AChR
Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.
Found 574 products of "AChR"
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M4 mAChR agonist-1
CAS:<p>M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).</p>Formula:C14H18N4OSPurity:99.14%Color and Shape:SolidMolecular weight:290.38Muscarine
CAS:<p>Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.</p>Formula:C9H20NO2Purity:98%Color and Shape:SolidMolecular weight:174.26M3/PDE4 modulator-1
<p>M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.</p>Formula:C38H41Cl2N3O8SColor and Shape:SolidMolecular weight:770.725-AMAM-2-CP
CAS:<p>5-AMAM-2-CP, a significant metabolite of Acetamiprid, serves as a global insecticide within the neonicotinoid class and acts as an nAChR agonist [1] [2].</p>Formula:C9H11ClN2OColor and Shape:SolidMolecular weight:198.65(R)-Dinotefuran
CAS:<p>(R)-Dinotefuran, a neonicotinoid, is 1.7-2.4x more effective against pests like Aphis gossypii and safer for bees.</p>Formula:C7H14N4O3Color and Shape:SolidMolecular weight:202.21Ebiratide TFA
<p>Ebiratide (HOE-427) TFA is a derivative of ACTH4-9 that exerts its effect directly on the central nervous system, enhancing memory. Ebiratide TFA also promotes the metabolism of acetylcholine (ACh) in the rat brain.</p>Formula:C48H73N11O10S·xC2HF3O2Color and Shape:SolidMolecular weight:996.23 (free base)TDI-10229
CAS:<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Formula:C16H16ClN5Purity:99.85% - 99.89%Color and Shape:SoildMolecular weight:313.78BTMPS
CAS:<p>BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use.</p>Formula:C28H52N2O4Purity:98.1%Color and Shape:SolidMolecular weight:480.72Anabaseine
CAS:<p>Anabaseine is a broad nicotinic agonist, favoring alpha-7 AChRs in muscle/brain, and weakly stimulates alpha-4 beta-2 nAChRs.</p>Formula:C10H12N2Color and Shape:SolidMolecular weight:160.22N-Ethyl-N-(3-pyridylmethyl)amine
CAS:<p>N-Ethyl-N-(3-pyridylmethyl)amine has affinity for nAChR (Ki = 0.97 µM) and can be used in related research in the field of life sciences.</p>Formula:C8H12N2Purity:99.65%Color and Shape:SolidMolecular weight:136.19Soclenicant
CAS:<p>Soclenicant is a negative-altering modulator of α 7 -nAChR for anxiety, depression, and PTSD, due to its high selectivity, oral availability</p>Formula:C24H26N4O3Purity:99.57%Color and Shape:SoildMolecular weight:418.49Rivanicline 2HCl
<p>Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.</p>Formula:C10H16Cl2N2Purity:99.4%Color and Shape:SoildMolecular weight:235.15Proadrenomedullin (1-20), human
CAS:<p>Endogenous peptide; agonist of MRGPRX2 (EC50=251 nM); noncompetitive inhibitor of nicotinic receptors; reduces catecholamine secretion; antihypertensive.</p>Formula:C112H178N36O27Purity:98%Color and Shape:SolidMolecular weight:2460.84TC-2559 difumarate
CAS:<p>TC-2559 difumarate: Oral α4β2 nAChR partial agonist, CNS-selective, EC50 0.18 μM, prefers α4β2 over α2β4/α4β4/α3β4, antinociceptive.</p>Formula:C20H26N2O9Color and Shape:SolidMolecular weight:438.43Bensultap
CAS:<p>Bensultap is an agricultural chemical typically used as a pesticide.</p>Formula:C17H21NO4S4Purity:98%Color and Shape:SolidMolecular weight:431.61Ebiratide
CAS:<p>Ebiratide is an analog of ACTH 4-9.</p>Formula:C48H73N11O10SPurity:98%Color and Shape:SolidMolecular weight:996.23GeX-2
CAS:<p>GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.</p>Formula:C103H169N43O27Color and Shape:SolidMolecular weight:2441.72Aceclidine (hydrochloride)
CAS:<p>agonist of muscarinic receptors</p>Formula:C9H16ClNO2Purity:98%Color and Shape:SolidMolecular weight:205.68Tropicamide
CAS:<p>Tropicamide (Ro 1-7683), a synthetic atropine-like muscarinic antagonist, dilates pupils and paralyzes eye muscles for diagnostic use.</p>Formula:C17H20N2O2Purity:99.78% - 99.94%Color and Shape:White PowderMolecular weight:284.35Navafenterol
CAS:<p>AZD-8871, a potential COPD and asthma treatment, may work well with ICS.</p>Formula:C38H42N6O6S2Color and Shape:SolidMolecular weight:742.91α-Conotoxin PIA
CAS:<p>Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM</p>Formula:C79H125N27O25S4Purity:98%Color and Shape:SolidMolecular weight:1981.3(-)-OPC-51803
CAS:<p>(-)-OPC-51803 is an antidiuretic hormone V2 receptor agonist used in the treatment of nocturia and urinary incontinence.</p>Formula:C26H32ClN3O2Purity:98.73% - 99.59%Color and Shape:SoildMolecular weight:454(rel)-Asperparaline A
CAS:<p>Aspergillimide, from A. japonicus, inhibits silkworm neuron nAChRs (IC50s: 20.2/39.6 nM), not affecting chicken nAChRs, and paralyzes silkworm larvae.</p>Formula:C20H29N3O3Color and Shape:SolidMolecular weight:359.47sabcomeline
CAS:<p>Sabcomeline: potent, selective M1 agonist; boosts cognition; for Alzheimer's study.</p>Formula:C10H15N3OColor and Shape:SolidMolecular weight:193.25DSPE-PEG2000-RVG29
<p>DSPE-PEG2000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and can traverse the BBB.</p>Color and Shape:Odour SolidLu AE51090
CAS:<p>Lu AE51090 is a selective muscarinic M1 receptor agonist with minimal off-target effects, receptor function and selective pharmacological modulation.</p>Formula:C24H29N3O3Purity:99.57%Color and Shape:SolidMolecular weight:407.515-AAM-2-CP
CAS:<p>5-AAM-2-CP is one of the major metabolites of Acetamiprid. Acetamiprid, a nAChR agonist, is a neonicotinoid insecticide used worldwide.</p>Formula:C8H9ClN2OPurity:99.58%Color and Shape:SolidMolecular weight:184.62(R)-(+)-Anatabine
CAS:<p>(R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent agonist of α4β2 nAChR.</p>Formula:C10H12N2Purity:98%Color and Shape:SolidMolecular weight:160.22(Rac)-Sabcomeline
CAS:<p>(Rac)-Sabcomeline ((Rac)-SB-202026) is an M1/M4 muscarinic agonist used in the study of neurologic disorders such as schizophrenia.</p>Formula:C10H15N3OPurity:99.14%Color and Shape:SolidMolecular weight:193.25LAS190792
CAS:<p>LAS190792 (AZD8999) is a dual muscarinic antagonist/β2-agonist, pIC50s (M1-M5, β1-β3): 8.9-5.6; used as a bronchodilator.</p>Formula:C39H43ClN4O9S2Color and Shape:SolidMolecular weight:811.36Br-PBTC
CAS:<p>Br-PBTC modulates nAChRs; targets α2/β2,4 subtypes; potent with 0.1-0.6 μM EC50; binds α subunit c-tail.</p>Formula:C14H15BrN2OSColor and Shape:SolidMolecular weight:339.25β2AR/M-receptor agonist-1
CAS:<p>β2AR/M-receptor agonist-1 (example 131), a muscarinic antagonist and β2 adrenoceptor agonist (MABA), exhibits dual potency towards β2 adrenoceptor and</p>Formula:C43H56BrN3O7Color and Shape:SolidMolecular weight:806.82Dexetimide
CAS:<p>Dexetimide, a muscarinic receptor antagonist, treats neuroleptic-induced parkinsonism.</p>Formula:C23H26N2O2Color and Shape:SolidMolecular weight:362.46Metixene hydrochloride hydrate
CAS:<p>Metixene HCl hydrate is a potential anticholinergic for Parkinson's with IC50 of 55 nM and Ki of 15 nM against muscarine receptors.</p>Formula:C20H26ClNOSPurity:99.88%Color and Shape:SolidMolecular weight:363.95Fipexide hydrochloride
CAS:<p>Fipexide (hydrochloride) is a kind of psychoactive drug of the piperazine class.</p>Formula:C20H22Cl2N2O4Color and Shape:SolidMolecular weight:425.31NKH477
CAS:<p>NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity.</p>Formula:C27H44ClNO8Purity:98% - 98%Color and Shape:SolidMolecular weight:546.09Tolterodine
CAS:<p>Tolterodine ((R)-(+)-Tolterodine) is an mACh antagonist used in the treatment of detrusor instability and overactive bladder syndrome.</p>Formula:C22H31NOPurity:99.71%Color and Shape:White Like Or Light Brown Crystalline PowderMolecular weight:325.49YM-58790 hydrochloride
CAS:<p>YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).</p>Formula:C27H32ClN3O2Purity:98%Color and Shape:SolidMolecular weight:466.02Palmatine hydroxide
CAS:<p>Palmatine hydroxide: oral IDO-1 inhibitor (IC50: 3-157μM), targets WNV protease, has anti-cancer/viral and neuroprotective properties.</p>Formula:C21H23NO5Color and Shape:SolidMolecular weight:369.41Cevimeline
CAS:<p>Cevimeline: muscarinic agonist, treats dry mouth & Sjögren's, boosts saliva post-cancer radiotherapy.</p>Formula:C10H17NOSColor and Shape:Off-White SolidMolecular weight:199.31Pirmenol hydrochloride
CAS:<p>Pirmenol hydrochloride functions by inhibiting I_K.ACh through the blockade of muscarinic receptors, demonstrating a potent effect with an IC_50 value of 0.1 μM</p>Formula:C22H31ClN2OColor and Shape:SolidMolecular weight:374.95Varenicline Hydrochloride
CAS:<p>Varenicline Hydrochloride (CP 526555) is an orally active partial agonist of the α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50 = 250 nM).</p>Formula:C13H14ClN3Purity:99.854%Color and Shape:SolidMolecular weight:247.72Cevimeline hydrochloride
CAS:<p>Cevimeline HCl is a muscarinic agonist enhancing salivary and sweat gland secretion.</p>Formula:C10H18ClOSColor and Shape:SolidMolecular weight:235.77Glycerophosphoinositol choline
CAS:<p>Glycerophosphoinositol choline is the salt of choline and glycerophosphoinositol.</p>Formula:C14H32NO12PColor and Shape:SolidMolecular weight:437.38Ispronicline
CAS:<p>Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive</p>Formula:C14H22N2OPurity:97.70% - 99.16%Color and Shape:SolidMolecular weight:234.34Sabcomeline hydrochloride
CAS:<p>Sabcomeline is a selective M1 receptor partial agonist.</p>Formula:C10H16ClN3OColor and Shape:SolidMolecular weight:229.71(±)-Darifenacin
CAS:<p>(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective antagonist of M3 muscarinic receptor.</p>Formula:C28H30N2O2Color and Shape:SolidMolecular weight:426.55VU0467485
CAS:<p>VU0467485 boosts ACh at M4 receptors (EC50: 26.6 nM rat, 78.8 nM human), selective for M4 over M1/2/3/5.</p>Formula:C17H17FN4O2SPurity:98%Color and Shape:SolidMolecular weight:360.41Clorprenaline
CAS:<p>Clorprenaline is a β-adrenergic receptor agonist that activates adenylate cyclase, relaxation of bronchial smooth muscle cells. anti-inflammatory.</p>Formula:C11H16ClNOPurity:98.9%Color and Shape:SolidMolecular weight:213.7ABT-107
CAS:<p>ABT-107: α7 neuronal receptor agonist; protects rats' brains from 6-OHDA-induced damage.</p>Formula:C19H20N4OColor and Shape:SolidMolecular weight:320.396
