"
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Pozanicline hydrochloride
<p>Pozanicline hydrochloride is an oral α4β2 nAChR agonist with a 16.7 nM Ki, insignificantly binding to α7 nAChR.</p>Formula:C11H17ClN2OPurity:97.13% - 99.81%Color and Shape:SolidMolecular weight:228.72AC1-IN-1
CAS:<p>AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).</p>Formula:C18H18FN5O2Purity:99.89%Color and Shape:SolidMolecular weight:355.37Perlapine
CAS:<p>Perlapine is an effective and selective HM3DQ DREADD agonist (EC50 = 2.8 nM).</p>Formula:C19H21N3Color and Shape:SolidMolecular weight:291.39M3/PDE4 modulator-1
<p>M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.</p>Formula:C38H41Cl2N3O8SColor and Shape:SolidMolecular weight:770.72α-Conotoxin PIA TFA
<p>α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist.</p>Formula:C81H126F3N27O27S4Purity:98.81%Color and Shape:SolidMolecular weight:2095.3nAChR agonist CMPI hydrochloride
CAS:<p>CMPI hydrochloride: Potent α4:α4 nAChR PAM; EC50 0.26 μM for (α4)3(β2)2 response to ACh; may aid nicotine dependence, neuropsychiatric research.</p>Formula:C18H20Cl2N4OColor and Shape:SolidMolecular weight:379.29M 8218
CAS:<p>M 8218 is a bioactive chemical.</p>Formula:C20H29NO2Color and Shape:SolidMolecular weight:315.45Mant-GTPγS
CAS:<p>Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.</p>Formula:C18H23N6O14P3SColor and Shape:SolidMolecular weight:672.39Muscarinic toxin 3
CAS:<p>Muscarinic toxin 3 (MT3), a potent non-competitive antagonist of mAChR and adrenoceptors, exhibits pIC50 values of 6.71 for M1, 8.79 for M4, 8.86 for α1A, 7.57</p>Formula:C319H489N89O97S8Purity:98%Color and Shape:SolidMolecular weight:7379.35Navafenterol
CAS:<p>AZD-8871, a potential COPD and asthma treatment, may work well with ICS.</p>Formula:C38H42N6O6S2Color and Shape:SolidMolecular weight:742.91Anabaseine
CAS:<p>Anabaseine is a broad nicotinic agonist, favoring alpha-7 AChRs in muscle/brain, and weakly stimulates alpha-4 beta-2 nAChRs.</p>Formula:C10H12N2Color and Shape:SolidMolecular weight:160.22BTMPS
CAS:<p>BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use.</p>Formula:C28H52N2O4Purity:98.1%Color and Shape:SolidMolecular weight:480.72Biperiden Hydrochloride
CAS:<p>Biperiden HCl is an anti-Parkinson's drug, blocks M1 receptors, manages all Parkinson's types, and is FDA-approved. Non-toxic at 0.11 mg/kg to rats' cognition.</p>Formula:C21H30ClNOPurity:98%Color and Shape:SolidMolecular weight:347.92Anagyrine hydrochloride
CAS:<p>Anagyrine hydrochloride, a quinolizidine from Lupinus albus, targets muscarinic/nicotinic receptors; IC50: 132/2096 µM. It desensitizes nAChR directly.</p>Formula:C15H21ClN2OColor and Shape:SolidMolecular weight:280.79DSPE-PEG1000-RVG29
<p>DSPE-PEG1000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 can specifically bind to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and cross the BBB.</p>Color and Shape:Odour SolidEmraclidine
CAS:<p>Emraclidine (CVL-231) is a novel, highly selective allosteric modulator of the muscarinic M4 receptor positive receptor.Cost-effective and quality-assured.</p>Formula:C20H21F3N4OPurity:99.96%Color and Shape:SolidMolecular weight:390.4TIP 39, Tuberoinfundibular Neuropeptide
CAS:<p>TIP39 is a synthetic neuropeptide agonist for human and rat PTH2 receptors from the hypothalamus.</p>Formula:C202H325N61O54SPurity:98%Color and Shape:SolidMolecular weight:4504.2Destomycin A
CAS:<p>Destomycin A, an aminoglycoside antibiotic, exhibits activity against bacterial (Gram-positive and Gram-negative), antifungal, and anthelmintic agents. It inhibits peptide synthesis in Escherichia coli cells and stimulates adenylate cyclase in animal tissues.</p>Formula:C20H37N3O13Color and Shape:SolidMolecular weight:527.52PDE4-IN-4
CAS:<p>PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of</p>Formula:C36H37Cl2N3O7SColor and Shape:SolidMolecular weight:726.67MK-0969
CAS:<p>MK-0969 (J-104135) is a possible M3 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Formula:C24H30F2N4O2Color and Shape:SolidMolecular weight:444.52Fentonium bromide
CAS:<p>Fentonium bromide is a biochemical.</p>Formula:C31H34BrNO4Color and Shape:SolidMolecular weight:564.51[D-Trp7,9,10]-Substance P
CAS:<p>Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.</p>Formula:C79H105N21O13SPurity:98%Color and Shape:SolidMolecular weight:1588.89Small Cardioactive Peptide B (SCPB)
CAS:<p>SCPB: neurally active peptide, boosts adenylate cyclase in heart/gills, EC50s: 0.1 μM (heart), 1.0 μM (gills).</p>Formula:C52H80N14O11S2Purity:98%Color and Shape:SolidMolecular weight:1141.41TDI-10229
CAS:<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Formula:C16H16ClN5Purity:99.85% - 99.89%Color and Shape:SoildMolecular weight:313.78DSPE-PEG5000-RVG29
<p>DSPE-PEG5000-RVG29 is a PEG compound comprised of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and facilitates passage through the BBB.</p>Color and Shape:Odour SolidAceclidine (hydrochloride)
CAS:<p>agonist of muscarinic receptors</p>Formula:C9H16ClNO2Purity:98%Color and Shape:SolidMolecular weight:205.68Ebiratide
CAS:<p>Ebiratide is an analog of ACTH 4-9.</p>Formula:C48H73N11O10SPurity:98%Color and Shape:SolidMolecular weight:996.23R-(+)-Cotinine
CAS:<p>R-(+)-Cotinine, an inactive nicotine metabolite, boosts Ach-induced current in human α7 nAChRs.</p>Formula:C10H12N2OColor and Shape:SolidMolecular weight:176.22VU6028418
CAS:<p>VU6028418 is a highly selective, potent, orally active M4mAChR antagonist that acts on hM4 (IC50: 4.1 nM).</p>Color and Shape:SolidThiothixene
CAS:<p>Thiothixene has a wide range of applications in life science related research.</p>Formula:C23H29N3O2S2Color and Shape:SolidMolecular weight:443.62Epiboxidine hydrochloride
CAS:<p>Epiboxidine HCl: potent α4β2 nAChR agonist; Ki 0.46 nM (rat), 1.2 nM (human); Epibatidine analog.</p>Formula:C10H15ClN2OColor and Shape:SolidMolecular weight:214.69Dicloromezotiaz
CAS:<p>Dicloromezotiaz: Potent insecticide targeting nAChRs, controls various lepidoptera.</p>Formula:C19H12Cl3N3O2SColor and Shape:SolidMolecular weight:452.74Proadrenomedullin (1-20), human
CAS:<p>Endogenous peptide; agonist of MRGPRX2 (EC50=251 nM); noncompetitive inhibitor of nicotinic receptors; reduces catecholamine secretion; antihypertensive.</p>Formula:C112H178N36O27Purity:98%Color and Shape:SolidMolecular weight:2460.84(+)-Coclaurine hydrochloride
CAS:<p>(+)-Coclaurine hydrochloride, also known as (+)-(R)-Coclaurine, is a benzyltetrahydroisoquinoline alkaloid extracted from multiple plant species.</p>Formula:C17H20ClNO3Purity:98%Color and Shape:SolidMolecular weight:321.8LtIA-F
<p>LtIA-F, a fluorescent LtIA derivative, aids study of α3β2 nAChR's structure, distribution, and binding domain.</p>Formula:C86H121N25O22S4Color and Shape:SolidMolecular weight:1985.31(S)-Dinotefuran
CAS:<p>(S)-Dinotefuran, a neonicotinoid, more toxic to bees than its R-isomer, targets α8 nAChR.</p>Formula:C7H14N4O3Color and Shape:SolidMolecular weight:202.21nAChR agonist 2
CAS:<p>Compound 8, identified as a selective alpha4beta2 (α4β2) neuronal acetylcholine receptor (nAChR) agonist, demonstrates a dissociation constant (Kd) of 26 nM,</p>Formula:C11H16N2Color and Shape:SolidMolecular weight:176.263M4 mAChR agonist-1
CAS:<p>M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).</p>Formula:C14H18N4OSPurity:99.14%Color and Shape:SolidMolecular weight:290.38ANQ-9040
CAS:<p>ANQ-9040 is a nondepolarizing neuromuscular relaxant of the steroid class.</p>Formula:C36H58N2O5SColor and Shape:SolidMolecular weight:630.92Oxotremorine
CAS:<p>Oxotremorine acts as an agonist of mAChR, specifically activating the M1 and M3 acetylcholine receptors. In drug discrimination experiments with macaques, it exhibits effects similar to nicotine.</p>Formula:C12H18N2OColor and Shape:SolidMolecular weight:206.28Br-PBTC
CAS:<p>Br-PBTC modulates nAChRs; targets α2/β2,4 subtypes; potent with 0.1-0.6 μM EC50; binds α subunit c-tail.</p>Formula:C14H15BrN2OSColor and Shape:SolidMolecular weight:339.25Guanylyl Imidodiphosphate (lithium salt)
CAS:<p>Guanylyl Imidodiphosphate (lithium salt) is a non-hydrolyzable GTP analog that increases adenylate cyclase activity.</p>Formula:C10H13Li4N6O13P3Color and Shape:SolidMolecular weight:545.93nAChR modulator-2
CAS:<p>nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>Formula:C12H8ClN3O2Color and Shape:SolidMolecular weight:261.66Irsogladine maleate
CAS:<p>Compound PDK0375, with CAS No. 84504-69-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0375 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formula:C9H7Cl2N5Color and Shape:SolidMolecular weight:256.09trans-Cevimeline hydrochloride
CAS:<p>AF 102A hydrochloride is a biochemical.</p>Formula:C10H18ClNOSColor and Shape:SolidMolecular weight:235.77Albanin A
<p>Albanin A is a useful organic compound for research related to life sciences and the catalog number is T124310.</p>Formula:C20H18O6Color and Shape:SolidMolecular weight:354.358Hydroxybupropion
CAS:<p>Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).</p>Formula:C13H18ClNO2Purity:99.73%Color and Shape:Off-White SolidMolecular weight:255.74nAChR modulator-1
CAS:<p>nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>Formula:C12H8ClN3O2Color and Shape:SolidMolecular weight:261.66bPiDDB
CAS:<p>bPiDDB (N,N'-Dodecylbis-Picolinium Bromide) is a nicotinic receptor (nAChR) antagonist.</p>Formula:C24H38Br2N2Purity:98.72%Color and Shape:SolidMolecular weight:514.38Octamylamine
CAS:<p>Octamylamine is a bioactive chemical.</p>Formula:C13H29NColor and Shape:SolidMolecular weight:199.3761
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