p97
p97 inhibitors are compounds that inhibit p97, also known as Valosin-Containing Protein (VCP), an ATPase involved in various cellular processes, including protein degradation, cell cycle regulation, and DNA repair. p97 is a key player in the ubiquitin-proteasome system and its inhibition is of interest in cancer research, neurodegenerative diseases, and other disorders where protein homeostasis is disrupted. At CymitQuimica, we offer p97 inhibitors to support your research in proteostasis, neurobiology, and cancer therapy.
Found 15 products for "p97".
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MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formula:C29H29F3N2Color and Shape:SolidMolecular weight:462.5492NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formula:C27H28N4O3S2Purity:99.05% - 99.85%Color and Shape:SolidMolecular weight:520.666DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Formula:C22H20N4Purity:98.01% - ≥95%Color and Shape:SolidMolecular weight:340.421NPD8733
CAS:NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.Formula:C18H15NO4Purity:98.48%Color and Shape:SolidMolecular weight:309.316CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Formula:C24H23N5O2Purity:95.95% - 99.92%Color and Shape:SolidMolecular weight:413.4717ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formula:C23H25ClN4OPurity:99.91% - 99.97%Color and Shape:SolidMolecular weight:408.924ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Formula:C23H24N4OPurity:98%Color and Shape:SolidMolecular weight:372.4629ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Formula:C23H20N6OPurity:99.73% - >99.99%Color and Shape:White SolidMolecular weight:396.44UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C23H16ClN3O3SColor and Shape:SolidMolecular weight:449.91UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formula:C20H15ClN2O5SColor and Shape:SolidMolecular weight:430.86UP158
CAS:UP158 is a VCP small-molecule activator (EC₅₀=2.57 μM) that enhances ATPase activity for protein degradation and neurodegenerative disease studies.Formula:C17H17ClN4O2Color and Shape:SolidMolecular weight:344.795CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Formula:C24H24N6OPurity:97.66%Color and Shape:SolidMolecular weight:412.487UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formula:C30H32F2N6O3SPurity:98%Color and Shape:SolidMolecular weight:594.68VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Formula:C24H23N5O2Color and Shape:SolidMolecular weight:413.47p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Formula:C25H26N6O2Color and Shape:SolidMolecular weight:442.51
