AChR
Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.
Found 643 products of "AChR"
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Encenicline
CAS:Encenicline (EVP-6124), a selective α7 nAChRs agonist, targets cognitive impairment in schizophrenia and Alzheimer's.Formula:C16H17ClN2OSPurity:99.20%Color and Shape:SolidMolecular weight:320.84Ref: TM-T7193
1mg70.00€5mg133.00€10mg207.00€25mg349.00€50mg495.00€100mg675.00€200mg888.00€1mL*10mM (DMSO)144.00€GNF-7
CAS:GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.Formula:C28H24F3N7O2Purity:97.05% - 99.7%Color and Shape:SolidMolecular weight:547.53Fmoc-Val-Ala-PAB-OH
CAS:Fmoc-Val-Ala-PAB-OH is a linker for ADCs and lysosomally cleavable RGD-paclitaxel conjugates.Formula:C30H33N3O5Purity:98.45% - 98.94%Color and Shape:SolidMolecular weight:515.6α-Conotoxin PIA acetate
α-Conotoxin PIA acetate is an antagonist of nicotinic acetylcholine receptor (nAChR) mainly targeting α6 and α3 subunits.Purity:98%Color and Shape:LiquidMolecular weight:N/AIsopropamide Iodide
CAS:Isopropamide iodide: long-acting anticholinergic, treats peptic ulcers, GI disorders, Alzheimer's.
Formula:C23H33IN2OPurity:99.67%Color and Shape:SolidMolecular weight:480.43ML380
CAS:ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).Formula:C23H25F3N4O3SPurity:99.69%Color and Shape:SolidMolecular weight:494.53Ref: TM-T28069
2mg47.00€5mg71.00€10mg113.00€25mg178.00€50mg334.00€100mg500.00€500mg1,099.00€1mL*10mM (DMSO)78.00€Irsogladine
CAS:Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.Formula:C9H7Cl2N5Purity:99.74% - 99.91%Color and Shape:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterMolecular weight:256.09VU0152100
CAS:VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).Formula:C18H19N3O2SPurity:99.56%Color and Shape:SolidMolecular weight:341.43Ref: TM-T17238
2mg39.00€5mg58.00€10mg92.00€25mg195.00€50mg325.00€100mg522.00€200mg743.00€1mL*10mM (DMSO)64.00€VU0119498
CAS:VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.Formula:C15H10BrNO2Purity:97.56%Color and Shape:SolidMolecular weight:316.15VU10010
CAS:VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.
Formula:C17H16ClN3OSPurity:99.36%Color and Shape:SolidMolecular weight:345.85Brompheniramine
CAS:Brompheniramine, an alkylamine antihistamine, targets H1 receptors (Kd=6.06nM) and has anticholinergic/depressant qualities. Blocks Ca/Na/hERG channels.Formula:C16H19BrN2Color and Shape:SolidMolecular weight:319.24α-Conotoxin MII acetate
α-Conotoxin MII acetate is a 16-amino acid peptide from the venom of the marine snail Conus magus.Formula:C69H107N23O24S4Purity:94.82% - 97.79%Color and Shape:SolidMolecular weight:1770.99Syn-Ake acetate
CAS:Syn-Ake acetate (Dipeptide diaminobutyroyl benzylamide) is a muscarinic acetylcholine receptor antagonist.Formula:C19H29N5O3·2(C2H4O2)Purity:99.60%Color and Shape:SolidMolecular weight:495.58Oxotremorine sesquifumarate
CAS:Oxotremorine sesquifumarate is a muscarinic agonist.
Formula:C12H18N2OC4H4O4Purity:97.94%Color and Shape:SolidMolecular weight:380.39TQS
CAS:TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors.Formula:C22H20N2O2SPurity:98.56%Color and Shape:SolidMolecular weight:376.47Ref: TM-T23469
5mg35.00€10mg52.00€25mg103.00€50mg167.00€100mg236.00€200mg338.00€1mL*10mM (DMSO)38.00€Tosedostat
CAS:Tosedostat (CHR-2797), an oral M1 aminopeptidase inhibitor, turns into CHR-79888, blocks tumor cell proteins, causing cell death.Formula:C21H30N2O6Purity:98.14% - 99.84%Color and Shape:SolidMolecular weight:406.47Clothianidin
CAS:Clothianidin (TI 435), an insecticide, stimulates nAChR as acetylcholine agonist, not AChE inhibitor.Formula:C6H8ClN5O2SPurity:99.71% - 99.87%Color and Shape:Solid PowderMolecular weight:249.68Propiverine hydrochloride
CAS:Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).Formula:C23H30ClNO3Purity:99.93%Color and Shape:White Crystalling PowerMolecular weight:403.94PHA 568487
CAS:PHA 568487: α-7 nAChR agonist, rapid brain uptake, lessens oxidative stress & neuroinflammation.Formula:C20H24N2O7Color and Shape:SolidMolecular weight:404.419Mecamylamine hydrochloride
CAS:Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension.Formula:C11H22ClNPurity:99.76% - >99.99%Color and Shape:White SolidMolecular weight:203.75JHU37152
CAS:JHU37152 is a DREADD agonist; Ki: 1.8 nM at hM3Dq, 8.7 nM at hM4Di; EC50: 5 nM (hM3Dq), 0.5 nM (hM4Di) in HEK-293 cell assays.Formula:C19H20ClFN4Purity:99.72%Color and Shape:SolidMolecular weight:358.84Revefenacin
CAS:Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.Formula:C35H43N5O4Purity:98.12%Color and Shape:SolidMolecular weight:597.75Varenicline Tartrate
CAS:Varenicline Tartrate (CP 526555-18) is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist.
Formula:C13H13N3·C4H6O6Purity:98.23% - 98.32%Color and Shape:Tan SolidMolecular weight:361.35Piperidolate
CAS:Piperidolate inhibits intestinal cramp induced by acetylcholineFormula:C21H25NO2Purity:98.45%Color and Shape:SolidMolecular weight:323.43PNU-282987 S enantiomer free base
CAS:PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).Formula:C14H17ClN2OPurity:99.74%Color and Shape:SolidMolecular weight:264.75Ref: TM-T7695
1mg71.00€5mg161.00€10mg219.00€25mg338.00€50mg460.00€100mg623.00€200mg837.00€1mL*10mM (DMSO)180.00€Simufilam dihydrochloride
CAS:Simufilam dihydrochloride is an oral, low-toxic FLNA activator for Alzheimer's research, restoring FLNA structure and function.Formula:C15H23Cl2N3OPurity:98.83%Color and Shape:SolidMolecular weight:332.3Ref: TM-T9172
1mg49.00€5mg95.00€10mg136.00€25mg279.00€50mg360.00€100mg470.00€200mg622.00€1mL*10mM (DMSO)96.00€Glycopyrrolate
CAS:Glycopyrrolate: muscarinic antagonist, antispasmodic for GI issues, reduces salivation with anesthesia.Formula:C19H28BrNO3Purity:99.41% - 99.64%Color and Shape:SolidMolecular weight:398.33Sofpironium bromide
CAS:Sofpironium bromide (BBI4000) belongs to a class of drugs called anticholinergics, which exert their effect by blocking the action of acetylcholine.Formula:C22H32BrNO5Purity:98.85%Color and Shape:SolidMolecular weight:470.4Ref: TM-T28827
1mg74.00€5mg160.00€10mg250.00€25mg452.00€50mg680.00€100mg1,008.00€200mg1,349.00€1mL*10mM (DMSO)165.00€Dinotefuran
CAS:Dinotefuran (MTI-446), a neonicotinoid insecticide, targets pests by blocking their nervous system.Formula:C7H14N4O3Purity:99.89%Color and Shape:White Crystalline PowderMolecular weight:202.21Pempidine
CAS:Pempidine (1,2,2,6,6-Pentamethylpiperidine) is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension.Formula:C10H21NPurity:98.18% - 99.28%Color and Shape:Colorless - Light Yellow Clear LiquidMolecular weight:155.28CCMI
CAS:CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric.Formula:C19H15Cl2N3O2Purity:>99.99%Color and Shape:SolidMolecular weight:388.25Pozanicline dihydrochloride
CAS:Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki = 16.7 nM)Formula:C11H18Cl2N2OPurity:98%Color and Shape:SolidMolecular weight:265.18W-84 dibromide
CAS:W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.Formula:C32H44Br2N4O4Purity:95.56%Color and Shape:SolidMolecular weight:708.52Dronedarone
CAS:Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5SPurity:98.85% - 99.99%Color and Shape:SolidMolecular weight:556.76EB-3D
CAS:EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.Formula:C30H36Br2N4O2Purity:99.48%Color and Shape:SolidMolecular weight:644.4Ref: TM-T7955
1mg87.00€2mg114.00€5mg177.00€10mg260.00€25mg447.00€50mg620.00€100mg875.00€200mg1,161.00€1mL*10mM (DMSO)263.00€Nor-benzetimide
CAS:Norbenzetimide, an organic compound, is prepared from benzetimide by catalytic transfer hydrogenolysis.Formula:C16H20N2O2Purity:98.63%Color and Shape:SolidMolecular weight:272.34Ref: TM-T22380
1mg72.00€5mg136.00€10mg197.00€25mg324.00€50mg452.00€100mg607.00€200mg810.00€1mL*10mM (DMSO)135.00€Pempidine HCl
CAS:Pempidine HCl, a nicotinic antagonist and former hypertension treatment, now mainly serves as a lab tool.Formula:C10H22ClNColor and Shape:SolidMolecular weight:191.74(S)-UFR2709
CAS:(S)-UFR2709, a nAChR competitive antagonist, favors α4β2 over α7, reduces anxiety and alcohol use in rats.Formula:C13H17NO2Color and Shape:SolidMolecular weight:219.284Adiphenine
CAS:Adiphenine is an inhibitor of nicotinic receptors.Formula:C20H25NO2Color and Shape:SolidMolecular weight:311.42Solifenacin
CAS:Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0,Formula:C23H26N2O2Purity:99.87%Color and Shape:SolidMolecular weight:362.46VU0152099
CAS:VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).Formula:C18H17N3O3SPurity:98.46%Color and Shape:SolidMolecular weight:355.41BQCA
CAS:BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator.Formula:C18H15NO4Purity:97.22%Color and Shape:SolidMolecular weight:309.32VU0238441
CAS:VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.Formula:C16H9ClF3NO2Purity:100%Color and Shape:SolidMolecular weight:339.7Batefenterol Succinate
CAS:Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.Formula:C44H48ClN5O11Color and Shape:SolidMolecular weight:858.34Bestim
CAS:Bestim is an immunomodulatory dipeptide that is synthetic.Formula:C16H19N3O5Purity:99.76%Color and Shape:SolidMolecular weight:333.34Ref: TM-T25146
1mg84.00€5mg168.00€10mg245.00€25mg404.00€50mg567.00€100mg767.00€200mg1,018.00€1mL*10mM (DMSO)172.00€9-Ethyladenine
CAS:9-Ethyladenine (6-Amino-9-ethylpurine) is a partially potent APRT (adenine phosphoribosyltransferase) inhibitor [1].Formula:C7H9N5Purity:99.35% - 99.37%Color and Shape:SolidMolecular weight:163.18Oxyphenonium bromide
CAS:Oxyphenonium bromide is an anticholinergic used to study and treat ulcers and relieve visceral spasms.
Formula:C21H34BrNO3Purity:98.96%Color and Shape:SolidMolecular weight:428.404Harman hydrochloride
CAS:Harman hydrochloride triggers CYP1A1 gene via AhR, potentially causing mutations and cancer.Formula:C12H11ClN2Purity:99.35%Color and Shape:SolidMolecular weight:218.68BNC210
CAS:BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.Formula:C17H23N3O3Purity:97.05% - >99.99%Color and Shape:SolidMolecular weight:317.38NS9283
CAS:NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.
Formula:C14H8N4OPurity:99.12%Color and Shape:SolidMolecular weight:248.24
